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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Effect of two etching times on the sealing ability of Clearfil Liner Bond 2 in Class V restorations 显示文摘 | Ferrari M Mannocci F Vichi A | 1997 | Am J Dent1997，10，： | 1 |
| 3 | Surface roughness analysis of fiber post conditioning processes 显示文摘 | Mazzitelli C Ferrari M Toledano M Osorio E Monticelli F Osorio R | 2008 | J Dent Res2008，87，2： | 1 |
| 4 | A web-based distributed virtual educational laboratory显示文摘 | Benetazzo L Bertocco M Ferraris F | 2000 | IEEE Transaction on Instrumentation and Measurement2000，49，2： | 1 |
| 5 | Variability of interactions between neuroendocrine and immunological functions in physiological aging and dementia of the Alzheimer's type显示文摘 | Ferrari E Fioravanti M Magri F | 2000 | Ann N Y Acad Sci2000，917，： | 1 |
| 6 | Liquid-phase hot-pressing and WC-partide reinforcement of SiC-Si composites显示文摘 | Zhang B-R Marino F Ferraris M | 1994 | Journal of the European Ceramic Society1994，14，： | 1 |
| 7 | Study of the microstructure of o/w creams with thermal and theological methods 显示文摘 | K6nya M Sorrenti M Ferrari F | 2003 | J Therm Anal Calorim2003，73，2： | 1 |
| 8 | Multilayer coating with self-sealing properties forcarbon-carbon composites显示文摘 | SMEACETTO F FERRARIS M SALVO M | 2003 | Carbon2003，41，11： | 1 |
| 9 | Dissolution enhancement of a insoluble drug by mixture with a super-disintegrant:optimization with a simple lattice design显示文摘 | Ferrari F Bertoni M Bonferoni CM | 1996 | Pharm Dev Technol1996，1，2： | 1 |
| 10 | Kinetic mechanism and mierostruerure during the formation of Si3N4 matrix in Si3N4 MoSi2 composites显示文摘 | Beruto D T Ferrari A Giordani M Marino F | 2003 | Materials Science and Engineering2003，，355： | 1 |
| 11 | Multilayer coating with self healing properties for carbon carbon composites显示文摘 | Smeacetto F Ferraris M Salvo M | | 0，，11： | 1 |
| 12 | Clinical evaluation of fiber-reinforced epoxy resin posts and cast post and cores 显示文摘 | Ferrari M Vichi A Garcia- Godoy F | 2000 | Am J Dent2000，13，2： | 1 |
| 13 | Arabidopsis polygalacturonase-inhibiting proteins ( PGIP ) areregulated by diVerent signal transduction pathways during fungalinfection 显示文摘 | Ferrari S Vairo D Ausubel F M Cervone F De Lorenzo G | 2003 | Plant Cell2003，15，： | 1 |
| 14 | Mobile thrombi of the right heart in pulmonary embolism显示文摘 | Ferrari E Benhamou M Berthier F | 2005 | Chest2005，127，6： | 1 |
| 15 | Microwave-hydrothermal Synthesis of Nanocrystalline Zirconia Powders显示文摘 | Bondioli F Ferrari A M Leonelli C | 2001 | Journal of the American Ceramic Society2001，84，11： | 1 |
| 16 | Polygalaeturonase-inhihiting protein 2 of Phaseolus vulgaris inhibits BcPG1, a polygalacturonase of Botrytis cinerea important for pathogenicity, and protects transgenic plants from infection 显示文摘 | Manfredini C Sicilia F Ferrari S Pontiggia D Salvi G Caprai C Lorito M De Lorenzo G | 2006 | Physiol Mol Plant Pathol2006，67，： | 1 |
| 17 | Development of Oral Controlled-Release Tablet Formula tions Based on Diltiazem-Carrageenan Complex显示文摘 | Bonferoni M C Rossi S Ferrari F | 2004 | Pharm Develop Technol2004，9，2： | 1 |
| 18 | Retrospective study of the clinical performance of fiber posts显示文摘 | Ferrari M Vichi A Mannocci F | 2000 | Am J Dent2000，13，： | 1 |
| 19 | Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline 显示文摘 | HOLICK M F BINKLEY N C BISCHOFF - FERRARI H A | 2011 | J Clin Endocrinol Metab2011，96，7： | 1 |
| 20 | Immunization against bovine rotaviral infection 显示文摘 | Castrucci G Frigeri F Ferrari M | 1989 | Eur J Epidemiol1989，5，3： | 1 |
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