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| 1 | Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes显示文摘 | Arthur Y. Kim Thomas Kuntzen Joerg Timm Brian E. Nolan Melanie A. Baca Laura L. Reyor Andrew C. Berical Andrea J. Feller Kristin L. Johnson Julian Schulze Zur Wiesch Gregory K. Robbins Raymond T. Chung Bruce D. Walker Mary Carrington Todd M. Allen Georg M | 2011 | Gastroenterology2011，，2： | 1 |
| 2 | Crystallization and preliminary X-ray diffraction studies of a-amylase from the Antarctic psychrophile Aleromonas halopanctis A23 显示文摘 | Aghajari Nushin Feller georges Gerday Charles Haser Richard | 1996 | Protein sci1996，，5： | 1 |
| 3 | Xylanases ,xylanase families and extremophilic xylanases 显示文摘 | Collins Tony Gerday Charles Feller Georges | 2005 | FEMS Microbiology Reviews2005，29，： | 1 |
| 4 | Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes显示文摘 | Arthur Y. Kim Thomas Kuntzen Joerg Timm Brian E. Nolan Melanie A. Baca Laura L. Reyor Andrew C. Berical Andrea J. Feller Kristin L. Johnson Julian Schulze Zur Wiesch Gregory K. Robbins Raymond T. Chung Bruce D. Walker Mary Carrington Todd M. Allen Georg M | 2011 | Gastroenterology2011，，2： | 1 |
| 5 | Xylanases,xylanase families and extremophilic xylanases显示文摘 | Tony Collins Charles Gerday Georges Feller | 2005 | FEMS Microbiology Reviews2005，，29： | 1 |
| 6 | Did psychrophilic enzymes really win the challenge?显示文摘 | Laurent Zecchinon Paule Claverie Tony Collins Salvino D’Amico Daniel Delille Georges Feller Daphné Georlette Emmanuelle Gratia Anne Hoyoux Marie-Alice Meuwis Guillaume Sonan Charles Gerday | 2001 | Extremophiles2001，，5： | 1 |
| 7 | Xylanases, xylanase families and extremophilic xylanases 显示文摘 | Tony Collins Charles Gerday Georges Feller | 2005 | FEMS Mierobiol Rev2005，29，： | 1 |
| 8 | Lipase from psychotropic antarctic bacteria显示文摘 | Georges Feller Michel Thiry Jean-Louis Arpigny | 1990 | FEMS Microbiology Letters1990，，66： | 1 |
| 9 | Xylanases, xylanase families and extremophilic xylanases 显示文摘 | Tony Collins Charles Gerday Georges Feller | 2005 | FEMS Microbiology Reviews2005，29，： | 1 |
| 10 | A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer显示文摘 | Merle Hanke Kai Hoefig Hartmut Merz Alfred C. Feller Ingo Kausch Dieter Jocham Jens M. Warnecke Georg Sczakiel | 2010 | Urologic Oncology: Seminars and Original Investigations2010，，6： | 1 |
| 11 | Xylanases,xylanase families and extremophilic xylanases显示文摘 | Tony Collins Charles Gerday Georges Feller | 2005 | FEMS Microbiology Reviews2005，29，： | 1 |
| 12 | Xylanases, xylanase families and extremophilic xylanases显示文摘 | Tony Collins Charles Gerday Georges Feller | 2005 | FEMS Microbiology Reviews2005，29，1： | 1 |
| 13 | Psychrophilic enzymes: a thermodynamic challenge显示文摘 | Gerday Charles Aittaleb Mohamed Arpigny Jean Louis Baise Etienne Chessa Jean-Pierre Garsoux Genevieve Petrescu loan Feller Georges | 1997 | Biochim Biophys Acta1997，1342，2： | 1 |
| 14 | Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes显示文摘 | Arthur Y. Kim Thomas Kuntzen Joerg Timm Brian E. Nolan Melanie A. Baca Laura L. Reyor Andrew C. Berical Andrea J. Feller Kristin L. Johnson Julian Schulze Zur Wiesch Gregory K. Robbins Raymond T. Chung Bruce D. Walker Mary Carrington Todd M. Allen Georg M | 2011 | Gastroenterology2011，，2： | 1 |
| 15 | Genomic landscape of pancreatic neuroendocrine tumors显示文摘AIM:To investigate the prognostic role of genomic stability and copy number alterations(CNAs)pancreatic neuroendocrine tumors(Pan NETs).METHODS:A high-resolution array-based comparative genomic hybridization approach was utilized in order to investigate and quantify chromosomal aberrations in a panel of 37 primary Pan NET and 11 metastatic samples.DNA samples were extracted from formalinfixed and paraffin-embedded tumor specimen.Genomic findings were correlated with histopathological and immunohistochemical data.Moreover,the dataset was subjected to employing an unsupervised hierarchical clustering analysis approach utilizing Euclidean distance and average linkage and associations between genomically defined tumor groups and recurrent CNAs or clinicopathological features of the study group were assessed.RESULTS:Numerous chromosomal aberrations were recurrently detected in both,primary tumor samples and metastases.Copy number gains were most frequently observed at 06p22.2-p22.1(27.1%),17p13.1(20.8%),07p21.3-p21.2(18.8%),09q34.11(18.8%).Genomic losses were significantly less frequent and the only recurrent aberration affected 08q24.3(6.3%).Moreover,we detected a high degree of genomic heterogeneity between primary tumors and metastatic lesions.Unsupervised hierarchical clustering of loci affected by CNAs in more than 3 primary tumor samples revealed two genetically distinct tumor groups as well as two chromosomal clusters of genomic imbalances indicating a small subset of tumors with common molecular features(13.5%).Aberrations affecting6p22.2-22.1,8q24.3,9q34.11 and 17p13.1(P=0.011;0.003;0.003;0.001),were significantly associated with a poorer survival prognosis.CONCLUSION:This study suggests that several frequent CNAs in numerous candidate regions are involved in the pathogenesis and metastatic progression of PanNET. | Niklas Gebauer Christian Schmidt-Werthern Veronica Bernard Alfred C Feller Tobias Keck Nehara Begum Dirk Rades Hendrik Lehnert Georg Brabant Christoph Thorns | 2014 | World Journal of Gastroenterology2014，20，46： | 0 |
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