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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 3 | Factors related to quality of life in patients with cirrhosis and ascites: Relevance of serum sodium concentration and leg edema显示文摘 | Elsa Solà Hugh Watson Isabel Graupera Fanny Turón Rogelio Barreto Ezequiel Rodríguez Marco Pavesi Vicente Arroyo Mónica Guevara Pere Ginès | 2012 | Journal of Hepatology2012，，6： | 3 |
| 4 | Operational oil-slick characterization by SAR imagery and synergistic data显示文摘 | Fanny G A Grgoire M Fabrice C | 2005 | IEEE Journal of OceanicEngineering2005，30，3： | 1 |
| 5 | Influence of hydrolysis degree on the functional properties of salmon byproducts hydrolysates 显示文摘 | GBOGOURI G A LINDER M FANNI J | 2004 | J Food Sci2004，69，： | 1 |
| 6 | Characterisation of sealed anodic films on 7050 T74 and 2214 T6 aluminum alloys显示文摘 | Fanny S Christlme B Georges M | 2002 | Surface and Coatings Technology2002，154，1： | 1 |
| 7 | Influence of hydrolysis degree on the functional properties of salmon byproducts hydrolysates 显示文摘 | Gbogouri G A Linder M Fanni J | 2004 | Journal of Food Science2004，69，8： | 1 |
| 8 | Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase显示文摘 | Fanni S. Kálmán Beáta Lizák Szilvia K. Nagy Tamás Mészáros Veronika Zámbó József Mandl Miklós Csala éva Kereszturi | 2013 | Biochimie2013，，7： | 1 |
| 9 | R eduction o fpostoperative ile u s by early enteral n u tritio n in patientsundergoing m ajor re cta l surgery: prospective, random ized,co n tro lle d tria l 显示文摘 | Petra G Fanny F Luyer M isha D | 2014 | Ann Surg2014，259，4： | 1 |
| 10 | The NLRP3 inflammasomeis activated by nanoparticles through ATP,ADP and adenosine 显示文摘 | Baron L Gombault A Fanny M | 2015 | Cell Death Dis2015，6，： | 1 |
| 11 | Effect of heating boundary conditions on pool boiling experiments 显示文摘 | DARABI J OHADI M M FANNI M A | 1999 | HVAC&R Research1999，5，4： | 1 |
| 12 | Influence of hydrolysis degree on the functional properties of salmon byproduct hydrolysates 显示文摘 | GBOGOURI G A LINDER M FANNI J | 2004 | J Food Sci2004，69，： | 1 |
| 13 | Characterization of sealed a- nodic films on 7050 T74 and 2214 T6 aluminum alloys显示文摘 | Fanny S Christine B Georges M | 2002 | Sur- face and Coatings Technology2002，154，1： | 1 |
| 14 | Influence of hydroly- sis degree on the functional properties of salmon by product hy- drolysates显示文摘 | Gbogouri G A Linder M Fanni J | 2004 | Journal of Food Science2004，69，8： | 1 |
| 15 | Protein Recovery From Veal Bones by Enzymatic Hydrolysis 显示文摘 | Linder M Fanni J Parmentier M | 1995 | J of Food Sci1995，60，5： | 1 |
| 16 | A New Approach to Digital FIR Filter Design Using the Tabu Search显示文摘 | BELBACHIR elbachi BELBACHIR M F FANNI A | 2000 | IEEE NORdic SIGnal Processing Symposium NORSIG''00 13-15 June Kolmarden-Sweden2000，2000，： | 1 |
| 17 | Partially supervised oil-slick detection by SAR imagery using kernel expansion显示文摘 | GREGOIRE M FANNY G A | 2006 | IEEE Transactions on Geoscience and Remote Sensing2006，44，： | 1 |
| 18 | An infrequeney scale for the Chinese MMPI显示文摘 | Cheung Fanny M Song Wei zheng Butcher James N | 1991 | Psychological Assessment1991，3，4： | 1 |
| 19 | A Sequential Robust Method to Finite Wordlength Coefficient FIR Digital Filter Design显示文摘 | BELBACHIR A N BELBACHIR M F FANNI A | 2000 | IEEE NORdic SIGnal Processing Symposium NORSIG''00 13-15 June Kolrnarden Sweden2000，2000，： | 1 |
| 20 | New crack stop hole shape using structural optimizing technique 显示文摘 | FANNI M FOUDA N SHABARA M A N | 2015 | Ain Shams Engineering Journal2015，6，3： | 1 |
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