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| 1 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 2 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 3 | CFinder:locating cliques and overlapping modules in biological networks显示文摘 | Adamcsek B Palla G Farkas I J | 2006 | Bioinformatics2006，22，8： | 1 |
| 4 | CFinder:Locating cliques and overlapping modules in biological networks显示文摘 | Adamcsek B Palla G Farkas I J | 2006 | Bioinformatits2006，22，8： | 1 |
| 5 | Continuous adrninistra?tion of sorafenib in combination with transarterial che?moembolization in patients with hepatocellular carcino?ma s results of a phase I study显示文摘 | DufourJ Fv Hoppe H Heim M H Helbling B Mau?rho fer 0 Szucs- Farkas Z | 2010 | Oncoiogist2010，15，11： | 1 |
| 6 | Predictive validity of end- points used in electrophysiological modelling of migraine in the tri- geminovascular system显示文摘 | Farkas B Kardos P Orosz S | 2015 | Brain Res2015，1625，： | 1 |
| 7 | P2X3 and P2X2/3 receptor antagonists 显示文摘 | Bolcskei H Farkas B | 2014 | Pharm Pat Anal2014，3，1： | 1 |
| 8 | Effect of thermal treatment on moisture transport during steam cooking of skipjack tuna (Katsuwonas pelamis)显示文摘 | BELL J W FARKAS B E HALE S A | 2001 | J Food Scie2001，66，2： | 1 |
| 9 | 1-stage feminizing genitoplasty: 8 years of experience with 49 cases 显示文摘 | Farkas A Chertin B Hadas Halpren I | 2001 | J Urol2001，165，62： | 1 |
| 10 | Muramyldipeptide modu- lates CXCL-8 release of BEAS-2B cells via NOD2 显示文摘 | Farkas L Stoelcked B Jentsch N | 2008 | Stand J Immunol2008，68，3： | 1 |
| 11 | CFinder:locating cliques and overlapping modules in biological networks显示文摘 | Adamcsek B Palla G Farkas I J | 2006 | Bioinformatics2006，22，8： | 1 |
| 12 | Optical characterization of PLD grown ni- trogen-doped TiO2 thin films显示文摘 | Farkas B | 2008 | Appl Surf Sci2008，254，11： | 1 |
| 13 | CFinder:locating clique and overlapping modules in biological networks 显示文摘 | ADAMCSEK B PALLA G FARKAS I | 2005 | BIOINFORMATICS APPLICATIONS NOTE2005，00，00： | 1 |
| 14 | 1-Stage feminizing genitoplasty:8 years of experience with 49 cases显示文摘 | Farkas A Chertin B Hada~Halpren I | 2001 | J Urol2001，165，62： | 1 |
| 15 | Endoscopictreatment of vesicoureteral reflux associated with uret-erocele显示文摘 | Chertin B Mohanan N Farkas A | 2007 | J Urol2007，178，： | 1 |
| 16 | Calcium isotopic fractionation between clinopy- roxene and orthopyroxene from mantle perido- tites显示文摘 | HUANG S C FARKAS J JACOBSEN S B | 2010 | Earth & Planetary Science Letters2010，292，34： | 1 |
| 17 | Analysis of risk factors-especially different types of plexitis-for postoperative relapse in Crohn's disease显示文摘AIM To evaluate the presence of submucosal and myenteric plexitis and its role in predicting postoperative recurrence.METHODS Data from all patients who underwent Crohn's disease(CD)-related resection at the University of Szeged, Hungary between 2004 and 2014 were analyzed retrospectively. Demographic data, smoking habits, previous resection, treatment before and after surgery, resection margins, neural fiber hyperplasia, submucosal and myenteric plexitis were evaluated as possible predictors of postoperative recurrence. Histological samples were analyzed blinded to the postoperative outcome and the clinical history of the patient. Plexitis was evaluated based on the appearance of the most severely inflamed ganglion or nerve bundle. Patients underwent regular follow-up with colonoscopy after surgery. Postoperativerecurrence was defined on the basis of endoscopic and clinical findings, and/or the need for additional surgical resection. RESULTS One hundred and four patients were enrolled in the study. Ileocecal, colonic, and small bowel resection were performed in 73.1%, 22.1% and 4.8% of the cases, respectively. Mean disease duration at the time of surgery was 6.25 years. Twenty-six patients underwent previous CD-related surgery. Forty-three point two percent of the patients were on 5-aminosalicylate, 20% on corticosteroid, 68.3% on immunomodulant, and 4% on anti-tumor necrosis factor-alpha postoperative treatment. Postoperative recurrence occurred in 61.5% of the patients; of them 39.1% had surgical recurrence. 92.2% of the recurrences developed within the first five years after the index surgery. Mean disease duration for endoscopic relapse was 2.19 years. The severity of submucosal plexitis was a predictor of the need for second surgery(OR = 1.267, 95%CI: 1.000-1.606, P = 0.050). Female gender(OR = 2.21, 95%CI: 0.98-5.00, P = 0.056), stricturing disease behavior(OR = 3.584, 95%CI: 1.344-9.559, P = 0.011), and isolated ileal localization(OR = 2.671, 95%CI: 1.033-6.910, P = 0.043) were also predictors of postoperative recurrence. No association was revealed between postoperative recurrence and smoking status, postoperative prophylactic treatment and the presence of myenteric plexitis and relapse.CONCLUSION The presence of severe submucosal plexitis with lymphocytes in the proximal resection margin is more likely to result in postoperative relapse in CD. | Agnes Milassin Anita Sejben László Tiszlavicz Zita Reisz Gyorgy Lázár Mónika Szucs Renáta Bor Anita Bálint Mariann Rutka Zoltán Szepes Ferenc Nagy Klaudia Farkas Tamás Molnár | 2017 | World Journal of Gastrointestinal Surgery2017，9，7： | 1 |
| 18 | Induction of Hsp90 protein expression in malignant melanomas anti melanoma metastases 显示文摘 | Becker B Multhoff G Farkas B | 2004 | Exp Dermatol2004，13，1： | 1 |
| 19 | Case studies of bibliothey with homeless children显示文摘 | Farkas GS Yorker B | 1993 | Issues in mental health nursing1993，14，4： | 1 |
| 20 | Stable calcium isotopic compositions of Hawaiian shield lavas: Evidence for recycling of ancient marine carbonates into the mantle显示文摘 | HUANG S C FARKAS J JACOBSEN S B | 2011 | Geochim Cosmochim Acta2011，75，17： | 1 |
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