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| 1 | Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement显示文摘 | Scott M. Grundy James I. Cleeman Stephen R. Daniels Karen A. Donato Robert H. Eckel Barry A. Franklin David J. Gordon Ronald M. Krauss Peter J. Savage Sidney C. Smith John A. Spertus Fernando Costa | 2005 | Circulation2005，，17： | 7 |
| 2 | Exercise training in the management of patients with resistant hypertension显示文摘Hypertension is a very prevalent risk factor for cardiovascular disease. The prevalence of resistant hypertension, i.e., uncontrolled hypertension with 3 or more antihypertensive agents including 1 diuretic, is between 5% and 30% in the hypertensive population. The causes of resistant hypertension are multifactorial and include behavioral and biological factors, such as nonadherence to pharmacological treatment. All current treatment guidelines highlight the positive role of physical exercise as a non-pharmacological tool in the treatment of hypertension. This paper draws attention to the possible role of physical exercise as an adjunct non-pharmacological tool in the management of resistant hypertension. A few studies have investigated it, employing different methodologies, and taken together they have shown promising results. In summary, the available evidence suggests that aerobic physical exercise could be a valuable addition to the optimal pharmacological treatment of patients with resistant hypertension. | Fernando Ribeiro Rui Costa José Mesquita-Bastos | 2015 | World Journal of Cardiology2015，7，2： | 6 |
| 3 | 代谢综合征的诊断和治疗——美国心脏协会/国立心肺血液研究所指南概要显示文摘 | Scott M. Grundy James I. Cleeman Stephen R. Daniels Karen A. Donato Robert H. Eckel Barry A.Franklin David J. Gordon Ronald M. Krauss Peter J. Savage Sidney C. Smith John A. Spertus Fernando Costa | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，4： | 5 |
| 4 | Radiofrequency combined with immunomodulation for hepatocellular carcinoma: State of the art and innovations显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this approach.To solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and immunotherapy.This article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA alone.This review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic. | Adriano Carneiro da Costa Mikael Sodergren Kumar Jayant Fernando Santa Cruz Duncan Spalding Madhava Pai Nagy Habib | 2020 | World Journal of Gastroenterology2020，26，17： | 5 |
| 5 | Lymphocyte subsets in alcoholic liver disease显示文摘AIM:To compare lymphocyte subsets between healthy controls and alcoholics with liver disease.METHODS:The patient cohort for this study included individuals who were suspected to have alcoholic liver disease(ALD) and who had undergone liver biopsy(for disease grading and staging,doubts about diagnosis,or concurrent liver disease;n = 56).Normal controls included patients who were admitted for elective cholecystectomy due to non-complicated gallstones(n = 27).Formalin-fixed,paraffin-embedded liver biopsy specimens were sectioned and stained with hematoxylin and eosin and Perls' Prussian blue.The non-alcoholic steatohepatitis score was used to assess markers of ALD.Lymphocyte population subsets were determined by flow cytometry.T lymphocytes were identified(CD3+),and then further subdivided into CD4+ or CD8+ populations.B lymphocytes(CD19+) and natural killer(NK) cell numbers were also measured.In addition to assessing lymphocyte subpopulation differences between ALD patients and controls,we also compared subsets of alcoholic patients without cirrhosis or abstinent cirrhotic patients to normal controls.RESULTS:The patient cohort primarily consisted of older men.Active alcoholism was present in 66.1%.Reported average daily alcohol intake was 164.9 g and the average lifetime cumulative intake was 2211.6 kg.Cirrhosis was present in 39.3% of the patients and 66.1% had significant fibrosis(perisinusoidal and portal/periportal fibrosis,bridging fibrosis,or cirrhosis) in their liver samples.The average Mayo end-stage liver disease score was 7.6.No hereditary hemochromatosis genotypes were found.ALD patients(n = 56) presented with significant lymphopenia(1.5 × 109/L ± 0.5 × 109/L vs 2.1 × 109/L ± 0.5 × 109/L,P < 0.0001),due to a decrease in all lymphocyte subpopulations,except for NK lymphocytes:CD3+(1013.0 ± 406.2/mm3 vs 1523.0 ± 364.6/mm3,P < 0.0001),CD4+(713.5 ± 284.7/mm3 vs 992.4 ± 274.7/mm3,P < 0.0001),CD8+(262.3 ± 140.4/mm3 vs 478.9 ± 164.6/mm3,P < 0.0001),and CD19+(120.6 ± 76.1/mm3 vs 264.6 ± 88.0/mm3,P < 0.0001).CD8+ lymphocytes suffered the greatest reduction,as evidenced by an increase in the CD4+/CD8+ ratio(3.1 ± 1.3 vs 2.3 ± 0.9,P = 0.013).This ratio was associated with the stage of fibrosis on liver biopsy(rs = 0.342,P = 0.01) and with Child-Pugh score(rs = 0.482,P = 0.02).The number of CD8+ lymphocytes also had a positive association with serum ferritin levels(rs = 0.345,P = 0.009).Considering only patients with active alcoholism but not cirrhosis(n = 27),we found similar reductions in total lymphocyte counts(1.8 × 109/L ± 0.3 × 109/L vs 2.1 × 109/L ± 0.5 × 109/L,P = 0.018),and in populations of CD3+(1164.7 ± 376.6/mm3 vs 1523.0 ± 364.6/mm3,P = 0.001),CD4+(759.8 ± 265.0/mm3 vs 992.4 ± 274.7/mm3,P = 0.003),CD8+(330.9 ± 156.3/mm3 vs 478.9 ± 164.6/mm3,P = 0.002),and CD19+(108.8 ± 64.2/mm3 vs 264.6 ± 88.0/mm3,P < 0.0001).In these patients,the CD4+/CD8+ ratio and the number of NK lymphocytes was not significantly different,compared to controls.Comparing patients with liver cirrhosis but without active alcohol consumption(n = 11),we also found significant lymphopenia(1.3 × 109/L ± 0.6 × 109/L vs 2.1 × 109/L ± 0.5 × 109/L,P < 0.0001) and decreases in populations of CD3+(945.5 ± 547.4/mm3 vs 1523.0 ± 364.6/mm3,P = 0.003),CD4+(745.2 ± 389.0/mm3 vs 992.4 ± 274.7/mm3,P = 0.032),CD8+(233.9 ± 120.0/mm3 vs 478.9 ± 164.6/mm3,P < 0.0001),and CD19+(150.8 ± 76.1/mm3 vs 264.6 ± 88.0/mm3,P = 0.001).The NK lymphocyte count was not significantly different,but,in this group,there was a significant increase in the CD4+/CD8+ ratio(3.5 ± 1.3 vs 2.3 ± 0.9,P = 0.01).CONCLUSION:All patient subsets presented with decreased lymphocyte counts,but only patients with advanced fibrosis presented with a significant increase in the CD4+/CD8+ ratio. | Luís Costa Matos Paulo Batista Nuno Monteiro Joo Ribeiro Maria A Cipriano Pedro Henriques Fernando Giro Armando Carvalho | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 6 | GO FAIR Brazil:A Challenge for Brazilian Data Science显示文摘The FAIR principles,an acronym for Findable,Accessible,Interoperable and Reusable,are recognised worldwide as key elements for good practice in all data management processes.To understand how the Brazilian scientific community is adhering to these principles,this article reports Brazilian adherence to the GO FAIR initiative through the creation of the GO FAIR Brazil Office and the manner in which they create their implementation networks.To contextualise this understanding,we provide a brief presentation of open data policies in Brazilian research and government,and finally,we describe a model that has been adopted for the GO FAIR Brazil implementation networks.The Brazilian Institute of Information in Science and Technology is responsible for the GO FAIR Brazil Office,which operates in all fields of knowledge and supports thematic implementation networks.Today,GO FAIR Brazil-Health is the first active implementation network in operation,which works in all health domains,serving as a model for other fields like agriculture,nuclear energy,and digital humanities,which are in the process of adherence negotiation.This report demonstrates the strong interest and effort from the Brazilian scientific communities in implementing the FAIR principles in their research data management practices. | Luana Sales Patricia Henning Viviane Veiga Maira Murrieta Costa Luis Fernando Sayao Luiz Olavo Bonino da Silva Santos Luis Ferreira Pires | 2020 | Data Intelligence2020，2，1： | 3 |
| 7 | Urgent tracheostomy: four-year experience in a tertiary hospital显示文摘BACKGROUND: Urgent airway management is one of the most important responsibilities of otolaryngologists, often requiring a multidisciplinary approach. Urgent surgical airway intervention is indicated when an acute airway obstruction occurs or there are intubation difficulties. In these situations, surgical tracheostomy becomes extremely important.METHODS: We retrospectively studied the patients who underwent surgical tracheostomy from 2011 to 2014 by an otolaryngologist team at the operating theater of the emergency department of a tertiary hospital. Indications, complications and clinical evolution of the patients were reviewed.RESULTS: The study included 56 patients(44 men and 12 women) with a median age of 55 years. The procedure was performed under local anesthesia in 21.4% of the patients. Two(3.6%) patients were subjected to conversion from cricothyrostomy to tracheostomy. Head and neck neoplasm was indicated in 44.6% of the patients, deep neck infection in 19.6%, and bilateral vocal fold paralysis in 10.7%. Stridor was the most frequent signal(51.8%). Of the 56 patients, 15 were transferred to another hospital. Among the other 41 patients, 21 were decannulated(average time: 4 months), and none of them were cancer patients. Complications occurred in 5(12.2%) patients: hemorrhage in 3, surgical wound infection in 1, and cervico-thoracic subcutaneous emphysema in 1. No death was related to the procedure.CONCLUSION: Urgent tracheostomy is a life-saving procedure for patients with acute airway obstruction or with diffi cult intubation. It is a safe and effective procedure, with a low complication rate, and should be performed before the patient's clinical status turns into a surgical emergency situation. | Liliana Costa Ricardo Matos Sara Julio Fernando Vales Margarida Santos | 2016 | World Journal of Emergency Medicine2016，7，3： | 3 |
| 8 | The influence of transforming growth factor‐α, cyclooxygenase‐2, matrix metalloproteinase (MMP)‐7, MMP‐9 and CXCR4 proteins involved in epithelial–mesenchymal transition on overall survival of patients with gastric cancer显示文摘 | Marcello Ferretti Fanelli Ludmilla T Domingos Chinen Maria Dirlei Begnami Wilson Luis Costa José Humberto T Fregnami Fernando A Soares André Luis Montagnini | 2012 | Histopathology2012，，2： | 2 |
| 9 | Clinical prognostic factors for disabling Crohn's disease: A systematic review and meta-analysis显示文摘AIM: To identify demographic and clinical factors asso-ciated with disabling Crohn's disease (CD). METHODS: A systematic review and meta-analysisof observational studies, focusing on the factors that can predict the prognosis of different outcomes of CD was undertaken. PubMed, ISI Web of Knowledge and Scopus were searched to identify studies investigat-ing the above mentioned factors in adult patients with CD. Studies were eligible for inclusion if they describe prognostic factors in CD, with inclusion and exclusion criteria defined as follows. Studies with adult patients and CD, written in English and studying association between clinical factors and at least one prognosis out-come were included. Meta-analysis of effects was un-dertaken for the disabling disease outcome, using odds ratio (OR) to assess the effect of the different factors in the outcome. The statistical method used was Mantel-Haenszel for fixed effects. The 16-item quality assess-ment tool (QATSDD) was used to assess the quality of the studies (range: 0-42). RESULTS: Of the 913 papers initially selected, sixty studies were reviewed and three were included in the systematic review and meta-analysis. The global QA-TSDD scores of papers were 18, 21 and 22. Of a total of 1961 patients enrolled, 1332 (78%) were classified with disabling disease five years after diagnosis. In two studies, age at diagnosis was a factor associated with disabling disease five years after diagnosis. Individu-als under 40 years old had a higher risk of developing disabling disease. In two studies, patients who were treated with corticosteroids on the first flare developed disabling disease five years after diagnosis. Further, perianal disease was found to be relevant in all of the studies at two and five years after diagnosis. Finally, one study showed localization as a factor associated with disabling disease five years after diagnosis, with L3 being a higher risk factor. This meta-analysis showed a significantly higher risk of developing disabling dis-ease at five years after initial diagnosis among patients younger than 40 years of age (OR=2.47, 95%CI: 1.74-3.51), with initial steroid treatment for first flare (OR=2.42, 95%CI: 1.87-3.11) and with perianal dis-ease (OR = 2.00, 95%CI: 1.41-2.85).CONCLUSION: Age at diagnosis, perianal disease, ini-tial use of steroids and localization seem to be indepen-dent prognostic factors of disabling disease. | Cláudia Camila Dias Pedro Pereira Rodrigues Altamiro da Costa Pereira Fernando Magro | 2013 | World Journal of Gastroenterology2013，19，24： | 2 |
| 10 | β -Hydoxy- β -methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner显示文摘 | érico Chagas Caperuto Ronaldo Vagner Tomatieli Alison Colquhoun Marília Cerqueira Leite Seelaender Luis Fernando Bicudo Pereira Costa Rosa | 2006 | Clinical Nutrition2006，，1： | 2 |
| 11 | Waterborne polyurethane/acrylate: Comparison of hybrid and blend systems显示文摘 | Pablo J. Peruzzo Pablo S. Anbinder Oscar R. Pardini Jorge Vega Carlos A. Costa Fernando Galembeck Javier I. Amalvy | 2011 | Progress in Organic Coatings2011，，3： | 2 |
| 12 | Spermatogenesis recovery in the mouse after iron injury显示文摘 | Maria de Lourdes Pereira Fernando Garcia e Costa | 2003 | Human & Experimental Toxicology2003，22，： | 1 |
| 13 | Sleep Apnea and Cardiovascular Disease显示文摘 | Virend K. Somers David P. White Raouf Amin William T. Abraham Fernando Costa Antonio Culebras Stephen Daniels John S. Floras Carl E. Hunt Lyle J. Olson Thomas G. Pickering Richard Russell Mary Woo Terry Young | 2008 | Journal of the American College of Cardiology2008，，8： | 1 |
| 14 | Mathematical model of a smoldering log显示文摘 | Fernando de Souza Costa David Sandberg | 2004 | Combustion and Flame2004，139，： | 1 |
| 15 | Electrochemical double layer at the interfaces of Hg/choline chloride based solvents显示文摘 | Renata Costa Marta Figueiredo Carlos M. Pereira Fernando Silva | 2010 | Electrochimica Acta2010，，28： | 1 |
| 16 | Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement显示文摘 | Scott M. Grundy James I. Cleeman Stephen R. Daniels Karen A. Donato Robert H. Eckel Barry A. Franklin David J. Gordon Ronald M. Krauss Peter J. Savage Sidney C. Smith John A. Spertus Fernando Costa | 2005 | Circulation2005，，17： | 1 |
| 17 | Extra-intestinal malignancies in inflammatory bowel disease: Results of the 3rd ECCO Pathogenesis Scientific Workshop (III)显示文摘 | Fernando Magro Laurent Peyrin-Biroulet Harry Sokol Xavier Aldeger Antonia Costa Peter D. Higgins Joel C. Joyce Konstantinos H. Kastanos Anthony Lopez Teresa Mas de Xaxars Elena Toader Laurent Beaugerie | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 18 | Contribution of major structural changes in myofibrils to rabbit meat tenderisation during ageing显示文摘 | José A Mestre Prates Fernando J.S Garcia e Costa António Mário R Ribeiro António A Dias Correia | 2002 | Meat Science2002，，1： | 1 |
| 19 | Wastewater reuse for fiber crops cultivation as a strategy to mitigate desertification显示文摘 | Bruno Barbosa Jorge Costa Ana Luisa Fernando Eleni G. Papazoglou | 2014 | Industrial Crops & Products2014，，： | 1 |
| 20 | Influence of Total Intravenous Anesthesia, Entropy and Laparoscopy on Oxidative Stress显示文摘 | Rogean Rodrigues Nunes Fernando Squeff Nora Danielle Maia Holanda Dumaresq Rute Maria Araújo Cavalcante Amanda Antunes Costa Lara Moreira Mendes Carneiro Julio Cesar Garcia de Alencar Flávia Pereira Fernandes Cardoso | 2012 | Brazilian Journal of Anesthesiology2012，，4： | 1 |
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