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| 1 | Association of Nutrition Parameters Including Bioelectrical Impedance and Systemic Inflammatory Response With Quality of Life and Prognosis in Patients With Advanced Non-Small-Cell Lung Cancer: A Prospective Study显示文摘 | Karla Sánchez-Lara JennyG Turcott Eva Juárez Patricia Guevara Carolina Nú?ez-Valencia LuisF. O?ate-Oca?a Diana Flores Oscar Arrieta | 2012 | Nutrition and Cancer2012，，4： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Neurotrophic fragments as therapeutic alternatives to ameliorate brain aging显示文摘Aging is a global phenomenon and a complex biological process of all living beings that introduces various changes.During this physiological process,the brain is the most affected organ due to changes in its structural and chemical functions,such as changes in plasticity and decrease in the number,diameter,length,and branching of dendrites and dendritic spines.Likewise,it presents a great reduction in volume resulting from the contraction of the gray matter.Consequently,aging can affect not only cognitive functions,including learning and memory,but also the quality of life of older people.As a result of the phenomena,various molecules with notable neuroprotective capacity have been proposed,which provide a therapeutic alternative for people under conditions of aging or some neurodegenerative diseases.It is important to indicate that in recent years the use of molecules with neurotrophic activity has shown interesting results when evaluated in in vivo models.This review aims to describe the neurotrophic potential of molecules such as resveratrol(3,5,4′-trihydroxystilbene),neurotrophins(brain-derived neurotrophic factor),and neurotrophic-type compounds such as the terminal carboxyl domain of the heavy chain of tetanus toxin,cerebrolysin,neuropeptide-12,and rapamycin.Most of these molecules have been evaluated by our research group.Studies suggest that these molecules exert an important therapeutic potential,restoring brain function in aging conditions or models of neurodegenerative diseases.Hence,our interest is in describing the current scientific evidence that supports the therapeutic potential of these molecules with active neurotrophic. | Itzel Ortiz Flores Samuel Treviño Alfonso Díaz | 2023 | Neural Regeneration Research2023，18，1： | 2 |
| 4 | Plant life-form and germination in a Mexican inter-tropical desert: Effects of soil water potential and temperature 显示文摘 | FLORES J BRIONES O | 2001 | Journal of Arid Environ- ments2001，47，4： | 1 |
| 5 | Plant life-form and germination in Mexican inter-tropical desert:effects of soil water potential and temperature 显示文摘 | Flores J Briones O | 2001 | Journal of Arid Environments2001，47，： | 1 |
| 6 | Friction-stir welding: microstrucmral characterization 显示文摘 | Murr L E Flores R D Flores O V | 1998 | Mater Res Innoval1998，35，1： | 1 |
| 7 | The effectiveness of grafting to improve salt tolerance in tomato when an 'excluder' genotype is used as scion显示文摘 | Martinez-Rodriguez M M Estan M T Moyano E Garcia- Abellan J O Flores F B Campos J F A1-Azzawi M J Flowers T J Bolarin M C | 2008 | Environmental & Experimental Botany2008，63，1： | 1 |
| 8 | The integration of manufacturing and marketing/sales decisions : impact on organizational performance 显示文摘 | O'Leary-Kelly SW Flores BE | 2002 | Journal of Operations Management2002，20，3： | 1 |
| 9 | Gamma irradiation induced degradation of orange peels 显示文摘 | Sanchez O R Balderas H P Flores R N | 2012 | Energies2012，5，8： | 1 |
| 10 | Relationships between NOS2 and HO-1 in liver of rats with chronic bile duct ligation 显示文摘 | Flores O Criado M Sanchez-Rodriguez A | 2005 | Hepatol Res2005，32，1： | 1 |
| 11 | Corrosion of a Zn-Al-Cu alloy coated with TiN/Ti films显示文摘 | FLORES M BLANCO O MUHL S | 1998 | Surf Coat Technol1998，，： | 1 |
| 12 | A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties显示文摘 | Olsen D B Eldrup AB Bartholomew L Bhat B Bosserman M R Ceccacci A Colwell L F Fay J F Flores O A Getty K L Grobler J A LaFemina R L Markel E J Migliaccio G Prhavc M Stahlhut M W Tomassini J E MacCoss M Hazuda D J Carroll S S | | 0，，10： | 1 |
| 13 | Corrosion of a Zn AI-Cu Alloy Coated with TiN/Ti Films显示文摘 | Flores M Blanco O Muhl S | 1998 | Surface and Coatings Technology1998，108，4： | 1 |
| 14 | Structural, mor- phological and interracial characterization of A1-Mg/TiC com- posites显示文摘 | Contreras A Angdes-Chdvez C Flores O | 2006 | Materials Characterization2006，，58： | 1 |
| 15 | Abnormal Grain Growth of Austenite in a V-Nb Microalloyed Steel 显示文摘 | Flores O Martinez L | 1997 | Journal of Materials Science1997，32，4： | 1 |
| 16 | Sodium phthalamates as corrosion inhibitors for carbon steel in aqueous hy- drochloric acid solution显示文摘 | Flores EA Olivares O Likhanova NV | 2011 | Corrosion Science2011，53，12： | 1 |
| 17 | Glycyrrhizic acid inhibits virus growth and inactivates virus particles 显示文摘 | Pompei R Flore O Marccialis M A | 1979 | Nature1979，281，5733： | 1 |
| 18 | Swine and ruminant pestiviruses require the same cellular factors to enter bovine cells 显示文摘 | Flores E F Krentz L C Doins R O | 1996 | J Gen Virol1996，77，： | 1 |
| 19 | Effcient identification of clinically relevant candida yeast species by use of an assay combining panfungal loop-mediated isothermal DNA amplifcation with hybridization to species-specic oligonucleotide probes显示文摘 | Inacio J Flores O Martins I S | 2008 | J Clin Microbiol2008，46，2： | 1 |
| 20 | Fc gamma receptor Ⅱ B on dendritic cells enforces-peripheral tolerance by inhibiting effector T cell resppnses显示文摘 | DESAI D D HARBERS S O FLORES M | 2007 | J Immunol2007，178，： | 1 |
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