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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)显示文摘 | Fiona McPhee Amy K. Sheaffer Jacques Friborg Dennis Hernandez Paul Falk Guangzhi Zhai Steven Levine Susan Chaniewski Fei Yu Diana Barry Chaoqun Chen Min S. Lee Kathy Mosure Li-Qiang Sun Michael Sinz Nicholas A. Meanwell Richard J. Colonno Jay Knipe Paul S | 2012 | Antimicrobial Agents and Chemotherapy2012，，10： | 2 |
| 3 | White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury显示文摘 | Fernando Malee S Simpson Jolie E Matthews Fiona | 2006 | Stroke2006，37，6： | 1 |
| 4 | Expression stability of commonly used reference genes in canine articular connective tissues 显示文摘 | DUNCAN A DYLAN N C FIONA S | 2007 | BMC Vet Res2007，3，： | 1 |
| 5 | The Fas-FADD death domain complex structure unravels signaling by receptor clustering显示文摘 | Fiona L Bouguslaw S Cristina P | | 0，，7232： | 1 |
| 6 | Novel approaches to detect serum biomarkers for clinical response to interferon - β treatment in multiple sclerosis显示文摘 | Kaushal S Fiona C Eve D | 2010 | Plos One2010，5，10： | 1 |
| 7 | Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patients 显示文摘 | Nitin S Fiona B Ralph R | 2007 | Hum Mol Genet2007，16，： | 1 |
| 8 | Human inhibitor of apoptosis proteins:why xiap is the black sheep of the family显示文摘 | Brendan P Eckelman Guy S Salvesen Fiona L Scott | | 0，，： | 1 |
| 9 | Sequence variation in two lignin biosynthesis genes,cinnamoyl Co -A reductase (CCR) and cinnamyl alcohol dehydrogenase 2 (CAD2)显示文摘 | FIONA S P RENE E V ROBERT C E | 2003 | Molecular Breeding2003，12，： | 1 |
| 10 | Predicting extractives, lignin and cellulose contents using near infrared spectroscopy onsolid wood in Eucalyptus globulus显示文摘 | Fiona S Poke Carolyn A Raymond | 2006 | Wood Chemistry and Technology2006，26，2： | 1 |
| 11 | Heavy metals in vegetables collected from production and market sites of a tropical urban area of India显示文摘 | Rajesh K S Madhoolika Agrawal Fiona M Marshall | 2009 | Food and Chemical Toxicology2009，47，： | 1 |
| 12 | Gender-specific association of the angiotensin converting enzyme gene with Alzheimer' s disease显示文摘 | Fiona C Laila A John S | | 0，，： | 1 |
| 13 | Psychological week environment and sickness absence among British civil servants: the Whitehall Ⅱ study 显示文摘 | Fiona M North S Leonard Syme Amanda Feeney | 1996 | Am J Public Health1996，86，： | 1 |
| 14 | Subtotal hepatectomy: a porcine model for the study of liver regeneration显示文摘 | Fiona G Court Peter E Laws Charles P Morrison Benjamin D Teague Matthew S Metcalfe Simon A Wemyss-Holden Ashley R Dennison Guy J Maddern | 2004 | Journal of Surgical Research2004，，1： | 1 |
| 15 | Predicting extractives, lignin and cellulose contents using near infrared spectroscopy on solid wood in Eucalyptus globulus 显示文摘 | Fiona S Poke Carolyn A Raymond | 2006 | Wood Chemistry and Technology2006，26，： | 1 |
| 16 | Heavy metals in vegetables collected from production and market sites of a tropical urban area of India显示文摘 | RAJESH K S MADHOOLIKA A FIONA M M | 2009 | Food and Chemical Toxi-cology2009，47，： | 1 |
| 17 | Amorphous calcium carbonate is stabilized in confinement 显示文摘 | Christopher S J Sophie L F Fiona M C Hugo C K | 2010 | Advanced Functional Materials2010，20，13： | 1 |
| 18 | Heavy metal(Cu,Zn,Cd and Pb) contamination of vegetables in urban India:a case study in Varanas显示文摘 | Rajesh K S Madhoolika A Fiona M M | 2008 | Environmental Pollution2008，154，2： | 1 |
| 19 | Heavy metal con-tamination of soil and vegetables in suburban areas of Va-ranasi, India 显示文摘 | Rajesh K S Madhoolika A Fiona M | 2007 | Ecotoxicology and Environmental Safety2007，66，： | 1 |
| 20 | Heavy metal contamination of soil and vegetables in suburban areas of Varanasi显示文摘 | Rajesh K S Madhoolika A Fiona M | 2007 | Ecotoxicology and Environmental Safety2007，66，2： | 1 |
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