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| 1 | Therapy with stem cells in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) affects a part of the young population and has a strong impact upon quality of life. The underlying etiology is not known, and the existing treatments are not curative. Furthermore, a significant percentage of patients are refractory to therapy. In recent years there have been great advances in our knowledge of stem cells and their therapeutic applications. In this context, autologous hematopoietic stem cell transplantation(HSCT) has been used in application to severe refractory Crohn's disease(CD), with encouraging results. Allogenic HSCT would correct the genetic defects of the immune system, but is currently not accepted for the treatment of IBD because of its considerable risks. Mesenchymal stem cells(MSCs) have immune regulatory and regenerative properties, and low immunogenicity(both autologous and allogenic MSCs). Based on these properties, MSCs have been used via the systemic route in IBD with promising results, though it is still too soon to draw firm conclusions. Their local administration in perianal CD is the field where most progress has been made in recent years, with encouraging results. The next few years will be decisive for defining the role of such therapy in the management of IBD. | María del Pilar Martínez-Montiel Gonzalo Jesús Gómez-Gómez Ana Isabel Flores | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | Association of Nutrition Parameters Including Bioelectrical Impedance and Systemic Inflammatory Response With Quality of Life and Prognosis in Patients With Advanced Non-Small-Cell Lung Cancer: A Prospective Study显示文摘 | Karla Sánchez-Lara JennyG Turcott Eva Juárez Patricia Guevara Carolina Nú?ez-Valencia LuisF. O?ate-Oca?a Diana Flores Oscar Arrieta | 2012 | Nutrition and Cancer2012，，4： | 3 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Role of serum cytokine profile in ulcerative colitis assessment显示文摘 | Manuel Luis Rodríguez‐Perlvárez Valle García‐Sánchez Carlos Manuel Villar‐Pastor Raál González Eva Iglesias‐Flores Jordi Muntane Federico Gómez‐Camacho | 2012 | Inflamm Bowel Dis2012，，10： | 2 |
| 5 | Vitamin D Treatment and Mortality in Chronic Kidney Disease: A Systematic Review and Meta-Analysis显示文摘 | Duranton Flore Rodriguez-ortiz Maria E Duny Yohan Rodriguez Mariano Daur?s Jean-pierre Argil?s Angel | 2013 | American Journal of Nephrology2013，，3： | 2 |
| 6 | Digestion of biological materials using the microwave-assisted sample combustion technique 显示文摘 | Mesko M F Moraes D P Barin J S Dressler V L Knapp G Flores E M M | 2006 | Microchem Journal2006，82，： | 1 |
| 7 | Mechananical fregmentation and pharmacologic thrombolysis in massive pulmonary embolism显示文摘 | Fava M Logola S Flore S | 1997 | J Vasa Inter Radio1997，8，26： | 1 |
| 8 | Longterm followup of a randomized prospective trial comparing a standard 81 mg dose of intravesical bacille CalmetteGuérin with a reduced dose of 27 mg in superficial bladder cancer显示文摘 | MARTíNEZPIEIRO JA FLORES N ISORNA S | 2002 | BJU Int2002，89，7： | 1 |
| 9 | Insecticidal toxin in root exudates from Bt corn显示文摘 | SAXENA D FLORES S STOTZKY G | 1994 | Mol Ecol1994，3，： | 1 |
| 10 | The Relation between The Plasma Characteristic and The Corrosion Properties of TiN/Ti Mul- tilayers Deposited by Unbalanced Magnetron Sputtering 显示文摘 | FLORES M MUHL S ANDRADE E | 2010 | Thin Solid Films2010，433，： | 1 |
| 11 | Infl uence of preparation methods and Zr and Y promoters on Cu/ZnO catalysts used for methanol steam reforming显示文摘 | Sanches S G Flores J H Avillez R R D | 2012 | Int J Hydrogen Energy2012，37，8： | 1 |
| 12 | Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations 显示文摘 | Gao L Flores C Fan-Ma S | 2007 | Transl Res2007，150，1： | 1 |
| 13 | Influence of glycerol and chitosan on tapioca starch-based edible film properties 显示文摘 | Chillo S Flores S Mastromatteo M | 2008 | Journal of Food Engineering2008，88，： | 1 |
| 14 | Acrylic Bone Ce-ments Modified With Bioactive Filler显示文摘 | C F Jasso-Gastinel S G Enriquez J Flores | 2009 | Macromolecular Sym-posia2009，，： | 1 |
| 15 | Oxidant stress, im mune dysregulation, and vascular function in type I diabetes显示文摘 | NICOLLS M R HASKINS K FLORES S C | 2012 | Antioxid Redox Signal2012，9，7： | 1 |
| 16 | Variants of peach latent mosaic viroid inducing peach calico:uneven distribution in infected plants and requirements of the insertion containing the pathogenicity determinant显示文摘 | Delgado S Flores R | 2006 | J Gen Virol2006，87，： | 1 |
| 17 | Insecticidal Toxin in Root Exudates From Bt Corn显示文摘 | SAXENA D FLORES S STOTZKY G | 1999 | Nature1999，402，2： | 1 |
| 18 | Structural and magnetic properties of Fe-Al2O3 films显示文摘 | TEIXEIRAA S R BOFF M A S FLORES W H | 2001 | J Magn Magn Mater2001，233，1： | 1 |
| 19 | Microstructure formation of AI-Fe-Mn-Si aluminides by pressure-assisted reactive sintering of elemental powder mixtures 显示文摘 | FLORES A TOSCANO J A RODRIGUEZ S SALINAS A NAVA E | 2009 | Advanced Materials Research2009，68，： | 1 |
| 20 | Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity显示文摘 | Gago S Flores R | 2003 | EMBO J2003，22，： | 1 |
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