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| 1 | Partial Beclin 1 silencing aggravates doxorubicin-and Fasinduced apoptosis in HepG2 cells显示文摘瞄准:在 HepG2 房间的危险性上调查 Beclin 1 的角色在反船边交货抗体或 doxorubicin 治疗以后经历 apoptosis。方法:Beclin 1 silencing 用 RNA 干扰被完成。DNA 倍性, apoptotic 房间的百分比和 mitochondrial 膜电位被流动血细胞计数估计。多形核白细胞(自动数据处理核糖) 的 Beclin 1, Bcl-X (L) 和细胞色素 c,和劈开聚合酶(PARP ) 的层次是由使用西方的污点的 assayed。结果:Beclin 1 表示在 Beclin 1 siRNA transfection 以后由 75% 72 h 减少了。部分 Beclin 1 silencing 显著地增加了 subG1 房间的百分比有 doxorubicin 或反船边交货抗体的 24 和 40 h 术后疗法,分别地并且这 potentiation 被处理与一个 pan-caspase 禁止者废除。部分 Beclin 1 silencing 也增加了 PARP 劈开, mitochondrial 膜去极和 cytosolic 细胞色素 c。部分 Beclin 1 silencing 的 pro-apoptotic 后果没在 Bcl-X (L) 表示与衰落被联系。结论:部分 Beclin 1 silencing 在与反船边交货抗体或与 doxorubicin 对待的 HepG2 房间加重 mitochondrial permeabilization 和 apoptosis。 | Fanny Daniel Agnès Legrand Dominique Pessayre Nathalie Vadrot Véronique Descatoire Dominique Bernuau | 2006 | World Journal of Gastroenterology2006，12，18： | 11 |
| 2 | c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1显示文摘AIM: To investigate the effect of stable c-Fos overexpression on immortalized human hepatocyte (IHH) proliferation. METHODS: IHHs stably transfected with c-Fos (IHH-Fos) or an empty vector (IHH-C) were grown in medium supplemented with 1% serum or stimulated with 10% serum. Cell proliferation was assessed by cell counts, 3H-thymidine uptake and fl ow cytometry analyses. The levels of cell cycle regulatory proteins (Cyclin D1, E, A) cyclin dependent kinases (cdk) cdk2, cdk4, cdk6, and their inhibitors p15, p16, p21, p27, to- tal and phosphorylated GSK-3β and epidermal growth factor receptor (EGF-R) were assayed by Western blot- ting. Analysis of Cyclin D1 mRNA levels was performed by reverse transcription-polymerase chain reaction and real-time polymerase chain reaction (PCR) analysis. Stability of Cyclin D1 was studied by cycloheximide blockade experiments. RESULTS: Stable c-Fos overexpression increased cell proliferation under low serum conditions and resulted in a two-fold increase in [3H]-thymidine incorpora- tion following serum addition. Cell cycle analysis by fl ow cytometry showed that c-Fos accelerated the cell cycle kinetics. Following serum stimulation, Cyclin D1 was more abundantly expressed in c-Fos overexpressing cells. Cyclin D1 accumulation did not result from increased transcriptional activation, but from nuclear stabilization. Overexpression of c-Fos correlated with higher nuclear levels of inactive phosphorylated GSK- 3β, a kinase involved in Cyclin D1 degradation and higher levels of EGF-R mRNA, and EGF-R protein compared to IHH-C both in serum starved, and in serum stimulated cells. Abrogation of EGF-R signalling in IHH- Fos by treatment with AG1478, a specif ic EGF-R tyrosine kinase inhibitor, prevented the phosphorylation of GSK-3β induced by serum stimulation and decreased Cyclin D1 stability in the nucleus. CONCLUSION: Our results clearly indicate a positive role for c-Fos in cell cycle regulation in hepatocytes. Importantly, we delineate a new mechanism by which c-Fos could contribute to hepatocarcinogenesis through stabilization of Cyclin D1 within the nucleus, evoking a new feature to c-Fos implication in hepatocellular carcinoma. | Meryem Güller Kahina Toualbi-Abed Agnès Legrand Laurence Michel Alain Mauviel Dominique Bernuau Fanny Daniel | 2008 | World Journal of Gastroenterology2008，14，41： | 6 |
| 3 | Thalidomide in systemic mastocytosis: results from an open‐label, multicentre, phase II study显示文摘 | Bérengère Gruson Olivier Lortholary Danielle Canioni Olivia Chandesris Fanny Lanternier Julie Bruneau Bernard Grosbois Cristina Livideanu Claire Larroche Isabelle Durieu Stéphane Barete Henri Sevestre Momar Diouf Guillaume Chaby Jean‐Pierre Marolleau Patr | 2013 | Br J Haematol2013，，3： | 1 |
| 4 | Toll-like receptor 9 signaling mediates te anti-inflammatory effects of probiotics in murine experimental colitis 显示文摘 | Daniel Rachilewitz Kyoko Katakura Fanny Karmeli | 2004 | Gastroenterol2004，126，2： | 1 |
| 5 | Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis显示文摘 | Daniel E R Giselle S Fanny A | 2004 | The Journal of Infectious Diseases2004，190，4： | 1 |
| 6 | Somatostatin effectively prevents ethanol-and NSAID-induced gastric mucosal damage in rats显示文摘 | Fanny Karmeli BSc Rami Eliakim MD Elimelech Okon MD Daniel Rachmilewitz MD | 1994 | Digestive Diseases and Sciences1994，，3： | 1 |
| 7 | Identification of a Novel Gene on Chromosome 7q11.2 Interrupted by a Translocation Breakpoint in a Pair of Autistic Twins显示文摘 | Razia Sultana Chang-En Yu Jun Yu Jeffery Munson Donghui Chen Wenhui Hua Annette Estes Fanny Cortes Flora de la Barra Dongmei Yu Syed T. Haider Barbara J. Trask Eric D. Green Wendy H. Raskind Christine M. Disteche Ellen Wijsman Geraldine Dawson Daniel R. S | 2002 | Genomics2002，，： | 1 |
| 8 | Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary *uberculosis 显示文摘 | Daniel ER Giselle S Fanny A | 2004 | The Journal of Infectious Diseases2004，190，4： | 1 |
| 9 | Toll-like receptor 9 signaling mediates te anti-inflammatory effects of probiotics in murine experimental colitis显示文摘 | Daniel Rachilewitz Kyoko Katakura Fanny Karmeli | 2004 | Gastroenterol2004，126，2： | 1 |
| 10 | Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation显示文摘 | Eran Goldin Fanny Karmeli ZVI Selinger Daniel Rachmilewitz | 1989 | Digestive Diseases and Sciences1989，，5： | 1 |
| 11 | Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis显示文摘 | Daniel Rachmilewitz Kyoko Katakura Fanny Karmeli Tomoko Hayashi Constantin Reinus Bernard Rudensky Shizuo Akira Kiyoshi Takeda Jongdae Lee Kenji Takabayashi Eyal Raz | 2004 | Gastroenterology2004，，2： | 1 |
| 12 | Somatostatin effectively prevents ethanol-and NSAID-induced gastric mucosal damage in rats显示文摘 | Fanny Karmeli BSc Rami Eliakim MD Elimelech Okon MD Daniel Rachmilewitz MD | 1994 | Digestive Diseases and Sciences1994，，3： | 1 |
| 13 | Altered Endoplasmic Reticulum Stress Affects Translation in Inactive Colon Tissue From Patients With Ulcerative Colitis显示文摘 | Xavier Tréton Eric Pédruzzi Dominique Cazals–Hatem Alain Grodet Yves Panis André Groyer Richard Moreau Yoram Bouhnik Fanny Daniel Eric Ogier–Denis | 2011 | Gastroenterology2011，，3： | 1 |
| 14 | Effect of Ambient Temperature and Humidity Conditions on the Efficacy of Organic Treatments against Varroa destructor in Different Climatic Zones of Chile显示文摘 | Aldea Patricia Rodriguez Rafael Olivares Alejandra Farffin Macarena Riveros Daniel Nfifiez Fanny Trivelli Luz | 2013 | Journal of Agricultural Science and Technology(A)2013，3，6： | 0 |
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