|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Protein kinase G from pathogenic mycobacteria promotes survival within macrophages显示文摘 | Walburger A Koul A Ferrari G Nguyen L PrescianottoBaschong C Huygen K Klebl B Thompson C Bacher G Pieters J | 2004 | Science2004，304，5678： | 1 |
| 3 | Numerical simulation of flow interference be-tween two circular cylinders in tandem and side-by-side arrangements显示文摘 | Meneghini J R Saltara F Siqueira C L R Ferrari J A | 2001 | Journal of Fluids and Struc-tures2001，15，2： | 1 |
| 4 | Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG显示文摘 | Nguyen L Walburger A Houben E Koul A Muller S Morbitzer M Klebl B Ferrari G Pieters J | 2005 | J Bacteriol2005，187，16： | 1 |
| 5 | Postmortem analysis of formic acid disposition in acute methanol intoxication显示文摘 | FERRARI L A ARADO M G NARDO C A | 2003 | Forensic Sci Int2003，133，12： | 1 |
| 6 | Crystallization of (Na2O-MgO)-CaO-Al2O3-SiO2 systems formulated from waste products显示文摘 | BARBIERI L FERRARI A M LANCELLOTTI I | 2000 | J Am Ceram Soc2000，83，10： | 1 |
| 7 | Influence of Ceramic and Cement Thickness on the Masking of Various Types of Opaque Post显示文摘 | Vichi A Ferrari M Davidson C L | 2000 | J Prosthet Dent2000，83，： | 1 |
| 8 | Biomarkers of a native fish species( Cnesterodon decemmaculatus) application to the water toxicity assessment of a peri - urban polluted river of Argentina显示文摘 | de la Torte F R Ferrari L Salibian A | 2005 | Chemosphere2005，59，4： | 1 |
| 9 | Uniprocessor scheduling under precedence constraints for embedded systems design显示文摘 | Mangeruca L Baleani M Ferrari A | 2007 | ACM Transactions on Embedded Computing Systems2007，7，1： | 1 |
| 10 | Calcium en riehed foods and bone mass growth in prepubertal girls: A randomized, double-blind, placebo-controlled trial 显示文摘 | Bonjour J P Carrie A L Ferrari S | 1997 | J Clin Invest1997，99，6： | 1 |
| 11 | Leptin inhibits steroid biosynthesis by human granulose-lutein cells 显示文摘 | Barreca A Mastorakos G Furlini M Vottero A Ferrari B Chrousos GP Bernasconi S | 2001 | Horm Metab Res2001，33，6： | 1 |
| 12 | Candidate blanket concept for a European fusion power plant study显示文摘 | Giancarli L Ferrari M Futterer M A | 2000 | Fusion Engineering and Design2000，4950，： | 1 |
| 13 | Eosinophils within the healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide显示文摘 | Metwali A Blum AM Ferraris L | 1994 | J Neuroimmunol1994，52，： | 1 |
| 14 | Candidate blanket concepts for a european fusion power plant study显示文摘 | GIANCARLI L FERRARI M FUTTEERER M A | | Fusion Engineering and Design0，4950，： | 1 |
| 15 | Gonadotropin-relea sing hormone antagonists increase follicular fluid insulin-like growth factor-Ⅰ and vascular endothelial growth factor during ovarian stimulation cycles显示文摘 | Ferrari B Pezzuto A Barusi L | 2006 | Gynecol Endocrinol2006，22，6： | 1 |
| 16 | Biomarkers of a native fish species (Cnesterodon decemmaculatus) application to the water toxicity assessment of a peri-urban polluted river of Argentina显示文摘 | DE LA TORRE F R FERRARI L SALIBIAN A | 2005 | Chemosphere2005，59，4： | 1 |
| 17 | Clean conditions for the determination of ultra-low levels of mercury in ice and snow samples显示文摘 | Ferrari C P Moreau A L Boutron C F | | 0，，： | 1 |
| 18 | Biomarkers Assessment in Juvenile Cyprinus crapio Exposed to Waterborne Cadmium显示文摘 | DE LA TORRE F R SALIBIN A FERRARI L | 2000 | Environmental Pollution2000，109，： | 1 |
| 19 | 查看详情显示文摘 | Echtermeyer T J Brimell L Jasnos P K Lombardo A Gorbachev R V Grigorenko A N Geim A K Ferrari A C Novoselov K S | | 0，，： | 1 |
| 20 | Mieroeolie turbines in the built environment: Influence of the installation site on the potential energy yield显示文摘 | Balduzzi F Bianchini A Ferrari L | 2012 | RenewableEnergy2012，45，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员