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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | Temperature-induced Lifshitz transition in topological insulator candidate HfTe_5显示文摘The ongoing discoveries and studies of novel topological quantum materials have become an emergent and important field of condensed matter physics.Recently,HfTe_5 ignited renewed interest as a candidate of a novel topological material.The single-layer HfTe_5 is predicted to be a two-dimensional large band gap topological insulator and can be stacked into a bulk that may host a temperature-driven topological phase transition.Historically,HfTe_5 attracted considerable interest for its anomalous transport properties characterized by a peculiar resistivity peak accompanied by a sign reversal carrier type.The origin of the transport anomaly remains under a hot debate.Here we report the first high-resolution laser-based angle-resolved photoemission measurements on the temperature-dependent electronic structure in HfTe_5.Our results indicated that a temperature-induced Lifshitz transition occurs in HfTe_5,which provides a natural understanding on the origin of the transport anomaly in HfTe_5.In addition,our observations suggest that HfTe_5 is a weak topological insulator that is located at the phase boundary between weak and strong topological insulators at very low temperature. | Yan Zhang Chenlu Wang Guodong Liu Aiji Liang Lingxiao Zhao Jianwei Huang Qiang Gao Bing Shen Jing Liu Cheng Hu Wenjuan Zhao Genfu Chen Xiaowen Jia Li Yu Lin Zhao Shaolong He Fengfeng Zhang Shenjin Zhang Feng Yang Zhimin Wang Qinjun Peng Zuyan Xu Chuangtian Chen Xingjiang Zhou | 2017 | Science Bulletin2017，62，13： | 4 |
| 3 | Large-Scale Analyses of Glycosylation in Cellulases显示文摘Cellulases are important glycosyl hydrolases (GHs) that hydrolyze cellulose polymers into smaller oligosaccharides by breaking the cellulose β (1→4) bonds,and they are widely used to produce cellulosic ethanol from the plant biomass.N-linked and O-linked glycosylations were proposed to impact the catalytic efficiency,cellulose binding affinity and the stability of cellulases based on observations of individual cellulases.As far as we know,there has not been any systematic analysis of the distributions of N-linked and O-linked glycosylated residues in cellulases,mainly due to the limited annotations of the relevant functional domains and the glycosylated residues.We have computationally annotated the functional domains and glycosylated residues in cellulases,and conducted a systematic analysis of the distributions of the N-linked and O-linked glycosylated residues in these enzymes.Many N-linked glycosylated residues were known to be in the GH domains of cellulases,but they are there probably just by chance,since the GH domain usually occupies more than half of the sequence length of a cellulase.Our analysis indicates that the O-linked glycosylated residues are significantly enriched in the linker regions between the carbohydrate binding module (CBM) domains and GH domains of cellulases.Possible mechanisms are discussed. | Fengfeng Zhou Victor Olman Ying Xu | 2009 | Genomics, Proteomics & Bioinformatics2009，7，4： | 3 |
| 4 | Estimation of leaf area index from high resolution ZY-3 satellite imagery in a catchment dominated by Larix principis-rupprechtii,northern China显示文摘Leaf area index(LAI) is a key factor that determines a forest ecosystem's net primary production and energy exchange between the atmosphere and land surfaces.LAI can be measured in many ways, but there has been little research to compare LAI estimated by different methods. In this study, we compared the LAI results from two different approaches, i.e., the dimidiate pixel model(DPM) and an empirical statistic model(ESM) using ZY-3 high-accuracy satellite images validated by field data. We explored the relationship of LAI of Larix principis-rupprechtii Mayr plantations with topographic conditions. The results show that DPM improves the simulation of LAI(r = 0.86,RMSE = 0.57) compared with ESM(r = 0.62, RMSE =0.79). We further concluded that elevation and slope significantly affect the distribution of LAI. The maximum peak of LAI appeared at an aspect of east and southeast at an elevation of 1700–2000 m. Our results suggest that ZY-3 can satisfy the needs of quantitative monitoring of leaf area indices in small-scale catchment areas. DPM provides a simple and accurate method to obtain forest vegetation parameters in the case of non-ground measurement points. | Tian Wang Fengfeng Kang Hairong Han Xiaoqin Cheng Jiang Zhu Wensong Zhou | 2019 | Journal of Forestry Research2019，30，2： | 2 |
| 5 | A Recently Active Miniature Inverted-Repeat Transposable Element, Chunjie, Inserted Into an Operon Without Disturbing the Operon Structure in Geobacter uraniireducens Rf4显示文摘 | Chen Yong Zhou Fengfeng Li Guojun Xu Ying | 2008 | Genetics2008，，4： | 1 |
| 6 | Preliminary design and analysis of a cubic deployable support structure based on shape memory polymer composite显示文摘The deployable structures based on shape memory polymer com-posites(SMPCs)have been developed for its unique properties,such as high reliability,low-cost,lightweight,and self-deployment without complex mechanical devices compared with traditional deployable structures.In order to increase the inflatable structure system’s robustness and light the weight of it,a cubic deployable support structure based on SMPC is designed and analyzed pre-liminarily.The cubic deployable support structure based on SMPC consists of four dependent spatial cages,each spatial cage is composed of 12 three-longeron SMPC truss booms and end con-nections.The shape recovery of arc-shaped deployable laminates drive the three-longeron SMPC truss booms to unfold,thus realize the expansion of the deployable support structure.The concept and operation of the cubic deployable support structure are described in detail.A series of experiments are performed on the three-longeron deployable laminates unit and the simplified cubic deployable support structure to investigate the shape recovery behavior in the deployment process.Results indicate that the cubic deployable support structure has a high deployment-tgo-stowage volume ratio and can achieve self-deployment,package,and deploy without complex mechanical devices. | Fengfeng Li Liwu Liu Xin Lan Xiaojun Zhou Wenfeng Bian Yanju Liu Jinsong Leng | 2016 | International Journal of Smart and Nano Materials2016，7，2： | 1 |
| 7 | Emergence of superconductivity from fully incoherent normal state in an iron-based superconductor (Ba_(0.6)K_(0.4))Fe_2As_2显示文摘In unconventional superconductors, it is generally believed that understanding the physical properties of the normal state is a pre-requisite for understanding the superconductivity mechanism. In conventional superconductors like niobium or lead, the normal state is a Fermi liquid with a well-defined Fermi surface and well-defined quasipartcles along the Fermi surface. Superconductivity is realized in this case by the Fermi surface instability in the superconducting state and the formation and condensation of the electron pairs(Cooper pairing). The high temperature cuprate superconductors, on the other hand, represent another extreme case that superconductivity can be realized in the underdoped region where there is neither well-defined Fermi surface due to the pseudogap formation nor quasiparticles near the antinodal regions in the normal state. Here we report a novel scenario that superconductivity is realized in a system with well-defined Fermi surface but without quasiparticles along the Fermi surface in the normal state.High resolution laser-based angle-resolved photoemission measurements have been performed on an optimally-doped iron-based superconductor(Ba_(0.6)K_(0.4))Fe_2As_2. We find that, while sharp superconducting coherence peaks emerge in the superconducting state on the hole-like Fermi surface sheets, no quasiparticle peak is present in the normal state. Its electronic behaviours deviate strongly from a Fermi liquid system. The superconducting gap of such a system exhibits an unusual temperature dependence that it is nearly a constant in the superconducting state and abruptly closes at Tc. These observations have provided a new platform to study unconventional superconductivity in a non-Fermi liquid system. | Jianwei Huang Lin Zhao Cong Li Qiang Gao Jing Liu Yong Hu Yu Xu Yongqing Cai Dingsong Wu Ying Ding Cheng Hu Huaxue Zhou Xiaoli Dong Guodong Liu Qingyan Wang Shenjin Zhang Zhimin Wang Fengfeng Zhang Feng Yang Qinjun Peng Zuyan Xu Chuangtian Chen Xingjiang Zhou | 2019 | Science Bulletin2019，64，1： | 1 |
| 8 | Interpretation of the Protocol for Prevention and Control of COVID-19 in China(Edition 8)显示文摘BACKGROUND Since the release of Protocol for Prevention and Control of COVID-19(Edition 7),coronavirus disease 2019(COVID-19)control and prevention has been facing new challenges in China with evolving domestic and global epidemiological situations.Since September 2020,China has experienced more than 20 local outbreak waves,all of which were able to be contained within a few weeks. | Fengfeng Liu Canjun Zheng Liping Wang Mengjie Geng Hui Chen Sheng Zhou Lu Ran Zhongjie Li Yanping Zhang Zijian Feng George FGao Zhaorui Chang | 2021 | China CDC weekly2021，3，25： | 1 |
| 9 | Interpretation of the Protocol for Prevention and Control of COVID-19 in China (Edition 7)显示文摘After coronavirus disease 2019(COVID-19),previously known as pneumonia of unknown etiology(PUE)and 2019 novel coronavirus(2019-nCoV),was first discovered in Wuhan City,Hubei Province,the Chinese government took measures to stop the spread of the epidemic nationwide and interrupted local transmission in China(1–2).Although there have been several localized outbreaks that were caused by overseas importation of the virus—including Heilongjiang,Jilin,Beijing,Liaoning,and other provincial-level administrative divisions(PLADs)—these outbreaks have been stopped within two to four weeks and were limited in scope to less than ten cases or a few hundred cases for each event.With the COVID-19 pandemic still uncontrolled globally,the threat of importing the virus continues unabated and still threatens China’s population,virtually all of which is susceptible. | Canjun Zheng Zhaorui Chang Fengfeng Liu Mengjie Geng Hui Chen Jingwei Jiang Sheng Zhou Lu Ran Zhongjie Li Zijian Feng George F.Gao Liping Wang | 2020 | China CDC weekly2020，2，47： | 1 |
| 10 | A novel strategy for screening mutations in the voltage-gated sodium channel gene of Aedes albopictus based on multiplex PCR-mass spectrometry minisequencing technology显示文摘Background The current prevention and control strategy forAedes albopictus heavily relies on comprehensive management, such as environmental management and chemical control. However, the wide application of pyrethroids has facilitated the development of insecticide resistance, primarily via mutations in the voltage-gated sodium channel (VGSC) gene. This study aims to develop a novel strategy for detecting mutations in the VGSC gene inAe. albopictus using multiplex PCR-mass spectrometry (MPCR-MS) minisequencing technology.Methods We established a new strategy for detecting mutations in the VGSC gene inAe. albopictus using MPCR-MS minisequencing technology. MPCR amplification and mass probe extension (MPE) were first used, followed by single nucleotide polymorphism (SNP) typing mass spectrometry, which allows the simultaneous detection of multiple mutation sites of the VGSC gene in 96 samples ofAe. albopictus. A total of 70 wild-collectedAe. albopictus were used to evaluate the performance of the method by comparing it with other methods.Results Three target sites (1016, 1532, 1534) in the VGSC gene can be detected simultaneously by double PCR amplification combined with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry, achieving a detection limit of 20 fg/μl. We applied this method to 70 wild-collectedAe. albopictus, and the obtained genotypes were consistent with the routine sequencing results, suggesting the accuracy of our method.Conclusions MPCR-MS minisequencing technology provides a sensitive and high-throughput approach toAe. albopictus VGSC gene mutation screening. Compared with conventional sequencing, this method is economical and time-saving. It is of great value for insecticide resistance surveillance in areas with a high risk of vector-borne disease. | Qunzheng Mu Xin Zhao Fengfeng Li Wenyu Li Xinxin Zhou Xinchang Lun Yiguan Wang Dongdong Hua Qiyong Liu Di Xiao Fengxia Meng | 2023 | Infectious Diseases of Poverty2023，12，4： | 0 |
| 11 | Red light induces salicylic acid accumulation by activating CaHY5 to enhance pepper resistance against Phytophthora capsici显示文摘Pepper(Capsicum annuum L.)is frequently challenged by various pathogens,among which Phytophthora capsici is the most devastating to pepper production.Red light signal acts as a positive induction of plant resistance against multiple pathogens.However,little is known about how the red light signal affects pepper resistance to P.capsici infection(PCI).Here,we report that red light regulates salicylic acid(SA)accumulation by activating elongated hypocotyl5(CaHY5),a basic leucine zipper(bZIP)transcription factor,thereby decreasing pepper susceptibility to PCI.Exogenous SA treatment reduced pepper susceptibility to PCI,while silencing of CaPHYB(a red light photoreceptor)increased its susceptibility.PCI significantly induced CaHY5 expression,and silencing of CaHY5 reduced SA accumulation,accompanied by decreases in the expression levels of phenylalanine ammonia-lyase 3(CaPAL3),CaPAL7,pathogenesis-related 1(CaPR1),and CaPR1L,which finally resulted in higher susceptibility of pepper to PCI.Moreover,CaHY5 was found to activate the expression of CaPAL3 and CaPAL7,which are essential for SA biosynthesis,by directly binding to their promoters.Further analysis revealed that exogenous SA treatment could restore the resistance of CaHY5-silenced pepper plants to PCI.Collectively,this study reveals a critical mechanism through which red light induces SA accumulation by regulating CaHY5-mediated CaPAL3 and CaPAL7 expression,leading to enhanced resistance to PCI.Moreover,red light-induced CaHY5 regulates pepper resistance to PCI,which may have implications for PCI control in protected vegetable production. | Youxin Yang Yu Li Yelan Guang Jinhui Lin Yong Zhou Ting Yu Fei Ding Yanfeng Wang Jinyin Chen Yanhong Zhou Fengfeng Dang | 2023 | Horticulture Research2023，10，11： | 0 |
| 12 | Plankton respiration in the northern South China Sea during summer and winter显示文摘Plankton respiration is an important part of the carbon cycle and significantly affects the balance of autotrophic assimilation and heterotrophic production in oceanic ecosystems. In the present study, respiration rates of the euphotic zone plankton community(CR_(eu)), size fractionated chlorophyll a concentration(Chl a), bacterial abundance(BAC), and dissolved oxygen concentration(DO) were investigated during winter and summer in the northern South China Sea(n SCS). The results show that there were obvious spatial and temporal variations in CR_(eu) in the n SCS(ranging from 0.03 to 1.10 μmol/(L·h)), CR_(eu) in winter((0.53±0.27) μmol/(L·h)) was two times higher than that in summer((0.26±0.20) μmol/(L·h)), and decreased gradually from the coastal zone to the open sea. The distribution of CR_(eu) was affected by coupled physical-chemical-biological processes, driven by monsoon events. The results also show that CR_(eu) was positively correlated with Chl a, BAC, and DO, and that BAC contributed the highest CR_(eu) variability. Furthermore, the results of the stepwise multiple linear regression suggest that bacteria and phytoplankton were the dominant factors in determining CR_(eu)(R^2 = 0.82, p<0.05) in the n SCS. Based on this relationship, we estimated the integrated water column respiration rate(CRint) within 100 m of the investigated area, and found that the relationship between the biomass of the plankton community and respiration may be nonlinear in the water column. | ZENG Xiangxi HAO Qiang ZHOU Guangdong LE Fengfeng LIU Chenggang ZHOU Wenli | 2018 | Acta Oceanologica Sinica2018，37，8： | 0 |
| 13 | SSR Primer Screening for Marchantia convoluta by SAM Method显示文摘[Objectives] This study was conducted to study SSR primers in wild Marchantia convoluta by SAM method. [Methods] The M. convoluta genomic DNA was extracted by improved CTAB method,and the SSR primers for M. convoluta were selected through digestion,ligation,suppression PCR,pre-amplification,SAM method and PCR. [Results] The improved CTAB method extracted a high purity of DNA; the SAM PCR method gave clear bands; and 100 positive clones were sequenced,obtaining 86 sequences. [Conclusions] The SSR molecular markers could be used for analyzing the genetic diversity of M. convoluta. | Yuefeng WANG Fengfeng XIE Yuqing ZHOU Peilin DU Hua ZHU Jianbei TENG | 2017 | Agricultural Biotechnology2017，6，5： | 0 |
| 14 | Response Time of Reactive Power Based on Different Definitions and Algorithms显示文摘Dynamic reactive power compensation equipment typically requires a fast response to output the necessary reactive power.The term'dynamic response time of reactive power'is often used but has never been clearly defined.This paper summarizes the reactive power calculations under different definitions and algorithms and considers these calculations in terms of signal processing to simulate and analyze the step response.This paper subsequently focuses on the widely used instantaneous reactive power algorithm and finally concludes that the dynamic reactive power response time closely depends on the reactive power calculation method itself.The single-phase instantaneous reactive power algorithm has the fastest response time.The reactive power response time of dynamic reactive devices in power systems is a minimum of a quarter of one cycle time for the well-known and widely used single-phase reactive power algorithms. | Taixun Fang Qiwen Zhou Fengfeng Ding Xiaodan Wu Zhao Li Houjun Tang | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，2： | 0 |
| 15 | Comparison of Biomechanical Characteristics during the Second Landing Phase in Female Latin Dancers:Evaluation of the Bounce and Side Chasse Step显示文摘Research on dance lower extremity joint motion has been limited.Thus,the purpose of this study was to investigate the lower limb biomechanics differences between the side chasse step(SCS)and the bounce step(BS)of the second landing phase in Jive.Thirteen female recreational Latin dancers(Age:22±2.5 years;Height:1.65±0.05 m;Weight:50±4.5 kg;Dance experience:4±2 years)were involved in the experiment.The same music was used throughout the data collection period.We intended to determine whether these two steps generate different kinematic and kinetic data.The ankle,hip,and knee joint angle,moment,velocity,and ground reaction force were calculated for each step.Results demonstrated that the lower limb biomechanics of the two different steps showed significant differences.As a result,strengthening the lower limb muscles(gastrocnemius,Tibialis muscle,and quadriceps)is significantly important to balance the joint strength and prevent foot injury.According to the training time reasonably increasing the heel height should be recognized as important.The current study could provide new insights into reducing lower extremity injuries and improving dance performance. | Fengfeng Li Huiyu Zhou Datao Xu Julien S.Baker Yaodong Gu | 2022 | Molecular & Cellular Biomechanics2022，19，3： | 0 |
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