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| 1 | Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: A randomized controlled study显示文摘AIM: To evaluate treatment safety and hemodynamic changes during a single 6-h treatment with the Prometheus? liver assist system in a randomized, controlled study. METHODS: Twenty-four patients were randomized to either the study group or to one of two control groups: Fractionated Plasma Separation Adsorption and Dialysis, Prometheus? system (Study group; n = 8); Molecular Adsorbent Recirculation System (MARS)? (Control group 1, n = 8); or hemodialysis (Control group 2; n = 8). All patients included in the study had decompensated cirrhosis at the time of the inclusion into the study. Circulatory changes were monitored with a Swan-Ganz catheter and bilirubin and creatinine were monitored as measures of protein-bound and water-soluble toxins. RESULTS: Systemic hemodynamics did not differ between treatment and control groups apart from an increase in arterial pressure in the MARS group (P = 0.008). No adverse effects were observed in any of the groups. Creatinine levels significantly decreased in the MARS group (P = 0.03) and hemodialysis group (P = 0.04). Platelet count deceased in the Prometheus group (P = 0.04).CONCLUSION: Extra-corporal liver support with Prometheus is proven to be safe in patients with end- stage liver disease but does not exert the beneficial effects on arterial pressure as seen in the MARS group. | Thomas Dethloff Flemming Tofteng Hans-Jorgen Frederiksen Michael Hojskov Bent Adel Hansen Fin Stolze Larsen | 2008 | World Journal of Gastroenterology2008，14，13： | 4 |
| 2 | WJD 5^(th) Anniversary Special Issues(2): Type 2 diabetes Effects of exercise training on mitochondrial function in patients with type 2 diabetes显示文摘Type 2 diabetes is characterized by a decreased ability of insulin to facilitate glucose uptake into insulin sensitive tissue,i.e.,skeletal muscle.The mechanism behind this is at the moment unresolved.It has been suggested that increased amount of lipids inside the skeletal muscle(intramuscular triglyceride,diacylglycerol and ceramides)will impair insulin action in skeletal muscle,but data are not consistent in the human literature.It has also been hypothesized that the impaired insulin sensitivity is due to a dysfunction in the mitochondria resulting in an impaired ability to oxidize lipids,but the majority of the literature is not supporting this hypothesis.Recently it has been suggested that the production of reactive oxygen species play an essential role in skeletal muscle insulin sensitivity.It is well accepted that physical activity(endurance,strength and high intensity training)improves insulin sensitivity in healthy humans and in patients with type 2 diabetes.Whether patients with type 2 diabetes have the same beneficial effects(same improvement)as control subjects,when it comes to regular physical activity in regard to mitochondrial function,is not established in the literature.This review will focus only on the effect of physical activity on skeletal muscle(mitochondrial function)in patients with type 2 diabetes. | Steen Larsen Stinna Skaaby J rn W Helge Flemming Dela | 2014 | World Journal of Diabetes2014，5，4： | 2 |
| 3 | Deposition and high temperature corrosion in a 10 MW straw fired boiler显示文摘 | Hanne Philbert Michelsen Flemming Frandsen Kim Dam-Johansen Ole Hede Larsen | 1997 | Fuel Processing Technology1997，，1： | 2 |
| 4 | Final results of a long-term, clinical follow-up in fatty liver patients显示文摘 | Sanne Dam-Larsen Ulrik Becker Maria-Benedicte Franzmann Klaus Larsen Per Christoffersen Flemming Bendtsen | 2009 | Scandinavian Journal of Gastroenterology2009，，10： | 1 |
| 5 | Cyclodextrin modified hydrogels of PVP/PEG for sustained drug release显示文摘 | Anne Louise Nielsen Flemming Madsen Kim Lambertsen Larsen | 2009 | Drug Delivery2009，，2： | 1 |
| 6 | Differences in crystalline cellulose modification due to degradation by brown and white rot fungi显示文摘 | Anne Christine Steenkjaer Hastrup Caitlin Howell Flemming Hofmann Larsen | 2012 | Fungal Biology2012，6，： | 1 |
| 7 | Cerebral oxygenation determined by near-infrared spectrophotometry in patients with fulminant hepatic failure显示文摘 | Henning Bay Nielsen Flemming Tofteng Lars Peter Wang Fin Stolze Larsen | 2002 | Journal of Hepatology2002，，2： | 1 |
| 8 | Cerebral microdialysis in patients with fulminant hepatic failure显示文摘 | Flemming Tofteng Linda Jorgensen Bent Adel Hansen Peter Ott Jens Kondrup Fin Stolze Larsen | 2002 | Hepatology2002，，6： | 1 |
| 9 | Monitoring extracellular concentrations of lactate, glutamate, and glycerol by in vivo microdialysis in the brain during liver transplantation in acute liver failure显示文摘 | Flemming Tofteng Fin Stolze Larsen | 2002 | Liver Transplantation2002，，3： | 1 |
| 10 | Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects显示文摘 | Steen Larsen Joachim Nielsen Christina Neigaard Hansen Lars Bo Nielsen Flemming Wibrand Nis Stride Henrik Daa Schroder Robert Boushel J?rn Wulff Helge Flemming Dela Martin Hey‐Mogensen | 2012 | The Journal of Physiology2012，，14： | 1 |
| 11 | Histological characteristics and prognosis in patients with fatty liver显示文摘 | Sanne Dam-Larsen Maria-Benedicte Franzmann Per Christoffersen Klaus Larsen Ulrik Becker Flemming Bendtsen | 2005 | Scandinavian Journal of Gastroenterology2005，，4： | 1 |
| 12 | Monitoring extracellular concentrations of lactate, glutamate, and glycerol by in vivo microdialysis in the brain during liver transplantation in acute liver failure显示文摘 | Flemming Tofteng Fin Stolze Larsen | 2002 | Liver Transplantation2002，，3： | 1 |
| 13 | Final results of a long-term, clinical follow-up in fatty liver patients显示文摘 | Sanne Dam-Larsen Ulrik Becker Maria-Benedicte Franzmann Klaus Larsen Per Christoffersen Flemming Bendtsen | 2009 | Scandinavian Journal of Gastroenterology2009，，10： | 1 |
| 14 | Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects显示文摘 | Steen Larsen Joachim Nielsen Christina Neigaard Hansen Lars Bo Nielsen Flemming Wibrand Nis Stride Henrik Daa Schroder Robert Boushel J?rn Wulff Helge Flemming Dela Martin Hey‐Mogensen | 2012 | The Journal of Physiology2012，，14： | 1 |
| 15 | Systemic response in patients undergoing laparoscopic cholecystectomy using gasless or carbon dioxide pneumoperitoneum: a randomized study显示文摘 | Dr. Jens Fromholt Larsen Per Ejstrud Flemming Svendsen Vivi Pedersen Finn Redke | 2002 | Journal of Gastrointestinal Surgery2002，，4： | 1 |
| 16 | Quasi- Markets in Employment Policy:Do They Deliver on Promises显示文摘 | Thomas Bredgaard Flemming Larsen | 2008 | Social Policy and Society2008，，7： | 1 |
| 17 | In situ analysis of trace elements in quartz by using laser ablation inductively coupled plasma mass spectrometry 显示文摘 | Flem B Larsen R B Grimstvedt A Mansfeld J | 2002 | Chemical Geology2002，182，24： | 1 |
| 18 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure显示文摘 | Peter Nissen Bjerring John Hauerberg Linda J?rgensen Hans-J?rgen Frederiksen Flemming Tofteng Bent Adel Hansen Fin Stolze Larsen | 2010 | Journal of Hepatology2010，，6： | 1 |
| 19 | Quasi-Markets in Employment Policy:Do They Deliver on Promises显示文摘 | Thomas Bredgaard Flemming Larsen | | 0，，03： | 1 |
| 20 | Randomized comparison of conventional and gasless laparoscopic cholecystectomy: Operative technique, postoperative course, and recovery显示文摘 | Jens Fromholt Larsen M.D. Per Ejstrud M.D. Joergen U. Kristensen M.D. Flemming Svendsen M.D. Finn Redke M.D. Vivi Pedersen M.D | 2001 | Journal of Gastrointestinal Surgery2001，，3： | 1 |
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