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| 1 | Diffusion-weighted imaging of pancreatic cancer显示文摘Magnetic resonance imaging(MRI) is a reliable and accurate imaging method for the evaluation of patients with pancreatic ductal adenocarcinoma(PDAC). Diffusion-weighted imaging(DWI) is a relatively recent technological improvement that expanded MRI capabilities, having brought functional aspects into conventional morphologic MRI evaluation. DWI can depict the random diffusion of water molecules within tissues(the so-called Brownian motions). Modifications of water diffusion induced by different factors acting on the extracellular and intracellular spaces, as increased cell density, edema, fibrosis, or altered functionality of cell membranes, can be detected using this MR sequence. The intravoxel incoherent motion(IVIM) model is an advanced DWI technique that consent a separate quantitative evaluation of all the microscopic random motions that contribute to DWI, which are essentially represented by molecular diffusion and blood microcirculation(perfusion). Technological improvements have made possible the routine use of DWI during abdominal MRI study. Several authors have reported that the addition of DWI sequence can be of value for the evaluation of patients with PDAC, especially improving the staging; nevertheless, it is still unclear whether and how DWI could be helpful for identification, characterization, prognostic stratification and follow-up during treatment. The aim of this paper is to review up-to-date literature data regarding the applications of DWI and IVIM to PDACs. | Riccardo De Robertis Paolo Tinazzi Martini Emanuele Demozzi Flavia Dal Corso Claudio Bassi Paolo Pederzoli Mirko D'Onofrio | 2015 | World Journal of Radiology2015，7，10： | 14 |
| 2 | Nuclear imaging in detection and monitoring of cardiotoxicity显示文摘Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and outcome.The coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor agents.Left ventricular dysfunction is the most typical manifestation and can lead to heart failure.Left ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial injury.Early non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic effects.Although echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical manifestation.The aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity. | Carmen D’Amore Paola Gargiulo Stefania Paolillo Angela Maria Pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino Marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi | 2014 | World Journal of Radiology2014，6，7： | 2 |
| 3 | Antioxidative responses of Calendula officinalis under salinity conditions显示文摘 | Nader Chaparzadeh Maria Lucia D’Amico Ramazan-Ali Khavari-Nejad Riccardo Izzo Flavia Navari-Izzo | 2004 | Plant Physiology and Biochemistry2004，，9： | 2 |
| 4 | Body fat and insulin resist- ance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome 显示文摘 | Flavia T Romolo D Roberto C | 2009 | Eur J Endocrinol2009，161，5： | 1 |
| 5 | Biofilm development and cell death in the marine bacterium Pseudoalteromona tunicate显示文摘 | ANNE M P FLAVIA E DORALYN D S | 2004 | Applied and Environmental Microbiology2004，7，70： | 1 |
| 6 | Synthesis and preli- minary pharmacological evaluation of new (±) 1, 4-Naph- thoquinones structurally related to lapachol 显示文摘 | Alcides JM Camilla D Flavia V | 2002 | Bioorg Med Chem2002，10，8： | 1 |
| 7 | Rotordynamic force prediction of centrifugal compressor impellers using computational fluid dynamics 显示文摘 | Moore J J Ransom D L Flavia Viana | 2011 | ASME Journal of Engineering for Gas Turbines and Power2011，133，04： | 1 |
| 8 | Rapid dehydration of grape berries dampens the post-ripening transcriptomic program and the metabolite profile evolution显示文摘The postharvest dehydration of grape berries allows the concentration of sugars and other solutes and promotes the synthesis of metabolites and aroma compounds unique to high-quality raisin wines such as the passito wines made in Italy.These dynamic changes are dependent on environmental parameters such as temperature and relative humidity,as well as endogenous factors such as berry morphology and genotype,but the contribution of each variable is not well understood.Here,we compared berries subjected to natural or accelerated dehydration,the latter driven by forced air flow.We followed the evolution of transcript and metabolite profiles and found that accelerated dehydration clearly dampened the natural transcriptomic and metabolomic programs of postharvest berries.We found that slow dehydration over a prolonged duration is necessary to induce gene expression and metabolite accumulation associated with the final quality traits of dehydrated berries.The accumulation of key metabolites(particularly stilbenoids)during postharvest dehydration is inhibited by rapid dehydration conditions that shorten the berry life time. | Sara Zenoni Alessandra Amato Erica D’Incà Flavia Guzzo Giovanni Battista Tornielli | 2020 | Horticulture Research2020，7，1： | 1 |
| 9 | Starch, sugarcane bagasse fi- bre,and polyvinyl alcohol effects on extruded foam properties:a mixture design approach显示文摘 | Suzana M Flavia D Maria V | 2010 | Industrial Crop Product2010，32，3： | 1 |
| 10 | Protective role of antimannan and anti - aspartyl proteinase antibodies in an experimental model of Candida albicans vaginitis in rats 显示文摘 | Flavia D B Maria B Daniela A | 1997 | Infection and Immunity1997，65，8： | 1 |
| 11 | Highly active heterogeneous Fenton-like systems based on FeO/Fe3O4 composites prepared by controlled reduction of iron oxides显示文摘 | Costa RC C Flavia C C M Ardisson J D | | 0，，： | 1 |
| 12 | BDNF-TrkB path way mediates NMDA receptor NR2B subunit phosphoryla tion in the supraoptic nuclei following progressive dehydra tion显示文摘 | Flavia RC Joseph DW Mayurika D | 2011 | J Neuroendocrinol2011，23，10： | 1 |
| 13 | Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice显示文摘 | Giuseppe D’Antona Maurizio Ragni Annalisa Cardile Laura Tedesco Marta Dossena Flavia Bruttini Francesca Caliaro Giovanni Corsetti Roberto Bottinelli Michele O. Carruba Alessandra Valerio Enzo Nisoli | 2010 | Cell Metabolism2010，，4： | 1 |
| 14 | Biofilm development and cell death in the marine bacterium Pseudoalteromonas tunicate显示文摘 | ANNE M P FLAVIA E DORALYN D S | 2004 | Appl Environ Microbiol2004，7，70： | 1 |
| 15 | Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice显示文摘 | Giuseppe D’Antona Maurizio Ragni Annalisa Cardile Laura Tedesco Marta Dossena Flavia Bruttini Francesca Caliaro Giovanni Corsetti Roberto Bottinelli Michele O. Carruba Alessandra Valerio Enzo Nisoli | 2010 | Cell Metabolism2010，，4： | 1 |
| 16 | Physicochemical and nutritional properties of pigmented rice subjected to different degrees of milling 显示文摘 | Flavia Fernandes Paiva Vanier N L Berrios J D J | 2014 | Journal of Food Composition & Analysis2014，35，1： | 1 |
| 17 | Spectral shape-based as-sessment of SDOF nonlinear response to real,adjusted andartificial ceeelerograms 显示文摘 | Iunio I Flavia D L Edoardo C | 2010 | Engineering Structrues2010，32，： | 1 |
| 18 | Efficacy and specifici- ty of intensive cognitive rehabilitation of attention and execu- tive functions in multiple sclerosis显示文摘 | Flavia M Stampatori C Zanotti D | 2010 | J Neurol Sci2010，288，12： | 1 |
| 19 | An application of chitosan as a coagulant/flocculant in a microfiltration process of natural water显示文摘 | ROSANGELA B CHRISTIAN B FLAVIA V D S | 2009 | Desalination2009，245，123： | 1 |
| 20 | Glucose transporter expression in the human colon显示文摘AIM To investigate by immunostaining glucose transporter expression in human colorectal mucosa in controls and patients with inflammatory bowel disease(IBD). METHODS Colorectal samples were obtained from patients undergoing lower endoscopic colonoscopy or rectosigmoidoscopy. Patients diagnosed with ulcerativecolitis(n = 18) or Crohn's disease(n = 10) and scheduled for diagnostic colonoscopy were enrolled. Patients who underwent colonoscopy for prevention screening of colorectal cancer or were followed-up after polypectomy or had a history of lower gastrointestinal symptoms were designated as the control group(CTRL, n = 16). Inflammatory status of the mucosa at the sampling site was evaluated histologically and/or endoscopically. A total of 147 biopsies of colorectal mucosa were collected and processed for immunohistochemistry analysis. The expression of GLUT2, SGLT1, and GLUT5 glucose transporters was investigated using immunoperoxidase labeling. To compare immunoreactivity of GLUT5 and LYVE-1, which is a marker for lymphatic vessel endothelium, doublelabeled confocal microscopy was used. RESULTS Immunohistochemical analysis revealed that GLUT2, SGLT1, and GLUT5 were expressed only in short epithelial portions of the large intestinal mucosa. No important differences were observed in glucose transporter expression between the samples obtained from the different portions of the colorectal tract and between the different patient groups. Unexpectedly, GLUT5 expression was also identified in vessels, mainly concentrated in specific areas where the vessels were clustered. Immunostaining with LYVE-1 and GLUT5 antibodies revealed that GLUT5-immunoreactive(-IR) clusters of vessels were concentrated in areas internal to those that were LYVE-1 positive. GLUT5 and LYVE-1 did not appear to be colocalized but rather showed a close topographical relationship on the endothelium. Based on their LYVE-1 expression, GLUT5-IR vessels were identified as lymphatic. Both inflamed and noninflamed mucosal colorectal tissue biopsies from the IBD and CTRL patients showed GLUT5-IR clusters of lymphatic vessels. CONCLUSION Glucose transporter immunoreactivity is present in colorectal mucosa in controls and IBD patients. GLUT5 expression is also associated with lymphatic vessels. This novel finding aids in the characterization of lymphatic vasculature in IBD patients. | Flavia Merigo Alessandro Brandolese Sonia Facchin Silvia Missaggia Paolo Bernardi Federico Boschi Renata D’Incà Edoardo Vincenzo Savarino Andrea Sbarbati Giacomo Carlo Sturniolo | 2018 | World Journal of Gastroenterology2018，24，7： | 0 |
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