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| 1 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 2 | An atomic force microscopy study on the effect of bleaching agents on enamel surface显示文摘 | Hegedus C Bistey T Flora Nagy E | 1999 | J Dent1999，27，7： | 1 |
| 3 | An atomic force microscopy study on the effect of bleaching agents on enamel surface 显示文摘 | HEGEDUS C BISTEY T FLORA - NAGY E | 1999 | Journal of Dentistey1999，27，： | 1 |
| 4 | Interplay between Helicobacter pylori and host gene polymorphisms in inducing oxidative DNA damage in the gastric mucosa显示文摘 | Izzotti A de Flora S Cartiglia C | 2007 | Carcinogenesis2007，28，4： | 1 |
| 5 | Risk of second cancer after treatment of aggressive non-Hodgkin's lymphoma; an EORTC cohort study显示文摘 | Elizabeth C M Noordijk EM Flora EL | 2006 | Haematologica2006，91，11： | 1 |
| 6 | Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcyste,ne treatment显示文摘 | De Flora Grassr C Carati L | 1997 | Eur Respir J1997，10，： | 1 |
| 7 | Hedge ratios in greek stock index futures market 显示文摘 | Floras C Vougas D | 2004 | Applied Financial Economics2004，14，15： | 1 |
| 8 | Epidermal growth factor recep- tor (EGFR) gene copy number in colorectal adenoma-carcinoma pro- gression显示文摘 | Flora M Piana S Bassano C | 2012 | Cancer Genet2012，205，12： | 1 |
| 9 | Organochlorine compounds in ice melt water from Italian Alpine rivers 显示文摘 | Villa S Negrelli C Finizio A Flora O Vighi M | 2006 | Ecotoxicology & Enviromnental Safety2006，63，： | 1 |
| 10 | Alkaloid metabolism in wounded Catharanthus ros eus seedlings 显示文摘 | FLORA F V PECH M C GARCFA Y M | 2004 | Plant Physiology and Biochemistry2004，42，78： | 1 |
| 11 | Visualisation of cavitation in diesel engine injectors显示文摘 | C Arcoumanis M Gavaises H Flora H Roth | 2001 | Mécanique & Industrie2001，，5： | 1 |
| 12 | Development of a model to select plants with optimum metal phytoextration potential显示文摘 | Sebasti6n D G Flora A V Emma F C | 2011 | Environmental Science and Pollution Research2011，18，6： | 1 |
| 13 | Growers' perceptions and acceptance of soil quality indices 显示文摘 | Andrews S S Flora C B Mitchell J P | 2003 | Geoderma2003，114，： | 1 |
| 14 | Effect of soybean 7S protein fractions, obtained from germinated and nongerminated seeds, on dough theological properties and bread quality显示文摘 | EMIGDIO C LOPEz G FLORA B | 2012 | Food Bioprocess Technology2012，5，1： | 1 |
| 15 | Comparison of herbal therapy for liver disease显示文摘 | Berk BS Chaya C Benner KC Flora KD | 1999 | Hepatology1999，30，： | 1 |
| 16 | An automated growth measurement system for leafy vegetables 显示文摘 | FLORA YEH Y H LAI T C LIU T M | 2014 | Biosystems engineering2014，117，： | 1 |
| 17 | Growers' perceptions and acceptance of soil quality indices显示文摘 | Andrews S S Flora C B Mitchell J P Karlen D L | 2003 | Geoderma2003，114，： | 1 |
| 18 | Does impaired explain the spatial uncertainty of amblyopes? 显示文摘 | Barbeito R Bedell contrast sensitivity H E Flora M C | 1988 | Investigative Ophthalmology Visual Science1988，29，2： | 1 |
| 19 | Visualisation of cavitation in diesel engine injectors显示文摘 | Arcoumanis C Gavaises M Flora H | 2001 | Mecanique & Industries2001，，2： | 1 |
| 20 | Active tuberculosis in inflammatory bowel disease patients under treatment from an endemic area in Latin America显示文摘BACKGROUND There has been an increase in cases of inflammatory bowel disease(IBD)in recent years.There is also greater access and availability of immunosuppressive and biological agents,which increase the risk of opportunistic infection despite improving the quality of life and promoting mucosal healing.Tuberculosis(TB)remains a public health problem,and it has a high incidence in several countries.Therefore,knowledge of the risk of developing TB in patients with IBD is important.AIM To evaluate the risk of active TB in patients with IBD under treatment from an endemic area in Latin America.METHODS A standard questionnaire included demographic variables,clinical aspects of IBD disease,history of active TB during treatment,active TB characteristics and evolution,initial screening and results and time from the start of anti-tumor necrosis factor alpha(TNFα)to TB development.RESULTS Azathioprine,anti-TNFα and the combination of these two drugs were associated with a higher risk of active TB incidence.The TNFα blockers increased the relative risk of developing active TB compared to other treatments.All four multivariable models showed that the use of TNFα blockers alone or in combination with azathioprine was an important risk factor for the incidence of active TB.After adjustment for sex,age,type of IBD and latent TB,anti-TNFα with azathioprine increased the relative risk to 17.8 times more than conventional treatment.Late TB,which was diagnosed 3 mo after the start of anti-TNFα,was the most frequent.CONCLUSION Treatment with anti-TNFα increased the risk of active TB in IBD patients from an endemic area in Latin America.This risk was increased when anti-TNFα was combined with azathioprine.The time from the beginning of the treatment to the active TB diagnosis suggests a new TB infection. | Flora Maria Lorenzo Fortes Ney Boa Sorte Victor D Mariano Laila D Andrade Fernanda A Oliveira Monique CA Santos Claudia Ivanilda N dos Santos Catharina A Passos Mila P Pacheco Valdiana C Surlo Neogelia P de Almeida Jaciane AM Fontes Andrea M Pimentel Raquel Rocha Genoile Oliveira Santana | 2020 | World Journal of Gastroenterology2020，26，44： | 1 |
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