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| 1 | Epidermal growth factor improves intestinal morphology by stimulating proliferation and differentiation of enterocytes and mTOR signaling pathway in weaning piglets显示文摘Epidermal growth factor(EGF) has been shown to improve piglet intestinal morphology and epithelial recovery. In an attempt to further understand the mechanisms behind these improvements, this study tested the hypothesis that dietary EGF may affect intestinal morphology by stimulating the proliferation and differentiation of enterocytes in weaning piglets. In piglets receiving200 μg kg^-1 EGF, crypt depth and villus height increased(P<0.05). Adding 400 μg kg^-1 EGF increased villus height-to-crypt depth ratio(P<0.05), but reduced crypt depth(P<0.05). Dietary supplementation with 200 μg kg^-1 EGF significantly increased the number of Ki67-positive cells(P<0.01) and tended to increase the mRNA level of proliferating cell nuclear antigen(P<0.10).However, this supplementation decreased the expression level of intestinal fatty acid-binding protein(P<0.05). Piglets fed with400 μg kg^-1 EGF had an increased mRNA level of intestinal alkaline phosphatase(P<0.05). The phosphorylation of m TOR(mammalian target of rapamycin) was observed in the 200 μg kg^-1 EGF group. These results suggest that dietary supplementation with a low level of EGF improved piglet intestinal morphology through stimulating the proliferation and differentiation of enterocytes, and the mTOR signaling pathway may partly be involved in this process. | Lixia Wang Fan Zhu Huansheng Yang Jianzhong Li Yali Li Xueqin Ding Xia Xiong Fengjie Ji Hanlin Zhou Yulong Yin | 2020 | Science China(Life Sciences)2020，63，2： | 7 |
| 2 | Rapid on-line non-destructive detection of the moisture content of corn ear by bioelectrical impedance spectroscopy显示文摘Moisture content of corn directly affects its quality and storage time,and the rapid on-line detection of the moisture content of corn ears not threshed or in vivo in the fields is required.Because of the special shape of corn ear,the rapid,low cost and non-destructive bioelectrical impedance measurement is more suitable for its moisture content detection.Using the four-electrode method with the Agilent E4980A precision LCR meter,the electrical impedance spectroscopies of the sweet corn ears and waxy corn ears at different moisture contents were acquired.The frequency range of the detection was from 20 Hz to 2 MHz and to enhance the contact,the attached-type electrodes were wrapped in cotton soaked with 0.1%NaCl solution.The impedance data over the frequency range from 300 Hz to 5 kHz were used to obtain the parameters of the bio-impedance Cole-Cole model.The results showed a good linear correlation(coefficient of determination R2=0.960)between the equivalent parallel resistance R∞of sweet corn ear and the moisture content value determined by standard chemical method.The research proved that the bioelectrical impedance spectroscopy can be used for detecting the moisture content of corn ear. | Zhao Pengfei Zhang Hanlin Zhao Dongjie Wang Zhijie Fan Lifeng Huang Lan Ma Qin Wang Zhongyi | 2015 | International Journal of Agricultural and Biological Engineering2015，8，6： | 3 |
| 3 | Research on the Heat Transfer Characteristics of a Loop Heat Pipe Used as Mainline Heat Transfer Mode for Spacecraft显示文摘An experimental research is conducted on the heat transfer characteristics of a loop heat pipe(LHP)used in the'mainline'heat transfer mode for spacecraft platform thermal control.The heat from multiple instruments scattered in different locations is collected by thermal control techniques such as axially grooved heat pipes and then transmitted to the radiant surface for dissipation through the LHP in an unified way.The research contents include the start-up characteristics,the operational stability characteristics,the operational blocking characteristics,the continuous blocking characteristics,the heat transfer capability,the thermal resistance,and the dynamic response characteristics under the change of the heat sink temperature.The results show that the higher the auxiliary starting power is,the easier it is to start the LHP;the higher the input power of the thermoelectric cooler is,the more beneficial it is to speed up the stabilization of the vapor-liquid interface in the condenser;the higher the blocking power,the shorter the blocking time of the LHP;the LHP can be operated stably within the heat sink temperature alteration process;the heat transfer ability is higher than 500 W with a systematic thermal resistance of 0.037℃/W. | WANG Lu MIAO Jianyin GONG Mingming ZHOU Qiangu LIU Changu ZHANG Hongxing FAN Hanlin | 2019 | Journal of Thermal Science2019，28，4： | 2 |
| 4 | Study on heattransfer performance of spray cooling: model and analysis 显示文摘 | Zhao Rui Cheng Wenlong Liu Qinie Fan Hanlin | 2010 | HeatMass Transfer2010，46，： | 1 |
| 5 | Comparison of Reference Genes for Transcriptional Studies in Postmortem Human Brain Tissue Under Different Conditions显示文摘Dear Editor Research on neurodegenerative diseases is a hot topic worldwide[1],and MRI,genetics and epigenetics,and animal models have been commonly used.Considering species differences,research on human brain samples is irreplaceable(2)Many countries and regions have built brain banks to collect and store brain tissue from donors.Samples provided by a brain bank can be used to study synaptic structure,protein,DNA,RNA[3,4],and lipids to illuminate the pathological mechanisms underlying neurodegenerative diseases.When brain tissue is used for gene expression research,the quantitative real-time polymerase chain reaction(RT-qPCR)is an accurate method,which simultaneously amplifies and quantifies the expression of target genes by measuring the intensity of fluorescence in each PCR cycle. | Qing Zhang Hanlin Zhang Fan Liu Qian Yang Kang Chen Pan Liu Tianyi Sun Chao Ma Wenying Qiu Xiaojing Qian | 2019 | Neuroscience Bulletin2019，35，2： | 0 |
| 6 | Coordinating Zirconium Nodes in Metal-Organic Framework with Trifluoroacetic Acid for Enhanced Lewis Acid Catalysis显示文摘Regulating Lewis acid sites with well-defined electronic state and steric environment is still challenging for achieving high catalytic efficiency.Here we show coordinating zirconium nodes in the typical metal-organic framework known as MOF-545 with the monocarboxylate modulators including trifluoroacetic acid(TFA)or benzoic acid(BA)over meso-tetra(4-carboxyphenyl)-porphine(H_(2)TCPP),denoted as MOF-545-TFA or MOF-545-BA.Impressively,MOF-545-TFA shows the significantly enhanced performance for the catalytic ring-opening reaction of various epoxides with alcohols and good recyclability at 40°C in respect with MOF-545-BA and ZrO_(2).This mainly originates from the stronger Lewis acidity and more active zirconium sites induced by the electron-withdrawing TFA,resulting in the increased ability for activation of epoxides.This modulation approach is promising for enlarging the toolbox to extend the MOFs-based Lewis acid catalysis. | WANG Wenyang LIU Hanlin YANG Caoyu FAN Ting CUI Chengqian LU Xiaoquan TANG Zhiyong LI Guodong | 2022 | Chemical Research in Chinese Universities2022，38，5： | 0 |
| 7 | Inter-tissue communication of mitochondrial stress and metabolic health显示文摘Mitochondria function as a hub of the cellular metabolic network.Mitochondrial stress is closely associated with aging and a variety of diseases,including neurodegeneration and cancer.Cells autonomously elicit specific stress responses to cope with mitochondrial stress to maintain mitochondrial homeostasis.Interestingly,mitochondrial stress responses may also be induced in a non-autonomous manner in cells or tissues that are not directly experiencing such stress.Such non-autonomous mitochondrial stress responses are mediated by secreted molecules called mitokines.Due to their significant translational potential in improving human metabolic health,there has been a surge in mitokine-focused research.In this review,we summarize the findings regarding inter-tissue communication of mitochondrial stress in animal models.In addition,we discuss the possibility of mitokine-mediated intercellular mitochondrial communication originating from bacterial quorum sensing. | Hanlin Zhang Xinyu Li Wudi Fan Sentibel Pandovski Ye Tian Andrew Dillin | 2023 | Life Metabolism2023，2，1： | 0 |
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