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| 1 | Construction of habitat suitability models(HSMs) for benthic macroinvertebrate and their applications to instream environmental flows:A case study in Xiangxi River of Three Gorges Reservior region,China显示文摘Based on a long-term ecological monitoring, the present study chose the most dominant benthic macroinvertebrate (Baetis spp.) as tar- get organisms in Xiangxi River, built the habitat suitability models (HSMs) for water depth, current velocity and substrate, respectively, which is the first aquatic organisms model for habitat suitability in the Chinese Mainland with a long-term consecutive in situ measurement. In order to protect the biointegrity and function of the river ecosystem, the theory system of instream environmental flow should be cat- egorized into three hierarchies, namely minimum required instream flow (hydrological level), minimum instream environmental flow (bio- species level), and optimum instream environmental flow (ecosystem level). These three hierarchies of instream environmental flow models were then constructed with the hydrological and weighted usable area (WUA) method. The results show that the minimum required instream flow of Xiangxi River calculated by the Tennant method (10% of the mean annual flow) was 0.615 m3 s 1; the minimum instream environmental flow accounted for 19.22% of the mean annual flow (namely 1.182 m3 s 1), which was the damaged river channel flow in the dry season; and 42.91% of the mean annual flow (namely 2.639 m3 s 1) should be viewed as the optimum instream environmental flow in order to protect the health of the river ecosystem, maintain the instream biodiversity, and reduce the impact of small hydropower stations nearby the Xiangxi River. We recommend that the hydrological and biological methods can help establish better instream environmental flow models and design best management practices for use in the small hydropower station project. | Fengqing Li Qinghua Cai Xiaocheng Fu Jiankang Liu | 2009 | Progress in Natural Science:Materials International2009，19，3： | 18 |
| 2 | Volatile Compounds in the Flowers of Freesia Parental Species and Hybrids显示文摘几个世纪,小苍兰属植物是在养花工业的最重要的庄稼之一。这里,从双小苍兰属植物的全部花收集的水空间样品测定一,三四倍体小苍兰属植物栽培变种的三四倍体小苍兰属植物栽培变种,和种间染种用气体被分析用色层法分离结合了质量选择察觉者。总共, 75 不同混合物被识别。混合物主要是萜烯,烃,白酒,脂肪酸酉旨和芳香的班混合物。在这些之中,沉香醇除了无味的白四倍体 F 从所有有香味的花被检测。混合一。在 F 之间的沉香醇的稳定的继承。混合一 and 他们的 F1 子孙被观察。基于现在的分析,在小苍兰属植物和沉香醇的芳香之间的关系被讨论。 | Yang Fu Xiang Gao Yiqun Xue Yuejun Hui Fengqing Chen Quanping Su Li Wang | 2007 | Journal of Integrative Plant Biology2007，49，12： | 4 |
| 3 | Therapeutic Characterization of ^(131)I-Labeled Humanized Anti-B7-H3 Antibodies for Radioimmunotherapy for Glioblastoma显示文摘B7 homolog 3(B7-H3)has attracted much attention in glioblastoma(GBM)radioimmunotherapy(RIT)due to its abnormally high expression on tumor cells.In this study,we report that two specific humanized anti-human B7-H3 antibodies(hu4G4 and hu4H12)derived from mouse anti-human B7-H3 antibodies that were generated by computer-aided design and exclusively recognize membrane expression of B7-H3 by human glioma cells,Hu4G4 and hu4H12 were radiolabeled with^(89)Zr for RIT antibody screening.Micro-positron emission tomography(PET)imaging,biodistribution and pharmacokinetic(PK)analyses of^(89)Zr-labeled antibodies were performed in U87-xenografted models.^(125)I labelling of the antibodies for single-photon emission computed tomography(SPECT)imaging was also used to investigate the biological behavior of the antibodies in vivo.Fu rthermore,the pharmacodynamic(PD)of the^(131)Ilabeled antibodies were evaluated in U87-xenografted mice and GL261 Red-FLuc-B7-H3 in situ glioma tumor models.Micro-PET imaging and biodistribution analysis with a gamma counter showed that^(89)Zr-deferoxamine(DFO)-hu4G4 had higher tumor targeting performance with lower liver uptake than^(89)Zr-DFO-(hu4H12,immunoglobulin G(IgG)).The biodistribution results of^(125)I-SPECT imaging were similar to those of^(89)Zr-PET imaging,though the biodistribution in long bone joints and the thyroid varied.The PD analysis results indicated that^(131)I-hu4G4 had an excellent therapeutic effect and high safety with no apparent toxicity.Interestingly,^(131)I-hu4G4 improved the tumor vasculature in tissues with higher expression of collagen typeⅣand platelet-derived growth factor receptorβ(PDGFR-β)compared with control treatment,as determined by immunofluorescence(IF),which contributed to inhibiting tumor growth.Taken together,our data indicate that hu4G4 exhibits good tumor targeting and specificity,achieves low nonspecific concentrations in normal tissues,and has acceptable PK characteristics.^(131)I-hu4G4 also exerts effective antitumor effects with an ideal safety profile.Therefore,we expect hu4G4 to be an excellent antibody for the development of GBM RIT. | Fengqing Fu Meng Zheng Shandong Zhao Yan Wang Minzhou Huang Hanqing Chen Ziyi Huang Kaijie Zhang Liyan Miao Xueguang Zhang | 2023 | Engineering2023，，11： | 0 |
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