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| 1 | High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy显示文摘BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation therapy.Due to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor growth.Transarterial chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in LT.However,it remains unclear if one of those treatment options is superior.The analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by histopathology.AIM To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT alone.METHODS In this multicenter retrospective study,27 patients who received liver transplantation for HCC were analyzed.Patients received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver transplantation.Liver explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging therapies.Statistical analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U tests.RESULTS Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and SBRT.There were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor lesions.Strikingly,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests that a combination of TACE and SBRT increases the rate of complete histopathological response compared to TACE or SBRT alone in bridging to liver transplantation. | Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 2 | The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma显示文摘 | Andreas Jordan Regina Scholz Klaus Maier-Hauff Frank K.H. Landeghem Norbert Waldoefner Ulf Teichgraeber Jens Pinkernelle Harald Bruhn Fabian Neumann Burghard Thiesen Andreas Deimling Roland Felix | 2006 | Journal of Neuro - Oncology2006，，1： | 1 |
| 3 | The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma显示文摘 | Andreas Jordan Regina Scholz Klaus Maier-Hauff Frank K.H. Landeghem Norbert Waldoefner Ulf Teichgraeber Jens Pinkernelle Harald Bruhn Fabian Neumann Burghard Thiesen Andreas Deimling Roland Felix | 2006 | Journal of Neuro - Oncology2006，，1： | 1 |
| 4 | Beyond cost reduction:improving the value of energy storage in electricity systems显示文摘From a macro-energy system perspective,an energy storage is valuable if it contributes to meeting system objectives,including increasing economic value,reliability and sustainability.In most energy systems models,reliability and sustainability are forced by constraints,and if energy demand is exogenous,this leaves cost as the main metric for economic value.Traditional ways to improve storage technologies are to reduce their costs;however,the cheapest energy storage is not always the most valuable in energy systems.Modern techno-economical evaluation methods try to address the cost and value situation but do not judge the competitiveness of multiple technologies simultaneously.This paper introduces the‘market potential method’as a new complementary valuation method guiding innovation of multiple energy storage.The market potential method derives the value of technologies by examining common deployment signals from energy system model outputs in a structured way.We apply and compare this method to cost evaluation approaches in a renewables-based European power system model,covering diverse energy storage technologies.We find that characteristics of high-cost hydrogen storage can be more valuable than low-cost hydrogen storage.Additionally,we show that modifying the freedom of storage sizing and component interactions can make the energy system 10% cheaper and impact the value of technologies.The results suggest looking beyond the pure cost reduction paradigm and focus on developing technologies with suitable value approaches that can lead to cheaper electricity systems in future. | Maximilian Parzen Fabian Neumann Adriaan H.Van Der Weijde Daniel Friedrich Aristides Kiprakis | 2022 | Carbon Neutrality2022，1，1： | 0 |
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