|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endoscopic Retrograde Cholangiopancreatography Gut Perforations: When to Wait! When to Operate!显示文摘 | Morgan Katherine A Fontenot Bennett B Ruddy Jean M Mickey Suzanne Adams David B | 2009 | The American Surgeon2009，，6： | 2 |
| 2 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 3 | The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors 显示文摘 | Ozinsky A Underhill DM Fontenot JD | 2000 | Proc Natl Acad Sci USA2000，97，13： | 2 |
| 4 | Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells显示文摘 | Gavin M A Rudensky A Y | 2003 | Nature Immunology2003，4，4： | 1 |
| 5 | FOXP3 programs the development and function of CD4 + CD25 + regulatory T cells显示文摘 | Fontenot JD Gavin MA Rudensky AY | 2003 | Nat Immunol2003，4，4： | 1 |
| 6 | The Comparative Effects of Sevoflurane Versus Propofol in the Induction and Maintenance of Anesthesia in Adult Patients显示文摘 | Jellish WS Lien CA Fontenot HJ | 1996 | Anesth Analg1996，82，： | 1 |
| 7 | The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors显示文摘 | Ozinsky A Underhill D M Fontenot J D | 2000 | Proc Natl Acad Sci USA2000，97，13： | 1 |
| 8 | FoxP3 programs the development and function of CD4+CD25+ regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 9 | Regulatory T cell lineage specification by the forkhead transcription factor foxp3显示文摘 | Fontenot J D Rasmussen J P Williams L M | 2005 | Immunity2005，22，3： | 1 |
| 10 | A well adapted regulatory contrivance regulatory T cell development and the Forkhead family transcription factor Foxp3 显示文摘 | Fontenot JD Rudensky A | 2005 | Nat Immunol2005，6，： | 1 |
| 11 | γδ T cells: an important source of IL-17显示文摘 | Roark CL Simonian PL Fontenot AP | 2008 | Curr Opin Immunol2008，20，3： | 1 |
| 12 | Foxp3 pro- grams the development and function of CD4 + CD25 + reg- ulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 13 | In vitro absorption of amino acids by the smallintestine of sheep显示文摘 | Phillips W A Webb K E Fontenot J P | 1976 | Journal of Animal Science1976，42，： | 1 |
| 14 | Regulatory T cell lineage specification by the fork head transcription factor foxp3显示文摘 | Fontenot JD Rasmussen JP Williams LM Dooley JL Farr AG Rudensky AY | 2005 | Immunity2005，22，3： | 1 |
| 15 | The reper- toire forpattern recognition of pathogens by the innate im- mune system is defined by cooperation between toll - like receptors显示文摘 | Ozinsky A Underhill DM Fontenot JD | 2000 | Proc Natl Acad Sci USA2000，97，13： | 1 |
| 16 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells显示文摘 | Fontenot JD Gavin MA Rudensky AY | 2003 | Nat Immunol2003，，4： | 1 |
| 17 | Foxp3 programs the development and function of CD4^+ CD25^+ regulatory T cells 显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，： | 1 |
| 18 | A function for interleukin 2 in Foxp3 - expressing regulatory T - cells 显示文摘 | Fontenot JD Rasmussen JP Gavin MA | 2005 | Nat Immunol2005，6，11： | 1 |
| 19 | A well adapted regulatory contrivance:regulatory T cell development and the forkhead family transcription factor Foxp3显示文摘 | Fontenot J D Rudensky A Y | 2005 | Nat Immunol2005，6，： | 1 |
| 20 | Expression and purification of recombinant human zona pellucida proteins显示文摘 | Harris JD Seid CA Fontenot GK | 1999 | Protein Express Purif1999，16，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员