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| 1 | Imaging of bone metastasis: An update显示文摘Early detection of skeletal metastasis is critical for accurate staging and optimal treatment. This paper briefly reviews our current understanding of the biological mechanisms through which tumours metastasise to bone and describes the available imaging methods to diagnose bone metastasis and monitor response to treatment. Among the various imaging modalities currently available for imaging skeletal metastasis, hybrid techniques whichfuse morphological and functional data are the most sensitive and specific, and positron emission tomography(PET)/computed tomography and PET/magnetic resonance imaging will almost certainly continue to evolve and become increasingly important in this regard. | Gerard J O'Sullivan Fiona L Carty Carmel G Cronin | 2015 | World Journal of Radiology2015，7，8： | 10 |
| 2 | Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery显示文摘AIM: To investigate the impact of minor abdominal surgery on the caecal microbial population and on markers of gut inflammation.METHODS: Four week old piglets were randomly allocated to a no-surgery 'control' group(n = 6) or a 'transection surgery' group(n = 5).During the transection surgery procedure, a conventional midline incision of the lower abdominal wall was made and the small intestine was transected at a site 225 cm proximal to the ileocaecal valve, a 2 cm segment was removed and the intestine was re-anastomosed.Piglets received a polymeric infant formula diet throughout the study period and were sacrificed at two weeks post-surgery.Clinical outcomes including weight, stool consistency and presence of stool fat globules were monitored.High throughput DNA sequencing of colonic content was used to detect surgery-relateddisturbances in microbial composition at phylum, family and genus level.Diversity and richness estimates were calculated for the control and minor surgery groups.As disturbances in the gut microbial community are linked to inflammation we compared the gene expression of key inflammatory cytokines(TNF, IL1 B, IL18, IL12, IL8, IL6 and IL10) in ileum, terminal ileum and colon mucosal extracts obtained from control and abdominal surgery groups at two weeks post-surgery.RESULTS: Changes in the relative abundance of bacterial species at family and genus level were confined to bacterial members of the Proteobacteria and Bacteroidetes phyla.Family level compositional shifts included a reduction in the relative abundance of Enterobacteriaceae(22.95 ± 5.27 vs 2.07 ± 0.72, P < 0.01), Bacteroidaceae(2.54 ± 0.56 vs 0.86 ± 0.43, P < 0.05) and Rhodospirillaceae(0.40 ± 0.14 vs 0.00 ± 0.00, P < 0.05) following transection surgery.Similarly, at the genus level, changes associated with transection surgery were restricted to members of the Proteobacteria and Bacteroidetes phyla and included decreased relative abundance of Enterobacteriaceae(29.20 ± 6.74 vs 2.88 ± 1.08, P < 0.01), Alistipes(4.82 ± 1.73 vs 0.18 ± 0.13, P < 0.05) and Thalassospira(0.53 ± 0.19 vs 0.00 ± 0.00, P < 0.05).Surgeryassociated microbial dysbiosis was accompanied by increased gene expression of markers of inflammation.Within the ileum IL6 expression was decreased(4.46 ± 1.60 vs 0.24 ± 0.06, P < 0.05) following transection surgery.In the terminal ileum, gene expression of TNF was decreased(1.51 ± 0.13 vs 0.80 ± 0.16, P < 0.01) and IL18(1.21 ± 0.18 vs 2.13 ± 0.24, P < 0.01), IL12(1.04 ± 0.16 vs 1.82 ± 0.32, P < 0.05) and IL10(1.04 ± 0.06 vs 1.43 ± 0.09, P < 0.01) gene expression increased following transection surgery.Within the colon, IL12(0.72 ± 0.13 vs 1.78 ± 0.28, P < 0.01) and IL10(0.98 ± 0.02 vs 1.95 ± 0.14, P < 0.01) gene expression were increased following transection surgery.CONCLUSION: This study suggests that minor abdominal surgery in infants, results in long-term alteration of the colonic microbial composition and persistent gastrointestinal inflammation. | Susan Lapthorne Julie E Bines Fiona Fouhy Nicole L Dellios Guineva Wilson Sarah L Thomas Michelle Scurr Catherine Stanton Paul D Cotter Prue M Pereira-Fantini | 2015 | World Journal of Gastroenterology2015，21，14： | 3 |
| 3 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 4 | catalase, a noval antigen for HP vaccination 显示文摘 | Suart L Kolesnikow tassia | 1997 | Infection and immunity1997，65，11： | 1 |
| 5 | The Fas-FADD death domain complex structure unravels signaling by receptor clustering显示文摘 | Fiona L Bouguslaw S Cristina P | | 0，，7232： | 1 |
| 6 | The effect of operational parameters on the photocatalytic degradation of humic acid显示文摘 | Fiona L Palmer Brian R Eggins Heather M Coleman | 2002 | Journal of Photochemistry & Photobiology, A: Chemistry2002，，1： | 1 |
| 7 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 8 | Effect of low doses of ionizing radiation on cells cultured from the Hematopoietic tissue of the dubin bay Prawn, Nephrops norvegicus 显示文摘 | Carmel M Fiona L Alba M | 2001 | Radiation Research2001，156，： | 1 |
| 9 | Endophytic bacteria and their potential applications显示文摘 | Cindy L Jaco V Fiona P | 2002 | Crit Rev Plant Sci2002，21，： | 1 |
| 10 | Human inhibitor of apoptosis proteins:why xiap is the black sheep of the family显示文摘 | Brendan P Eckelman Guy S Salvesen Fiona L Scott | | 0，，： | 1 |
| 11 | Illman: A longitudinal study of the New York Times Science Times Section 显示文摘 | Fiona Clark and Deborah L | 2006 | Science Review2006，27，： | 1 |
| 12 | Synthesis of inorganic nanophase material in supramolecular protein cages显示文摘 | Fiona C M Vanessa J W Duncan L N | 1991 | Nature1991，，349： | 1 |
| 13 | The effect of operational parameters on the photocatalytic degradation of humic acid 显示文摘 | Palmer Fiona L Eggins Brian R Coleman Heather M | 2002 | Journal of Photochemistry and Photobiology A: Chemistry2002，148，13： | 1 |
| 14 | Amorphous calcium carbonate is stabilized in confinement 显示文摘 | Christopher S J Sophie L F Fiona M C Hugo C K | 2010 | Advanced Functional Materials2010，20，13： | 1 |
| 15 | Endophytic bacteria and their potential application显示文摘 | Cindy L Vangronsveld J Fiona P | 2002 | Critical Reviews in Plant Sciences2002，21，6： | 1 |
| 16 | Wave-driven zonal flow vacillation in the Southern Hemisphere 显示文摘 | Hartmann D L Fiona L | 1998 | Journal of the Atmospheric Sciences1998，55，： | 1 |
| 17 | Consumptive water use and stomatal conductance of Atriplex lentiformis irrigated with industrial brine in a desert irrigation district 显示文摘 | Fiona L Jordan Martin Yoklie Yiyomi Morino | 2009 | Agricul For Meteor2009，149，5： | 1 |
| 18 | Endophytic bacteria and their potential applications 显示文摘 | Cindy L Jaeo V Fiona P | 2002 | Critical Reviews in Plant Sciences2002，21，6： | 1 |
| 19 | Endophytic bacteria and their potential applications显示文摘 | Cindy L Jaco V Fiona P | 2002 | Critical Reviews in Plant Science2002，21，6： | 1 |
| 20 | Endophytic bacteria and their potential applications显示文摘 | Cindy L Jaco V Fiona P | 2002 | Critical Reviews in Plant Sciences2002，21，6： | 1 |
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