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9篇 您的检索式：作者名="Fabiola L"

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		题名	作者	年代	出处	被引量
	1	Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population显示文摘Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in NAFLD.Methods: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of PCR.Results: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P < 0.01) and triglycerides(TGL)(TT vs XA; P < 0.01) were observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4(rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase(ALT)(CA + AA vs CC; P = 0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P < 0.01) and those who were more obese(32.2 vs 29.0 kg/m2,P < 0.01). In addition, serum glucose and insulin levels increased significantly in the presence of NASH.Conclusions: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients.	Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro Rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa	2018	Hepatobiliary & Pancreatic Diseases International2018，17，4：	2
	2	Comparable early changes in gastrointestinal hormones after sleeve gastrectomy and Roux-En-Y gastric bypass surgery for morbidly obese type 2 diabetic subjects显示文摘	Fabiola Romero Joana Nicolau Lílliam Flores Roser Casamitjana Ainitze Ibarzabal Antonio Lacy Josep Vidal	2012	Surgical Endoscopy2012，，8：	1
	3	Leptin promotes meiotic pro - gression and developmental capacity of bovine oocytesvia cumulus cell - independent and dependent mechanisms 显示文摘	FABIOLA F PAULA L MARC B	2007	Biol Reprod2007，76，3：	1
	4	DC activa- ted via dectin-1 convert Treg into IL-17 producers显示文摘	Fabiola O Gut-Landmann SL Matthias L etal	2008	Eur J Immunol2008，38，：	1
	5	Diagnostic potential of circulating mi R-499-5p in elderly patients with acute non ST-elevation myocardial infarction显示文摘	Fabiola O Roberto A Maria L	2012	International Journal of Cardiology2012，1，：	1
	6	Lymph Node Ratio as a Predictor of Survival in Gastric Carcinoma显示文摘	Medina-Franco Heriberto Cabrera-Mendoza Francisco Almaguer-Rosales Susana Guillén Fabiola Suárez-Bobadilla Yoli L Sánchez-Ramon Ariadne	2013	The American Surgeon2013，，3：	1
	7	α-Mangostin: anti-inflammatory activity and metabolism by human cells 显示文摘	FABIOLA G O CHUREEPORN C GREGORY B L	2013	Agric Food Chem2013，61，16：	1
	8	Tissue culture regeneration of a medicinal plant from Mexico:Piper auritum Kunth显示文摘	Fabiola D Xavier L James S	2006	Hort Science2006，41，：	1
	9	Genetic associa- tion analysis of chronic mountain sickness in an Andean high- altitude population 显示文摘	Olga M M Josef T P Fabiola L	2005	Haematologica2005，90，：	1

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