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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Relationships between oxygen availability and metabolic cost of breathing in Nile tilapia (Oreochronis niloticus):aquacultural consequences显示文摘 | Rantin F T | 1994 | Aquaculture1994，127，： | 1 |
| 3 | Tribological properties of self-lubricating TiSiVN coatings at room temperature 显示文摘 | Fernandes F Polcar T Cavaleiro A | 2014 | Surface ~y-Coatings Technology2014，267，： | 1 |
| 4 | The impact of the internet upon bank marketing显示文摘 | Proenca J F Silva M M Fernandes T | 2010 | Journal of Financial Services Market- ing2010，，2： | 1 |
| 5 | Isola- tion and characterization of a Pseudomonas aeruginosa from a virgin Brazilian Amazon region with potential to degrade a- trazine显示文摘 | Fernandes A F T da Silva M B P Martins V V | 2014 | Environmental Science and Pollution Research2014，21，13： | 1 |
| 6 | Influence of different proteolytic strains of Streptococcus thermophilus in co-culture with Lactobacillus delbrueckii subsp, bulgaricus on the metabolite profile of set-yoghurt 显示文摘 | Settachaimongkon S Nout M J R Fernandes E C A Hettinga K A Vervoort J M van Hooijdonk T C M Zwietering M H Smid E J van Valenberg H J F | 2014 | International Journal of Food Microbiology2014，177，： | 1 |
| 7 | Relationships between oxygen availability and metabolic cost of breathing in Nile tilapia ( Oreochromis niloticus ) : aquacultural consequences 显示文摘 | FERNANDES M N RANTIN F T | 1994 | Aquaculture1994，127，： | 1 |
| 8 | Interspe- cies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles 显示文摘 | Gaiser B K Fernandes T F Jepson M A | 2012 | Environmental Toxicolo- gy and Chemistry2012，31，1： | 1 |
| 9 | Time-dependent effects of training on cardiovascular control in sponta- neously hypertensive rats: role for brain oxidative stress and inflammation and baroreflex sensitivity显示文摘 | Masson G S Costa T S Yshii L Fernandes D C Soares P P Laurindo F R | 2014 | PLoS One2014，9，94： | 1 |
| 10 | Anti-corrosion performance of new silane coating for corrosion protection of AZ31 magnesium alloy in Hank's solution 显示文摘 | ZOMORODIAN A BRUSCIOTTI F FERNANDES A CARMEZIM M J MOURAE SILVA T FERNANDES J C S MONTEMOR M F | 2012 | Surface and Coatings Technology2012，206，： | 1 |
| 11 | Microglia and inflammation: conspiracy, controversy or control 显示文摘 | Fernandes A Miller-Fleming L Pais T F | 2014 | Cell Mol Life Sci2014，7，20： | 1 |
| 12 | Evaluation of the Representativeness of Networks of Sites for the Global Validation and Intercomparison of Land Biophysical Products: Proposition of the CEOS-BELMANI显示文摘 | Baret F Morissette J T Fernandes R A | 2006 | IEEE Transactions on Geoseienee and Remote Sensing2006，44，7： | 1 |
| 13 | Self-assembly in biosilieification and biotemplated silica materials显示文摘 | Fernandes F Coradin T Aim C | 2014 | Nanomaterials2014，4，3： | 1 |
| 14 | Inter-Cell Interference in Noncooperative TDD Large Scale Antenna Systems 显示文摘 | Fernandes F Ashikhmin A Marzetta T L | 2013 | IEEE Journal on Selected Areas in Communications2013，31，2： | 1 |
| 15 | Interesterification of lard and Soyben Oil Blends Catalyzed by Immobilized Lipase in a Continuous Packed Bed Reactor 显示文摘 | Silva R C D De Martini Soares F A S Fernandes T G | 2001 | Journal of the American Oil Chemists'' Society2001，88，12： | 1 |
| 16 | Cold-induced repres- sion of the rice anther-specific cell wall invertase gene OSINV4 is correlated with sucrose accumulation and pollen sterility 显示文摘 | Oliver S N Van Dongen J T Alfred S C Mamun E Zhao X Saini H S Fernandes S F Blanchard C L Sutton B Gelgenberger P Dennis E Dolferus R | 2005 | Plant Cell &Environment2005，28，： | 1 |
| 17 | Effect of spray Escherichia coli vaccine on the immunity of poultry显示文摘 | FERNANDES FILHO T FVARO C INGBERMAN M | 2013 | Avian Dis2013，57，3： | 1 |
| 18 | Impacts of biodeposits form suspended mussel (Mytilus edulis L) culture on the surrounding surficial sediments 显示文摘 | CHAMBERLAIN J FERNANDES T F READ P | 2001 | Journal of Marine Science2001，58，： | 1 |
| 19 | The scientific principles underlying the monitoring of the environmental impacts of aquaculture 显示文摘 | FERNANDES T F ELEFTHERIOU A ACKEFORS H | 2001 | Journal of Applied Ichthyology2001，17，： | 1 |
| 20 | Growth of Si nanocrystals on alumina and integration in memory devices 显示文摘 | BARON T FERNANDES A DAMLENCOURT J F | 2003 | Applied Physics Letters2003，82，23： | 1 |
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