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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Effects of linagliptin and liraglutide on glucose- and angiotensin Ⅱ-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro显示文摘瞄准:象 Glucagon 一样 peptide-1 (GLP-1 ) 收缩筋和 dipeptidyl peptidase-4 (DPP-4 ) 禁止者不能仅仅降低血葡萄糖层次,而且减轻在心肌的局部缺血和高血压以后的心脏的改变。在现在的学习,我们在葡萄糖上调查了一个 DPP-4 禁止者(linagliptin ) 和 GLP-1 使活跃之物(liraglutide ) 的效果 -- 并且血管收缩素 II (Ang II ) 在 vitro 在心脏的成纤维细胞导致了骨胶原形成和细胞骨架重组,并且阐明相关 mechanisms.Methods:心脏的成纤维细胞从 6-week-old C57BL/6 老鼠的心被孤立,然后为 24 h 暴露了到葡萄糖或 Ang II 的不同集中。fibrotic 的表达式发信号(象 ERK1/2 和 NF-κ 一样的 fibronectin, collagen-1, -3 和 -4), ;在成纤维细胞的 B-p65 用西方的弄污被检验试金。F 肌动朊降级在在成纤维细胞的共焦的显微镜与玫瑰精 phalloidin.Results 染色了的转换激光下面被检测:葡萄糖(1-40 mmol/L ) 和 Ang II (10 −8-10−5 mol/L ) dose-dependently 增加了 fibronectin,骨胶原, phospho-ERK1/2 和 phospho-NF-κ 的表示;在心脏的成纤维细胞的 B-p65。葡萄糖的高集中(≥ 40 mmol/L ) 并且 Ang II (≥ 10 −6 mol/L ) 引起了 F 肌动朊(更少的集会 F 肌动朊纤维和更多拆卸纤维) 的重要降级。ERK1/2 禁止者 U0126 (10 μ mol/L ) 并且 NF-κ B 禁止者 JSH-23 (10 μ mol/L ) 两个显著地压制了葡萄糖 -- 并且血管收缩素在心脏的成纤维细胞的导致 II 的 fibronectin 和骨胶原表情。而且,有 liraglutide (10-100 nmol/L ) 的预告的处理或 linagliptin (3 和 30 nmol/L ) 显著地减少了葡萄糖 -- 并且 fibrotic 信号, phospho-ERK1/2 和 phospho-NF-κ 的 Ang 导致 II 的表示;在心脏的成纤维细胞的 B-p65。而且,然而,有 liraglutide (30 nmol/L ) 的预告的处理或 liraglutide (100 nmol/L ) 显著地禁止了导致葡萄糖的 F 肌动朊降级仅仅 liraglutide 禁止的 Ang 导致 II 的 F 肌动朊 degradation.Conclusion:Linagliptin 和 liraglutide 禁止葡萄糖 -- 并且在经由 ERK/NF-κ 的激活的心脏的成纤维细胞的 Ang 导致 II 的骨胶原形成; B/pathway。Linagliptin 和 liraglutide 显著地也在心脏的成纤维细胞,而是仅仅 liraglutide 禁止导致葡萄糖的 F 肌动朊降级禁止 Ang 导致 II 的 F 肌动朊降级。 | Xian-wei WANG Fen-xi ZHANG Fen YANG Zu-feng DING Nidhi AGARWAL Zhi-kun GUO Jawahar L MEHTA | 2016 | Acta Pharmacologica Sinica2016，37，10： | 3 |
| 3 | Direct amination of benzene to aniline with several typical vanadium complexes显示文摘液体阶段到苯胺的苯的直接催化的胺化作用用一系列钒在醋酸水溶剂被执行(III, IV, V ) 有 N, O-ligands 或 O 的建筑群, O-ligands 作为催化剂和氢氧根胺水疗院氯化物作为 aminating 代理人。钒建筑群比 NaVO 3 或 VOSO 4 向苯胺的生产展出了许多更高的选择。在优化条件, 42.5% 的苯胺收益和有上面的一种高选择的 48 的一吨下面, 99.9% 用 0.2 mmol 被获得[VO (OAc )2] 作为催化剂。 | Yu Fen Lü Liang Fang Zhu Qiu Yuan Liu Bin Guo Xiao Ke Hu Chang Wei Hu | 2009 | Chinese Chemical Letters2009，20，2： | 2 |
| 4 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 5 | In situ electron paramagnetic resonance (EPR) study of surface oxygen species on Au/ZnO catalyst for low-temperature carbon monoxide oxidation显示文摘 | Hao Z Fen L Lu G Q et ol | 2001 | Appl Catal A2001，213，2： | 1 |
| 6 | MicroRNA- 221 targets Bmf in hepatoeellular carcinoma and corre- lates with tumor muhifocality显示文摘 | Gramantieri L Fomari F Fen'acin M | 2009 | Clin Cancer Res2009，15，16： | 1 |
| 7 | Abnormality of bone marrow-derived stem cell in patients with systemic lupus erythematosus显示文摘 | Sun L Y Zhang H Y Fen X B | 2007 | Lupus2007，16，2： | 1 |
| 8 | Theoretical analysis for mechanical erosion of carbon-base materials in ablation 显示文摘 | Ren Fen Sun H S Liu L Y | 1996 | Journal of Thermophysics and Heat Transfer1996，10，4： | 1 |
| 9 | Tilted implants for the restoration of posterior mandibles with horizontal atrophy:an alternative treatment显示文摘 | Pe arrocha Diago M Maestre Fen'in L | 2013 | J Oral Maxillofac Surg2013，71，5： | 1 |
| 10 | Persistence of Paranosema(Nosema)locustae(Microsporidia:Nosematidae)amonggrasshopper(Orthoptera:Acrididae)populations in the InnerMongolia Rangeland,China显示文摘 | Wang P S Wang Y Y Fen L | 2009 | Bio Control2009，54，1： | 1 |
| 11 | Preparation,morphology,and thermoresponsive properties of poly(N-isopropylacrylamide)-based copolymer microgels显示文摘 | Chia Lung L Wen Yen C Chia Fen L | 2006 | Polymer Science:Part A:Polymer Chemistry2006，44，4： | 1 |
| 12 | A de novo mutation of DAXI in a boy with congenital adrenal hypoplasia without hypogo- nadotropic hypogonadism 显示文摘 | Wang CL Fen ZW Liang L | 2014 | J Pediatr Endocrinol Metab2014，27，34： | 1 |
| 13 | Modified support vector machines in financial time series forecasting 显示文摘 | FEN T CAO L J | 2002 | Neurocomputing2002，48，1： | 1 |
| 14 | The dynamic behavior of a gas bubble near a wall 显示文摘 | Zhang A M Yao X L Fen L H | 2009 | Ocean Engineering2009，36，： | 1 |
| 15 | Overexpression of yeast S-adenosylmethionine synthetase metK in Streptomyces actuosus leads to increased production of nosiheptide显示文摘 | Zhang X C Fen M Shi X L | 2008 | Appl Microbiol Biotechnol2008，78，： | 1 |
| 16 | D evelopment of W -band folded w aveguide pulsed TW T s显示文摘 | FEN G Jinjun C A I Jun et a l | 2014 | IEEE Transactions on ElectronD e v ice s2014，61，6： | 1 |
| 17 | Genipin-crosslinked kappa-carrageenan/carboxymethyl cellulose beads and effects on beta-carotene release显示文摘 | Muhamad I I Fen L S Hui N H | | 0，，： | 1 |
| 18 | Switching LPV Control of an F-16 Aircraft via Controller State Reset显示文摘 | Bei L Fen W Sungwan K | 2006 | IEEE Trans on Control Sys- tems Technology2006，14，2： | 1 |
| 19 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 1 |
| 20 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 1 |
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