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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 3 | Postcholecystectomy syndrome an algorithmic approach显示文摘 | Filip M Saftoiu A Popescu C | 2009 | Gastrointestin Liver Dis2009，18，1： | 1 |
| 4 | Cationic liposomes for gene delivery显示文摘 | Simaes S Filipe A Faneca H Mano M Penacho N Dtizgiines N | 2005 | Expert Opin Drug Deliv2005，2，： | 1 |
| 5 | Microcystin-LR induced DNA damage in human peripheral blood lymphocytes显示文摘 | Zegura B Gajski G Straser A Garaj-Vrhovac V Filipic?M | 2011 | Mutat Res2011，726，2： | 1 |
| 6 | Postcholecystectomy syndromes-an algorithmic approach 显示文摘 | Filip M Saftoiu A Popescu C | 2009 | J Gastrointestin Liver Dis2009，18，1： | 1 |
| 7 | Effects of serotonin (5 -HT) (1B) receptor ligands on cocaine-seeking behavior in rats 显示文摘 | Przeglinski E Golda A Filip M | 2008 | Phannacol Rep2008，60，6： | 1 |
| 8 | Remote sensing of global wetland dynamics with multiple satellite data sets显示文摘 | Catherine P Elaine M Filipe A | 2001 | Geophysical Researeh Letters2001，28，15： | 1 |
| 9 | Cylindrospermopsin induced transcriptional responses in human hepatoma Hep G2 cells显示文摘 | Straser A Filipic?M Zegura B | 2013 | Toxicol In Vitro2013，27，6： | 1 |
| 10 | An expeditious method for the determination of organochlorine pesticides residues in estuarine sediments using microwave assisted pre-extraction and automated headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry 显示文摘 | Pedro N C Pedro N R Filipe A Rafael E Maria C P Teresa M V | 2008 | Talanta2008，76，5： | 1 |
| 11 | A model for radi- ation-induced bystander effects, with allowance for spatial po- sition and the effects of cell turnover显示文摘 | Little M P Filipe J A N Prise K M | 2005 | Journal of Theoreti- cal Biology2005，232，3： | 1 |
| 12 | Ozonation of a landfill leachate: evaluation of toxicity removal and biode gradability improvement显示文摘 | BILA D M FILIPE M A SILVA A C | 2005 | Journal of Hazardous Materi als2005，117，2： | 1 |
| 13 | The effect of amphetamine sensitization on mouse immunoreactivity显示文摘 | KUBERA M FILIP M BASTA-KAIM A | 2002 | J Physiol Pharmacol2002，53，2： | 1 |
| 14 | Vanadium haloperoxidases from brown algae of the Laminariaceae family显示文摘 | Almeida M Filipe S Humanes M Maia M F Melo R Severino N Da Silva J A L Da Silva J J R F Wever R | 2001 | Phytochemistry2001，57，： | 1 |
| 15 | Statistical queuing theory with some applications显示文摘 | Ferreira M A M Andrade M Filipe J A | 2012 | International Journal of Latest Trends in Finance and Economic Sci- ences2012，1，4： | 1 |
| 16 | Influence of Fulvic Acids and Copper Ions on Thiram Determination in Water显示文摘 | FILIPE O M S VIDAL M M DUARTE A C | 2008 | Journal of Agricultural and Food Chemistry2008，56，16： | 1 |
| 17 | Post- cholecystectomy syndromes an algorithmic ap- proach 显示文摘 | Filip M Saftoiu A Popescu C | 2009 | J Gastrointestin Liver Dis2009，18，1： | 1 |
| 18 | Prognostic value of proliferating cell nuclear antigen in gastric carcinoma显示文摘 | FILIPE M I HALL P A | 1991 | J Clin Pathol1991，44，： | 1 |
| 19 | Fractionation of Cu, Pb and Zn in certified reference soils SRM 2710 and SRM 2711 using the optimized BCR sequential extraction procedure 显示文摘 | Ross A S Filip M G | 2003 | Advances in Environmental Research2003，8，1： | 1 |
| 20 | Influence of fulvic acids and copper ions on thiram determination in water 显示文摘 | Filipe O M S Vidal M M Duarte A C | 2008 | Journal of Agricultural and Food Chemistry2008，56，16： | 1 |
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