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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Characterization of Pore Systems in Seal Rocks Using Nitrogen Gas Adsorption Combined with Mercury Injection Capillary Pressure Techniques 显示文摘 | Schmitt M Fernandes C P da Cunha Neto J A B | 2013 | Marine and Petroleum Geology2013，39，1： | 1 |
| 3 | Effects of herbivory by Hyblaea puera ( Hyblaeidae : Lepidop- tera) on litter production in the mangrove on the coast of Brazi- lian Amazonia显示文摘 | FERNANDES M E B NASCIMENTO A A M CARVALHO M L | 2009 | Journal of Tropical Ecology2009，25，3： | 1 |
| 4 | Photochemical processes and the environmental impact of petroleum spills 显示文摘 | Nicodem D E Fernandes M C Z Guedes C L B | 1997 | Biogeochemistry1997，39，： | 1 |
| 5 | A Rac homolog functions downstream of Rasl to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans显示文摘 | Vallim M A Nichols C B Fernandes L | 2005 | Eukaryotic Cell2005，4，6： | 1 |
| 6 | Mathematical model coupling phase transformation and temperature evolution during quenching of steels显示文摘 | Fernandes F M B Denis S Simon A | 1984 | Materials Science and Technology1984，1，10： | 1 |
| 7 | Distributedcontrol to ensure proportional load sharing and improve voltageregulation in low voltage DC microgrids 显示文摘 | ANAND S FERNANDES B GfGUERRERO J M | 2013 | IEEE Transactionson Power Electronics2013，28，4： | 1 |
| 8 | Proteome reference map of the skin mucus of Atlantic cod (Gadus morhua ) revealing immune competent molecules显示文摘 | Rajan B Fernandes J M Christopher M A | 2011 | Fish and Shellfish Immunology2011，31，2： | 1 |
| 9 | Surgical removal of small petroclival meningiomas显示文摘 | Ramina R Neto M C Fernandes Y B | 2008 | Acta Neurochir (Wien)2008，150，4： | 1 |
| 10 | Gas chromatographic-mass spectrometric quantification of 4-(5- )- methylimidazole in roasted coffee after ion-pair extraction 显示文摘 | S Casal J O Fernandes M B P P Oliveira | 2002 | Journal of Chromatography A2002，976，： | 1 |
| 11 | Isola- tion and characterization of a Pseudomonas aeruginosa from a virgin Brazilian Amazon region with potential to degrade a- trazine显示文摘 | Fernandes A F T da Silva M B P Martins V V | 2014 | Environmental Science and Pollution Research2014，21，13： | 1 |
| 12 | Characterization and kinetic compensation effect of corn biodiesel显示文摘 | DANTAS M B ALMEIDA A A F CONCEICAO M M FERNANDES V J Jr SANTOS I M G SILVA F C SOLEDADE L F B SOUZA A G | 2007 | J Therm Anal Calorim2007，87，3： | 1 |
| 13 | Mathematical model coupling phased transformation and temperature evolution dur- ing quenching of steels 显示文摘 | Fernandes F M B Denis S Simon A | 1985 | Materials Science and Technolo- gy1985，1，10： | 1 |
| 14 | Fast analysis of multiple pesticide residues in apple juice using dispersive liquid -liquid microextraction and multidimensional gas chromatography-mass spectrometry显示文摘 | Cunha S C Fernandes J O Oliveira M B | 2009 | Journal of Chromatography A2009，1216，51： | 1 |
| 15 | Polyaromatic hydrocarbon (PAH)distributions in the Senine River and its estuary显示文摘 | FERNANDES M B SICRE M A BOIREAU A | 1997 | Marine Pollution Bulletin1997，34，11： | 1 |
| 16 | Pro- teome reference map of the skin mucus of Atlantic cod (Gadus morhua ) revealing immune competent mole- cules显示文摘 | Rajan B Fernandes J M Caipang C M | 2011 | Fish g> Shellfish Immunology2011，31，22： | 1 |
| 17 | Bioconcentration of triclosan and methyl-triclosan in marine mussels(Mytilus gallopro- vincialis) under laboratory conditions and inmetropolitan waters of Gulf St Vincent, South Australia显示文摘 | Kookana R S ShareefA Fernandes M B | 2013 | Marine Pollution Bulletin2013，74，1： | 1 |
| 18 | Mathematical Model Coupling Phase Transformation and Temperature Evolution During Quenching of Steels显示文摘 | Fernandes F M B Denis S Simon A | 1985 | Materials Science and Technology1985，1，10： | 1 |
| 19 | Characterization of pore systems in seal rocks using Nitrogen Gas Adsorption combined with Mercury Injection Capillary Pressure techniques显示文摘 | SCHMITT M FERNANDES C P JOSE A B | 2013 | Marine and Petroleum Geology2013，39，1： | 1 |
| 20 | Electrophysiological responses of female and male Hypsipyla grandella (Zeller) to Swietenia macrophylla essential oils显示文摘 | Soares M G Batista-Pereira L G Fernandes J B | 2003 | Joumal of Chemical Ecology2003，29，9： | 1 |
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