|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 3 | Luger Dissolution ofammonium paratungstate tetrahydrate in agueous ammonia before and after low temperatuercalcination显示文摘 | 13,John W van Put Willem P CDuyvesteyn and Floris G J | 1991 | Hydrometallurgy1991，26，： | 1 |
| 4 | In vivo effects in melanoma of ROCK inhibition-induced fasl overexpression 显示文摘 | Teiti I Florie B Pich C | 2015 | Front Oneol2015，145，5： | 1 |
| 5 | Advances in 3-D forging process modeling显示文摘 | Slagter W J Florie C J L Venis A C J | 1991 | Journal of Computational Physics1991，92，1： | 1 |
| 6 | Influenza virus-induced NF-kappaB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase显示文摘 | Flory E Kunz M Scheller C | 2000 | J Biol Chem2000，275，12： | 1 |
| 7 | HLA-haplotypes and class Ⅱ molecular alleles in Sardinian and Italian patients with pemphigus vulgaris显示文摘 | Carcassi C Cottoni F Floris L | | 0，，： | 1 |
| 8 | Lunar Receiv- ing Laboratory:Unique requirements for handling lunar sam- pies and quarantining for back-contamination are provided显示文摘 | Mclane J C Jr King E A Jr Flory D A | | 0，，： | 1 |
| 9 | Nucleation and growth of zinc electrodeposited from acidic zinc solutions 显示文摘 | BESHORE A C FLORI B J SCHADE G | 1987 | J Applied Electrochemistry1987，17，： | 1 |
| 10 | Up-regulation of MET expression by alpha-melanocyte-stimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis显示文摘 | Beuret L Flori E Denoyelle C | 2007 | J Biol Chem2007，282，14： | 1 |
| 11 | Influenza A virus entry into cells lacking sialylated Nglycans显示文摘 | de Vries E de Vries R P Wienholts M J Floris C E Jacobs M S van den Heuvel A Rottier P J de Haan C A | 2012 | PNAS2012，109，19： | 1 |
| 12 | Linkage and association between plasmodium falciparum blood infeetion levels and chro- mosome 5q31-q33显示文摘 | Flori L Kumulungui B Aucan C | 2003 | Genes Immun2003，4，： | 1 |
| 13 | Influenza virus-in-duced NF-kappaB-dependent gene expression is mediated byover expression of viral proteins and involves oxidative radi-cals and activation of IkappaB kinase 显示文摘 | Flory E Kunz M Scheller C | 2000 | J Biol Chem2000，275，12： | 1 |
| 14 | HLA haplotypes and class Ⅱ molecular alleles in Sardinian and Italian patients with pemphigus vulgaris显示文摘 | Carcassi C Cottoni F Floris A | 1996 | Tissue Antigens1996，48，6： | 1 |
| 15 | Microwave measurements of stub tuners in two-dimensional photonic crystal waveguides显示文摘 | Sigalas M M Flory C A | 2002 | Phys Rev B2002，65，12： | 1 |
| 16 | The HLA-DRB1·0101 allele is responsible for HLA susceptibility to lichen ruber planus显示文摘 | Carcassi C Cottoni F Floris L | 1994 | Eur J Immunogenet1994，21，6： | 1 |
| 17 | Prevalence of-and risk factors for work disability in Dutch patients with inflammatory bowel disease显示文摘AIM To determine the prevalence of work disability in inflammatory bowel disease(IBD), and to assess risk factors associated with work disability.METHODS For this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical Centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population. Multivariate analyses were performed for work disability(sick leave, partial and full disability) and long-term full work disability(> 80% work disability for > 2 years).RESULTS Prevalence of work disability was higher in Crohn's disease(CD)(29%) and ulcerative colitis(UC)(19%) patients compared to the general Dutch population(7%). In all IBD patients, female sex, a lower education level, and extra-intestinal manifestations, were associated with work disability. In CD patients, an age > 40 years at diagnosis, disease duration > 15 years,smoking, surgical interventions, and anti-TNFα use were associated with work disability. In UC patients, an age > 55 years, and immunomodulator use were associated with work disability. In CD patients, a lower education level(OR = 1.62, 95%CI: 1.02-2.58), and in UC patients, disease complications(OR = 3.39, 95%CI: 1.09-10.58) were associated with long-term full work disability.CONCLUSION The prevalence of work disability in IBD patients is higher than in the general Dutch population. Early assessment of risk factors for work disability is necessary, as work disability is substantial among IBD patients. | Lieke M Spekhorst Bas Oldenburg Ad A van Bodegraven Dirk J de Jong Floris Imhann Andrea E van der Meulen-de Jong Marieke J Pierik Janneke C van der Woude Gerard Dijkstra Geert D'Haens Mark Lowenberg Rinse K Weersma Eleonora AM Festen 无 | 2017 | World Journal of Gastroenterology2017，23，46： | 1 |
| 18 | Cardial imaging by means of eletrocardiographically gated multisection spiral CT: initial experience 显示文摘 | Ohnesorge B Flory T Beeker C | 2000 | Radiology2000，217，2： | 1 |
| 19 | Effect of aging on rheological properties of lime putty显示文摘 | ATZENI C FARCI A FLORIS D | 2004 | J Am Ceram Soc2004，87，9： | 1 |
| 20 | Advances in 3-D forging process modeling显示文摘 | Florie C J L Venis A C J | 1991 | Journal of Computational Physics1991，92，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员