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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Early clinical worsening in patients with TIA or minor stroke: The Austrian Stroke Unit Registry显示文摘 | J Ferrari M Knoflach S Kiechl J Willeit S Schnabl L Seyfang W Lang | 2010 | Neurology2010，，2： | 2 |
| 3 | Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG显示文摘 | Nguyen L Walburger A Houben E Koul A Muller S Morbitzer M Klebl B Ferrari G Pieters J | 2005 | J Bacteriol2005，187，16： | 1 |
| 4 | Risk factors for complications after performance of ERCP显示文摘 | Vandervoort J Soetikno R M Tham T C Wong R C Ferrari A P Jr Montes H | 2002 | Gastrointest Endosc2002，56，： | 1 |
| 5 | Microcolony cultivation on a soil substrate membrane system selects for previously uncultured soil bacteria显示文摘 | Belinda C Ferrari Binnerup S J Gillings M | 2005 | Applied and Environmental Microbiology2005，71，12： | 1 |
| 6 | Effects of bacterial secondary symbionts on host plant use in pea aphids 显示文摘 | McLean AHC van Asch M Ferrari J | 2010 | Proceedings of the Royal Society B: Biological Sciences2010，，： | 1 |
| 7 | Role of melanin in appressorium function 显示文摘 | Howard R J Ferrari M A | 1989 | Experimental Mycology1989，13，： | 1 |
| 8 | Influence of root signals resulting from soil dehydration and high soil strength on grow of crop plants显示文摘 | Ludlow M M Sommer K L Flower D J Ferraris R So H B | 1989 | Current Topics in Plant Biochemistry and Physiology1989，8，： | 1 |
| 9 | Effect of salinity on the osmotic, chloride, total protein and calcium concentrations in the hemolymph of the prawn Penaeus monodon 显示文摘 | Ferraris R P Parado-Estepa F D Ladfa J M | 1986 | Comparative Biochemistry and Physiology Part B1986，83，70： | 1 |
| 10 | Microcolony cultivation on a soil substrate membrane system selects for previously uncultured soil bacteria显示文摘 | FERRARI B C BINNERUP S J GILLINGS M | 2005 | Appl Environ Microbiol2005，71，12： | 1 |
| 11 | Activation of mieroglia by amyloid beta requires P2X7 receptor expression显示文摘 | Sauz J M Chiozzi P Ferrari D | 2009 | J Immunol2009，182，7： | 1 |
| 12 | An integer-based score to predict functional outcome in acute ischemic stroke: the ASTRAL score显示文摘 | Ntaios G Faouzi M Ferrari J | 2012 | Neurology2012，78，24： | 1 |
| 13 | Impact of immune escape mutations on HIV-1fitness in the context of the cognate transmitted/founder genome显示文摘 | Song H Pavlicek J W Cai F Bhattacharya T Li H Iyer S S Bar K J Decker J M Goonetilleke N Liu M K Berg A Hora B Drinker M S Eudailey J Pickeral J Moody M A Ferrari G McMichael A Perelson A S Shaw G M Hahn B H Haynes B F Gao F | 2012 | Retrovirology2012，9，： | 1 |
| 14 | Defect and disorder reduction by annealing in hydrogenated tetrahedral amorphous carbon显示文摘 | Conway N M Ferrari A C Flewitt A J et al | 2000 | Diamond and Related Materials2000，9，： | 1 |
| 15 | Effect of Stage 0 Sporulation Mutations on Subtilisin Expression显示文摘 | Ferrari E Howard S M H Hoch J A | 1986 | J Bacteriol1986，166，： | 1 |
| 16 | Electrospun mesoporous metal oxide fibers显示文摘 | Macias M Chacko A Ferraris J P | 2005 | Microporous and Mesoporous Materials2005，86，13： | 1 |
| 17 | Decreases in the expression of CGRP and galanin mRNA in central and peripheral neurons related to the control of blood pressure following experimental hypertension in rats显示文摘 | Coelho E F Ferrari M F Maximino J R | 2004 | Brain Res Bull2004，64，1： | 1 |
| 18 | Influence of platform switch-ing on crestal bone changes at non-submerged titanium im-plants: a histomorphometrical study in dogs 显示文摘 | Becker J Ferrari D Herten M | 2007 | J Clin Periodon-tol2007，34，： | 1 |
| 19 | Early clinical worsening in patients with TIA or minor stroke显示文摘 | Ferrari J Knoflach M Kiechl S | 2010 | Neurology2010，74，： | 1 |
| 20 | Preparation and electrochemical evaluation of poly(3-phenylthiophene) derivatives: potential materials for electrochemical capacitors 显示文摘 | Ferraris J P Eissa M M Brotherston I D | 1998 | J Electroanal Chem1998，459，1： | 1 |
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