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| 1 | Connexin 43 hemichannels protect bone loss during estrogen deficiency显示文摘Estrogen deficiency in postmenopausal women is a major cause of bone loss,resulting in osteopenia,osteoporosis,and a high risk for bone fracture.Connexin 43 (Cx43) hemichannels (HCs) in osteocytes play an important role in osteocyte viability,bone formation,and remodeling.We showed here that estrogen deficiency reduced Cx43 expression and HC function.To determine if functional HCs protect osteocytes and bone loss during estrogen deficiency,we adopted an ovariectomy model in wild-type (WT) and two transgenic Cx43 mice:R76W (dominant-negative mutant inhibiting only gap junction channels) and Cx43 Δ130–136 (dominant-negative mutant compromising both gap junction channels and HCs).The bone mineral density (BMD),bone structure,and histomorphometric changes of cortical and trabecular bones after ovariectomy were investigated.Our results showed that the Δ130–136 transgenic cohort had greatly decreased vertebral trabecular bone mass compared to WT and R76W mice,associated with a significant increase in the number of apoptotic osteocyte and empty lacunae.Moreover,osteoclast surfaces in trabecular and cortical bones were increased after ovariectomy in the R76W and WT mice,respectively,but not in Δ130–136 mice.These data demonstrate that impairment of Cx43 HCs in osteocytes accelerates vertebral trabecular bone loss and increase in osteocyte apoptosis,and further suggest that Cx43 HCs in osteocytes protect trabecular bone against catabolic effects due to estrogen deficiency. | Liang Ma Rui Hua Yi Tian Hongyun Cheng Roberto Jose Fajardo Joseph J. Pearson Teja Guda Daniel Brian Shropshire Sumin Gu Jean X. Jiang | 2019 | Bone Research2019，7，2： | 11 |
| 2 | Sudden cardiac death during Holter recording in a patient with vasospastic angina显示文摘 | Arias MA Sanehez AM Fajardo A | 2012 | Int J Cardiol2012，18，2： | 1 |
| 3 | Difficulty with evacuation after spinal cord injury:colonic motility during sleep and effects of ab- dominal wall stimulation 显示文摘 | Korsten MA Fajardo NR Rosman AS | 2004 | J Rehabil Res Dev2004，41，1： | 1 |
| 4 | Avoiding complications and decreasing costs of central venous catheter placement utilizing electrocadiographic guidance显示文摘 | Francis KR Picard DL Fajardo MA | 1992 | Surg Gynecol Obstet1992，175，： | 1 |
| 5 | Estimating the morbidity profile amongst Colombian civil aviation personnel显示文摘 | Salamanca MA Fajardo HA | 2009 | Rev Salud Pu blica (Bogota)2009，11，： | 1 |
| 6 | Effects of phorbol ester and dexamethasone treatment on histidine decarboxylase and ornithine decarboxylase in basophilic cells 显示文摘 | Fajardo I Urdiales JL Medina MA | 2001 | Biochem Pharmacol2001，61，9： | 1 |
| 7 | Adenosquamous carcinoma arising in a mucinous cystadenoma of the pancreas显示文摘 | Campman SC Fajardo MA Rippon MB | 1997 | J Surg Oncol1997，64，2： | 1 |
| 8 | Sudden cardiac death during Hoher re- cording in a patient with vasospastic angina显示文摘 | Arias MA Shnchez AM Fajardo A | 2007 | Int J Cardiol2007，118，2： | 1 |
| 9 | Prolonged ambulatory colonic manometric studies using endoclips显示文摘 | Fajardo N Hussain K Korsten MA | 2000 | Gastroint- est Endosc2000，51，2： | 1 |
| 10 | Difficulty with evacuation after spinal cord injury:Colonic motility during sleep and effects of abdominal wall stimulation显示文摘 | Korsten MA Fajardo NR Rosman AS | | 0，，： | 1 |
| 11 | Undemutrition does not alter the activation of LB-cell neogenesis and replication in adult rats after partial pancreatectomy显示文摘 | Fernandez MA Martin S Fajardo A | 2006 | Am J Physiol Endocrinol Metab2006，291，6： | 1 |
| 12 | Estimating the morbidity profile amongst Colombian civil aviation personnel显示文摘 | Salamanca MA Fajardo HA | | 0，，： | 1 |
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