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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Early clinical worsening in patients with TIA or minor stroke: The Austrian Stroke Unit Registry显示文摘 | J Ferrari M Knoflach S Kiechl J Willeit S Schnabl L Seyfang W Lang | 2010 | Neurology2010，，2： | 2 |
| 3 | Combined treatment with a β-blocker and intermittent PTH improves bone mass and mieroarehitecture in ovariectomized mice 显示文摘 | Pierroz D D Bouxsein M L Rizzoli R Ferrari S L | 2006 | Bone2006，39，： | 1 |
| 4 | IgG subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpura 显示文摘 | Ferrari S Mudde GC Rieger M | 2009 | J Thromb Haemost2009，7，： | 1 |
| 5 | IP-tO in autoimmune thyroiditis 显示文摘 | RUFFILLI I FERRARI S M COLACI M | 2014 | Horm Metab Res2014，46，9： | 1 |
| 6 | Neoadjuvant chemothera- py with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the ex- tremity: a joint study by the Italian and Scandinavian Sarcoma Groups 显示文摘 | Ferrari S Smeland S Mercuri M | 2005 | J Clin Oncol2005，23，34： | 1 |
| 7 | Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial显示文摘 | Benjamin M Scirica Marc P Bonaca Eugene Braunwald Gaetano M De Ferrari Daniel Isaza Basil S Lewis Felix Mehrhof Piera A Merlini Sabina A Murphy Marc S Sabatine Michal Tendera Frans Van de Werf Robert Wilcox David A Morrow | 2012 | The Lancet . 2012 (9850)2012，，9850： | 1 |
| 8 | IgG subclass distri-bution of anti- ADAMTS13 antibodies in patients with acpuired thrombotic thrombocytopenic purpura 显示文摘 | Ferrari S Mudde GC Rieger M | 2009 | J Thromb Haemost2009，7，10： | 1 |
| 9 | Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG显示文摘 | Nguyen L Walburger A Houben E Koul A Muller S Morbitzer M Klebl B Ferrari G Pieters J | 2005 | J Bacteriol2005，187，16： | 1 |
| 10 | Recombinant human interleukin-11 (neumega, rhIL11) reduces thrombocytopenia in breast cancer patients receiving tandem autolous circulating progenitor cell transportation 显示文摘 | Ferrari S Danova M Porta C | 2002 | Ann Hematol2002，81，6： | 1 |
| 11 | Contribution of CgPDRI - regulated genes in enhanced virulence of azole - resistant Candida glabrata 显示文摘 | Ferrari S Sanguinetti M Torelli R | 2011 | PLoS One2011，6，17： | 1 |
| 12 | Different molecular behavior of CD40 mutants causing hyper-IgM syndrome显示文摘 | Lanzi G Ferrari S Vihinen M | | 0，，26： | 1 |
| 13 | Leptin inhibits steroid biosynthesis by human granulose-lutein cells 显示文摘 | Barreca A Mastorakos G Furlini M Vottero A Ferrari B Chrousos GP Bernasconi S | 2001 | Horm Metab Res2001，33，6： | 1 |
| 14 | Porcine sclera as a model of human sclera for in vitro transport experiments:histology,SEM,and comparative permeability显示文摘 | Nicoli S Ferrari G Quarta M | 2009 | Mol Vis2009，15，： | 1 |
| 15 | Prognostic value of P-glycoproteinin high-grade osteosarcoma显示文摘 | Serra M Picci P Ferrari S | 2007 | J ClinOncol2007，25，30： | 1 |
| 16 | New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation显示文摘 | Songia S Gnocchi P Ferrari M Fornasiero C D'Alessio R | 1999 | J Immunol1999，162，12： | 1 |
| 17 | Arabidopsis polygalacturonase-inhibiting proteins ( PGIP ) areregulated by diVerent signal transduction pathways during fungalinfection 显示文摘 | Ferrari S Vairo D Ausubel F M Cervone F De Lorenzo G | 2003 | Plant Cell2003，15，： | 1 |
| 18 | Endothelin-1 and 5-fluoroura- cil-induced cardiotoxicity显示文摘 | Porta C Moroni M Ferrari S | 1998 | Neoplasma1998，45，2： | 1 |
| 19 | Induction of systemic resistance against Plasmopara viticola in grapevine by Trichoderma harzianum T39 andbenzothiadiazole显示文摘 | Perazzolli M Dagostin S Ferrari A | 2008 | Biological Control2008，47，： | 1 |
| 20 | Template-impinted nanostructured swfaces for protein recognition 显示文摘 | Shi H Q Tsai W B Garrison M D Ferrari S Ratner B D | 1999 | Nature1999，398，6728： | 1 |
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