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| 1 | Use of probiotics for prevention of radiation-induced diarrhea显示文摘AIM: To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-induced diarrhea in cancer patients. METHODS: This was a double-blind, placebo-controlled trial. Four hundred and ninety patients who underwent adjuvant postoperative radiation therapy after surgery for sigmoid, rectal, or cervical cancer were assigned to either the high-potency probiotic preparation VSL#3 (one sachet t.i.d.,) or placebo starting from the first day of radiation therapy. Efficacy endpoints were incidence and severity of radiation-induced diarrhea, daily number of bowel movements, and the time from the start of the study to the use of loperamide as rescue medication. RESULTS: More placebo patients had radiation-induced diarrhea than VSL#3 patients (124 of 239 patients, 51.8%, and 77 of 243 patients, 31.6%; P < 0.001) and more patients given placebo suffered grade 3 or 4 diarrhea compared with VSL#3 recipients (55.4% and 1.4%, P < 0.001). Daily bowel movements were 14.7 ± 6 and 5.1 ± 3 among placebo and VSL#3 recipients (P < 0.05), and the mean time to the use of loperamide was 86 ± 6 h for placebo patients and 122 ± 8 h for VSL#3 patients (P < 0.001). CONCLUSION: Probiotic lactic acid-producing bacteria are an easy, safe, and feasible approach to protect cancer patients against the risk of radiation-induced diarrhea. | P Delia G Sansotta V Donato P Frosina G Messina C De Renzis G Famularo | 2007 | World Journal of Gastroenterology2007，13，6： | 29 |
| 2 | Two pathways for base excision repair in mammalian cells显示文摘 | Frosina G Fortini P Rossi O | 1996 | J Biol Chem1996，271，16： | 1 |
| 3 | Intraepithelial CDS+ tumor-infiltrating lymphocytes and a high CD8+/regnlatory T cell ratio are associated with favorable prognosis in ovarian cancer显示文摘 | Sato E Olson SH Ahn J Bundy B Nishikawa H Qian F Jungbluth AA Frosina D Gnjatic S Ambrosone C Kepner J Odunsi T Ritter G Lele S Chen YT Ohtani H Old LJ Odunsi K | 2005 | Proc Natl Acad Sci USA2005，102，18： | 1 |
| 4 | The bright and the dark sides of DNA repair in stem cells显示文摘 | Frosina G | 2010 | J Biomed Biotechnol2010，2010，84： | 1 |
| 5 | Counteracting spontaneous transformation via overexpression of rate-limiting DNA base excision repair enzymes显示文摘 | Frosina G | 2001 | Carcinogenesis2001，22，9： | 1 |
| 6 | Stem cell-mediated delivery of therapies in the treatment of glioma显示文摘 | Frosina G | 2011 | Mini Rev Med Chem2011，11，7： | 1 |
| 7 | Frontiers in targeting glioma stem cells 显示文摘 | Frosina G | 2011 | Eur J Canc-er2011，47，4： | 1 |
| 8 | Involvement of XRCCl and DNA ligase III gene products in DNA base excision repair显示文摘 | CAPPELLI E TAYLOR R CEVASCO M ABBONDANDOLO A CALDECOTT K FROSINA G | 1997 | J Biol Chem1997，272，23： | 1 |
| 9 | Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against streptozotocin-induced diabetes显示文摘 | Cubeddu TL Frosina G | 1985 | Diabetologia1985，28，9： | 1 |
| 10 | Frontiers in targeting glioma stem cells 显示文摘 | Frosina G | 2011 | Eur J Cancer2011，47，4： | 1 |
| 11 | Stem Cell-Mediated Delivery of Therapies in the Treat- ment of Glioma 显示文摘 | Frosina G | 2011 | Mini-Reviews in Medicinal Chemistry2011，11，7： | 1 |
| 12 | Gene prophylaxis by a DNA repair function显示文摘 | FROSINA G | 2007 | Mol Aspects Med2007，28，34： | 1 |
| 13 | DNA repair and resistance of gliomas to chemotherapy and radiotherapy显示文摘 | Frosina G | 2009 | Mol Cancer Res2009，7，7： | 1 |
| 14 | DNA repair and resistance of gliomas to chemotherapy and radiotherapy显示文摘 | Frosina G | 2009 | Mol Cancer Res2009，7，7： | 1 |
| 15 | Counteracting spontaneous transformation via overexpression of rate-limiting DNA base excision repair enzymes 显示文摘 | Frosina G | 2001 | Carcinogenesis2001，22，9： | 1 |
| 16 | Effect of topoisomerase poisoning by antitumor drugs VM26,fostriecin and camptothecin on DNA repair replication by mammalian cell extracts显示文摘 | Frosina G Rossi O | 1992 | Carcinogenesis1992，13，8： | 1 |
| 17 | Delayed formation of FancD2 foci in glioma stem cells treated with ionizing radiation 显示文摘 | Cappeni E Vecehio D Frosina G | 2012 | J Cancer Res Clin Oncol2012，138，5： | 1 |
| 18 | The bright and the dark sides of DNA repair in stem cells 显示文摘 | Frosina G | 2010 | J Biomed Biotechnol2010，，84： | 1 |
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