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| 1 | Cytotoxic effect of Spirulina platensis extracts on human acute leukemia Kasumi-1 and chronic myelogenous leukemia K-562 cell lines显示文摘Objective: To evaluate the cytotoxic effects of Spirulina platensis extracts on acute leukemia Kasumi-1 and chronic leukemia K-562 cancer cell lines.Methods: Various concentrations of Spirulina platensis extracts(0.25–50.00 mg/m L)obtained with different solvents were used to treat cell lines for 72 h. For cytotoxic effect studies, cell viability test with trypan blue solution, MTT assay and microscopic cytomorphological assessment were done.Results: Spirulina extract obtained with 70% ethanol showed significant cytotoxicity in K562 and Kasumi-1 cell lines. With trypan blue solution, IC_(50) values were found to be4.64 mg/m L for K-562 and 3.68 mg/m L for Kusumi-1 cell lines. Spirulina aqueous extract also showed cytotoxicity with trypan blue method, at a slightly higher dose; where IC_(50) values were 12.68 mg/m L for K-562 and 2.13 mg/m L for Kusumi-1 cell lines. The IC_(50) values were found 0.40 mg/m L for K-562 and 0.31 mg/m L for Kusumi-1 cell lines for the 70% ethanol extract according to the MTT assay. Spirulina extract obtained with water also showed cytotoxicity but the dose was a little higher where IC_(50) values were15.77 mg/m L for K-562 and 9.44 mg/m L for Kusumi-1 cell lines. The effect of cytotoxicity with ethanol extract is quite comparable with that observed for cyclophosphamide, which is a chemical used as anticancer agent.Conclusions: The cytotoxicity exhibited by Spirulina extract to cancer cell lines might be due to the presence of phytopigments(carotenoids, chlorophyll, phycocyanin) as well as polysaccharides that were reported previously as constituents of the extract. So crude extracts of Spirulina can be used as a source to develop anticancer drugs. | Flor Yohana Flores Hernandez Sanghamitra Khandual Inocencia Guadalupe Ramírez López | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，1： | 4 |
| 2 | NdCoO3 perovskite as possible candidate for CO-sensors:thin films synthesis and sensing properties显示文摘 | Malavasi L Tealdi C Flor G Chiodelli G Cervetto V Montenero A Borella M | | 0，，02： | 1 |
| 3 | Coloplus, a new product based on bovine colostrum, alleviates HIV-associated diarrhea显示文摘 | Florén CH Chinenye S Elfstrand L | 2006 | Scand J Gastroenterol2006，41，6： | 1 |
| 4 | Regulation in a context of limited com- petition: Aport case 显示文摘 | Defilippi E Flor L | 2008 | Transportation Research Part A: Policy and Practice2008，42，5： | 1 |
| 5 | Identification of innovating finns through technological innovation indicators: An application to the Spanish ceramic tile industry 显示文摘 | FLOR M L OLTRA M J | 2004 | Research Policy2004，，33： | 1 |
| 6 | Phantom limb pain: a case of maladaptive CNS plasticity?显示文摘 | Flor H Nikolajsen L Staehelin JT | 2006 | Nat Rev Neurosci2006，7，11： | 1 |
| 7 | Vesselplasty:a new technical approach to treat symptomatic vertebral compression fractures显示文摘 | Flors L Lonjedo E Leiva-Salinas C | 2009 | AJR2009，193，1： | 1 |
| 8 | Urinary β-trace protein as a new renal tubular marker显示文摘 | Vynckier L J Floré KM Delanghe SE | | 0，，06： | 1 |
| 9 | Phantom limb pain: a case of maladaptive CNS plasticity显示文摘 | Flor H Nikolajsen L Staehelin Jensen T | 2006 | Nat Rev Neurosci2006，7，11： | 1 |
| 10 | Ventilationbased segmentation of the lungs using hyperpolarized3 He MRI显示文摘 | Tustison NJ Avants BB Flors L | 2011 | Journal of Magnetic Resonance Imaging2011，34，4： | 1 |
| 11 | Management of chronic diarrhea in HIV-infected patients: current treatment options, challenges, and future directions显示文摘 | Elfstrand L Florén CH | 2010 | HIV AIDS (Auckl)2010，2，： | 1 |
| 12 | 显示文摘 | Malavasi L Tealdi C Flor G | 2005 | Sensors and Acruators B2005，105，： | 1 |
| 13 | Iron and copper chelation by flavonoids:an electrospray mass spectrometry study显示文摘 | Fernandez M T Mira M L Florêncio M H | | 0，，02： | 1 |
| 14 | Endoleak detection after endovaseular repair of thoracic aortic aneurysm using dual- source dual-energy CT: suitable scanning protocols and potential radiation dose reduction显示文摘 | Flors L Leiva-Salinas C Norton P T | 2013 | AJR2013，200，2： | 1 |
| 15 | biD CT angiography and MR angiography of nonatherosclerotic renal artery disease显示文摘 | Flors L Leiva-Salinas C Ahmad EA | | 0，，06： | 1 |
| 16 | Identification of Innovating Firms through Technological Innovation Indicators: an Application to the Spanish Ceramic tile Industry 显示文摘 | FLOR M L OLTRA M J | 2004 | Research Policy2004，，33： | 1 |
| 17 | Vesselplasty: a new technical approach to treat symptomatic vertebral compression fractures 显示文摘 | Flors L Lonjedo E Leiva-Salinas C | 2009 | AJR2009，193，1： | 1 |
| 18 | Vesselplasty:a new technical approach to treat symptomatic vertebral compression fractures显示文摘 | Flors L Lonjedo E Leiva-Salinas C | | 0，，： | 1 |
| 19 | Ironand copper chelation by flavonoids:an electrospray massspectrometry study显示文摘 | FERNANDEZ M T MIRA M L FLORNCIO M H | 2002 | Journal of Inorganic Biochemistry2002，92，： | 1 |
| 20 | Phantom limb pain: a case of maladaptive CNS plasticity 显示文摘 | Flor H Nikolajsen L Staehelin J T | 2006 | Nature Reviews Neuroscience2006，7，11： | 1 |
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