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| 1 | Delayed gastric emptying following pancreaticoduodenectomy:Incidence,risk factors,and healthcare utilization显示文摘AIM To characterize incidence and risk factors for delayed gastric emptying(DGE) following pancreaticoduodenectomy and examine its implications on healthcare utilization. METHODS A prospectively-maintained database was reviewed. DGE was classified using International Study Group of Pancreatic Surgery criteria. Patients who developed DGE and those who did not were compared. RESULTS Two hundred and seventy-six patients underwent pancreaticoduodenectomy(PD)(> 80% pyloruspreserving, antecolic-reconstruction). DGE developed in 49 patients(17.8%): 5.1% grade B, 3.6% grade C. Demographic, clinical, and operative variables were similar between patients with DGE and those without. DGE patients were more likely to present multiplecomplications(32.6% vs 4.4%, ≥ 3 complications, P < 0.001), including postoperative pancreatic fistula(POPF)(42.9% vs 18.9%, P = 0.001) and intra-abdominal abscess(IAA)(16.3% vs 4.0%, P = 0.012). Patients with DGE had longer hospital stay(median, 12 d vs 7 d, P < 0.001) and were more likely to require transitional care upon discharge(24.5% vs 6.6%, P < 0.001). On multivariate analysis, predictors for DGE included POPF [OR = 3.39(1.35-8.52), P = 0.009] and IAA [OR = 1.51(1.03-2.22), P = 0.035].CONCLUSION Although DGE occurred in < 20% of patients after PD, it was associated with increased healthcare utilization. Patients with POPF and IAA were at risk for DGE. Anticipating DGE can help individualize care and allocate resources to high-risk patients. | Somala Mohammed George Van Buren II Amy Mc Elhany Eric J Silberfein William E Fisher | 2017 | World Journal of Gastrointestinal Surgery2017，9，3： | 13 |
| 2 | Pancreatic cancer: Advances in treatment显示文摘Pancreatic cancer is a leading cause of cancer mortality and the incidence of this disease is expected to continue increasing.While patients with pancreatic cancer have traditionally faced a dismal prognosis,over the past several years various advances in diagnosis and treatment have begun to positively impact this disease.Identification of effective combinations of existing chemotherapeutic agents,such as the FOLFIRINOX and the gemcitabine+nab-paclitaxel regimen,has improved survival for selected patients although concerns regarding their toxicity profiles remain.A better understanding of pancreatic carcinogenesis has identified several pre-malignant precursor lesions,such as pancreatic intraepithelial neoplasias,intraductal papillary mucinous neoplasms,and cystic neoplasms.Imaging technology has also evolved dramatically so as to allow early detection of these lesions and thereby facilitate earlier management.Surgery remains a cornerstone of treatment for patients with resectable pancreatic tumors,and advances in surgical technique have allowed patients to undergo resection with decreasing perioperative morbidity and mortality.Surgery has also become feasible in selected patients with borderline resectable tumors as a result of neoadjuvant therapy.Furthermore,pancreatectomy involving vascular reconstruction and pancreatectomy with minimally invasive techniques have demonstrated safety without significantly compromising oncologic outcomes.Lastly,a deeper understanding of molecular aberrations contributing to the development of pancreatic cancer shows promise for future development of more targeted and safe therapeutic agents. | Somala Mohammed George Van Buren Ⅱ William E Fisher | 2014 | World Journal of Gastroenterology2014，20，28： | 8 |
| 3 | Pancreatic endometrial cyst mimics mucinous cystic neoplasm of the pancreas显示文摘Pancreatic cysts include a variety of benign, premalignant, and malignant lesions. Endometrial cysts in the pancreas are exceedingly rare lesions that are difficult to diagnose pre-operatively. This report describes the findings in a 43-year-old patient with a recent episode of acute pancreatitis who presented with a large cyst in the tail of the pancreas. Imaging demonstrated a loculated pancreatic cyst, and cyst fluid aspiration revealed an elevated amylase and carcinoembryonic antigen. The patient experienced an interval worsening of abdominal pain, fatigue, diarrhea, and a 15-pound weight loss 3 mo after the initial episode of pancreatitis. With concern for a possible pre-malignant lesion, the patient underwent a laparoscopic distal pancreatectomy with splenectomy, which revealed a 16cm×12cm×4cm lesion. Final histopathology was consistent with an intra-pancreatic endometrial cyst. Here we discuss the overlapping imaging and laboratory features of pancreatic endometrial cysts and mucinous cystic neoplasms of the pancreas. | Michael A Mederos Nicole Villafane Sadhna Dhingra Carlos Farinas Amy Mc Elhany William E Fisher George Van Buren II | 2017 | World Journal of Gastroenterology2017，23，6： | 7 |
| 4 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 5 | Renormalization Group Theory: Its Basis and Formulation in Statistical显示文摘 | Fisher M E | 1998 | Physics Rev Mod Phys1998，70，： | 3 |
| 6 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 7 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 8 | Rare gas abundances in MORB 显示文摘 | Fisher D E | 1986 | Geochim Cosmochim Acta1986，50，： | 2 |
| 9 | Depth EEG studies in the Lennox-Gastaut syndrome 显示文摘 | Fisher RS Niedermeyer E | 1987 | Clin Electroencephalogr1987，18，4： | 1 |
| 10 | Laser capture microdisaection for analysis of macrophage gene expression from athernsclerotic lesions 显示文摘 | Trogan E Fisher EA | 2005 | Methods Mol Biol2005，293，： | 1 |
| 11 | Nutrient limitation of phytoplankton in Chesapeake Bay显示文摘 | FISHER T R DEELE E R AMMERMAN T W | 1992 | Marine Ecological Progress Series1992，82，1： | 1 |
| 12 | The p53 tumor suppressor:critical regulator of life & death in cancer显示文摘 | FISHER D E | 2001 | Apoptosis2001，6，12： | 1 |
| 13 | The p53 tumor suppressor:critical regulator of Iife&death in cancer显示文摘 | Fisher D E | 2001 | Apoptosis2001，6，12： | 1 |
| 14 | Automated approach for ribosomal intergenic spacer analysis of microbial diversity and its application to freshwater bacterial communities 显示文摘 | Fisher M M Triplett E W | 1999 | Applied and Environmental Microbiology1999，65，： | 1 |
| 15 | Risk factors for high-risk proliferative diabetic retinopathy and severe visual loss:Early treatment diabetic retinopathy study report 18显示文摘 | Davis M D Fisher M R Gangnon R E | 1998 | Invest Ophthalmol Vis Sci1998，39，： | 1 |
| 16 | Separation and Preconcentration of Strontium From Biological Envionmental, and Nuclear Waste Samples by Extraction Chromatography Using a Crown Ether显示文摘 | Horwitz E P Dietz M L Fisher D D | 1991 | Anal Chem1991，63，： | 1 |
| 17 | PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimization of coupling techniques 显示文摘 | Francis C E Fisher D Delgado C | 1998 | Int J Hematol1998，68，3： | 1 |
| 18 | Relationship of pretreatment transurethral resection of the prostate to survival without distant metastases in patients treated with ^125I-implantation for localized prostatic cancer显示文摘 | Fowler J E Jr Fisher H A Kaiser D L | 1984 | Cancer1984，53，9： | 1 |
| 19 | Effect of preoperative chemo-therapy on local-regional disease in women with operable breast canc-er:findings from National Surgical Adjuvant Breast and Bowel Project B-18 显示文摘 | Fisher B Brown A Mamounas E | 1997 | J Clin Oncol1997，15，7： | 1 |
| 20 | Phase II trial of bicalutamide in patients with advanced prostate cancer in whom conventional hormonal therapy failed:a Southwest Oncolo- gy Group study (SWOG 9235) 显示文摘 | KUCUK O FISHER E MOINPOUR CM | 2001 | Urology2001，58，1： | 1 |
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