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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 3 | Prepara- tion and characterization of foams from sheet glass and fly ash using carbonates as foaming agents 显示文摘 | Fernandes H R Tulyaganov D U Ferreira J M F | 2009 | Ceram Int2009，35，1： | 1 |
| 4 | Environmental friendly management of CRT glass by foaming with waste egg shells, calcite or dolomite 显示文摘 | Fernandes H R Ferreira D D Andreola F | 2014 | Ceramics International2014，40，13： | 1 |
| 5 | High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism显示文摘 | Fernandes R Girao H Pereira P | 2004 | J Biol Chem2004，279，27： | 1 |
| 6 | Effects of Si speciation on the in vitro evaluation of bioactivity of glasses显示文摘 | OLIVERIRA J M CORREIA R N FERNANDES M H | 2002 | Biomaterials2002，23，2： | 1 |
| 7 | Dynamic modelling and simulation of a cogeneration system integrated with a salt recrystallization process 显示文摘 | Moita R D Matos H A Fernandes C | 2005 | Computers & Chemical Engineering2005，29，6： | 1 |
| 8 | Endogenous collagen influences differentiation of human multipotent mesenchymal stromal cells显示文摘 | Fernandes H Mentink A Bank R | | 0，，05： | 1 |
| 9 | Escherichia coli isolated from seafood:toxicity and plasmid profiles显示文摘 | Teophilo G N dos Fernandes V R H | 2002 | Int Microbiol2002，5，1： | 1 |
| 10 | Influence of different proteolytic strains of Streptococcus thermophilus in co-culture with Lactobacillus delbrueckii subsp, bulgaricus on the metabolite profile of set-yoghurt 显示文摘 | Settachaimongkon S Nout M J R Fernandes E C A Hettinga K A Vervoort J M van Hooijdonk T C M Zwietering M H Smid E J van Valenberg H J F | 2014 | International Journal of Food Microbiology2014，177，： | 1 |
| 11 | Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism显示文摘 | Santos S H Fernandes L R Mario E G | 2008 | Diabetes2008，57，： | 1 |
| 12 | Whole-cell biocatalysis in organic media显示文摘 | Fernandes P Pinheiro H M | 1998 | Enzyme & Microb technology1998，23，： | 1 |
| 13 | Effect of nutrient sources on yield, fruit quality and nutritional status of cucumber plants, cultivated in hydroponics 显示文摘 | Fernandes A A Martinez -H E P Oliveira -L R de et el | 2002 | Horticultura Brasileira2002，204，： | 1 |
| 14 | Latin American Applied Research 显示文摘 | Carvalho D A Bezerra-Rocha J H Fernandes N S Dasilva D R Martinez-Huitle C A | 2011 | 41 :1272011，41，： | 1 |
| 15 | Energy and protein requirements for maintenance and growth of Boer crossbred kids 显示文摘 | FERNANDES M H M R RESENDE K T TEDES- CHI L O | 2007 | J Anim Sci2007，85，4： | 1 |
| 16 | Design model for socket base connections adjusted from experimental results显示文摘 | R M Fernandes Canha A L H de Cresce El Debs M K EI Debs | 2007 | Structural Concrete2007，8，1： | 1 |
| 17 | Effects of polyunsaturated fatty acids (PUFAs) in the treat- ment of experimental chronic renal failure 显示文摘 | FERNANDES M B CALDAS H C MARTINS L R | 2012 | Int Urol Nephrol2012，44，5： | 1 |
| 18 | Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington' s disease显示文摘 | Fernandes H B Baimbridge K G Church J Hayden M R Raymond L A | 2007 | J Neurosci2007，27，13： | 1 |
| 19 | Hg(11) sensing based on {unctionalized carbon dots obtained by direct laser ablation显示文摘 | GONCALVES H M R JORGE P A S FERNANDES J R A | 2010 | Sensors and Actuators B Chemical2010，145，2： | 1 |
| 20 | Yield and fruit quality of industrial tomato under saline irrigation显示文摘 | Campos C A B Fernandes P D Gheyi H R | 2006 | Sci Agric2006，63，2： | 1 |
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