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| 1 | Diabetes and cancer:Looking at the multiligand/RAGE axis显示文摘The association between diabetes and hyperglycemia and the associated increased risk of several solid and hematologic malignancies has been the subject of investigation for many years.Although the association is not fully understood,current knowledge clearly indicates that diabetes may influence malignant cell transformation by several mechanisms,including hyperinsulinemia,hyperglycemia and chronic inflammation.In this context,the receptor for advanced glycation end-products (RAGE) has emerged as a focal point in its contribution to malignant transformation and tumor growth.We high-light how RAGE,once activated,as it manifests itself in conditions such as diabetes or hyperglycemia,is able to continuously bring about an inflammatory milieu,thus supporting the contribution of chronic inflammation to the development of malignancies. | Armando Rojas Ileana González Erik Morales Ramón Pérez-Castro Jacqueline Romero Héctor Figueroa | 2011 | World Journal of Diabetes2011，2，7： | 11 |
| 2 | Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. | Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete | 2012 | World Journal of Gastroenterology2012，18，11： | 6 |
| 3 | Advances in CO 2 capture technology—The U.S. Department of Energy’s Carbon Sequestration Program显示文摘 | José D. Figueroa Timothy Fout Sean Plasynski Howard McIlvried Rameshwar D. Srivastava | 2007 | International Journal of Greenhouse Gas Control2007，，1： | 3 |
| 4 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 5 | Inflammatory bowel disease: A descriptive study of 716 local Chilean patients显示文摘AIM: To demographically and clinically characterize inflammatory bowel disease(IBD) from the local registry and update data previously published by our group.METHODS: A descriptive study of a cohort based on a registry of patients aged 15 years or older who were diagnosed with IBD and attended the IBD program at Clínica Las Condes in Santiago, Chile. The registry was created in April 2012 and includes patients registered up to October 2015. The information was anonymously downloaded in a monthly report, and the information on patients with more than one visit was updated. The registry includes demographic, clinical and disease characteristics, including the Montreal Classification, medical treatment, surgeries and hospitalizations for crisis. Data regarding infection with Clostridium difficile(C. difficile) were incorporated in the registry in 2014. Data for patients who received consultations as second opinions and continued treatment at this institution were also analyzed. RESULTS: The study included 716 patients with IBD: 508 patients(71%) were diagnosed with ulcerative colitis(UC), 196 patients(27%) were diagnosed with Crohn's disease(CD) and 12 patients(2%) were diagnosed with unclassifiable IBD. The UC/CD ratio was 2.6/1. The median age was 36 years(range 16-88), and 58% of the patients were female, with a median age at diagnosis of 29 years(range 5-76). In the past 15 years, a sustained increase in the number of patients diagnosed with IBD was observed, where 87% of the patients were diagnosed between the years 2001 and 2015. In the cohort examined in the present study, extensive colitis(50%) and colonic involvement(44%) predominated in the patients with UC and CD, respectively. In CD patients, nonstricturing/non-penetrating behavior was more frequent(80%), and perianal disease was observed in 28% of the patients. There were significant differences in treatment between UC and CD, with a higher use of corticosteroids, and immunosuppressive and biological therapies was observed in the patients with CD(P < 0.05 and P < 0.01). Significant surgical differences were also observed: 5% of the UC patients underwent surgery, whereas 38% of the CD patients required at least one surgery(P < 0.01). The patients with CD were hospitalized more often during their disease course than the patients with UC(55% and 35% of the patients, respectively; P < 0.01). C. difficile infection was acquired by 5% of the patients in each group at some point during the disease course. Nearly half of the patients consulted at the institution for a second opinion, and 32% of these individuals continued treatment at the institution. CONCLUSION: IBD has continued to increase in the study cohort, slowly approaching the level reported in developed countries. | Daniela Simian Daniela Fluxá Lilian Flores Jaime Lubascher Patricio Ibánez Carolina Figueroa Udo Kronberg Raúl Acuna Mauricio Moreno Rodrigo Quera | 2016 | World Journal of Gastroenterology2016，22，22： | 2 |
| 6 | Oxidative stress in tumor microenvironment--Its role in angiogenesis显示文摘The tumor angiogenesis process is believed to be dependent on an 'angiogenic switch' formed by a cascade of biologic events as a consequence of the 'cross-talk' between tumor cells and several components of local microenvironment including endothelial cells, macrophages, mast cells and stromal components. Oxidative stress represents an important stimulus that widely contributes to this angiogenic switch, which is particularly relevant in lungs, where oxidative stress is originated from different sources including the incomplete reduction of oxygen during respiration, exposure to hypoxia/reoxygenation, stimulated resident or chemoattracted immune cells to lung tissues, as well as by a variety of chemicals compounds. In the present review we highlight the role of oxidative stress in tumor angiogenesis as a key signal linked to other relevant actors in this complex process. | Armando ROJAS Raul SILVA Hectcr FIGUEROA Miguel A MORAINES | 2008 | 中国肺癌杂志2008，11，3： | 2 |
| 7 | Anatomic hepatectomy as a definitive treatment for hepatolithiasis: a cohort study显示文摘 | Nicolás Jarufe Eduardo Figueroa César Mu?oz Fabrizio Moisan Julian Varas José R. Valbuena Claudia Bambs Jorge Martínez Fernando Pimentel | 2012 | HPB2012，，9： | 2 |
| 8 | Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer显示文摘 | Moisé s Blanco-Calvo Nuria Tarrí o Margarita Reboredo Mar Haz-Conde Jorge Garcí a Marí a Quindó s Angé lica Figueroa Luis Antó n-Aparicio Lourdes Calvo Manuel Valladares-Ayerbes | 2014 | Future Oncol2014，，7： | 2 |
| 9 | Peripheral neuropathy incidence in inflammatory bowel disease: A population-based study显示文摘 | Juan J. Figueroa Edward V. Loftus William S. Harmsen P. James B. Dyck Christopher J. Klein | 2013 | Neurology2013，，18： | 2 |
| 10 | Treatment of anaerobic sludge digester effluents by the CANON process in an air pulsing SBR显示文摘 | J.R. Vázquez-Padín M.J. Pozo M. Jarpa M. Figueroa A. Franco A. Mosquera-Corral J.L. Campos R. Méndez | 2008 | Journal of Hazardous Materials2008，，1： | 2 |
| 11 | Nitrogen removal efficiencies and microbial communities in full-scale IFAS and MBBR municipal wastewater treatment plants at high COD:N ratio显示文摘The relative locations of AOB,NOB,and DNB were examined for three different kinds of carriers in two types of hybrid bioflm process configurations:integrated fixed-film activated sludge(IFAS)and moving bed bioflm reactor(MBBR)processes.IFAS water resource recovery facilities(WRRFs)used Anodkainess^TM K1 carriers(KC)at Broomfield,Colorado,USA and polypropylene resin crriers(R)at Fukuok,Japa,whic MBBR WRFS used KC crier at South Adams Couty,Colorado,USA and sponge carriers(SC)at Saga,Japan.Influent COD to N ratios ranged from 8:1 to 15:1.The COD and BOD removal efficiencies were high(96%-98%);NH^+4-N and TN removal efficiencies were more varied at 72%98%and 64%-77%,respectively.The extent of TN removal was higher at high SRT,high COD:N ratio and low DO concentration in the anoxic tank.In IFAS,RC with high specific surface area.(SSA)maintained higher AOB population than KC.Sponge carriers with high SSA maintained higher overall bacteria population than KC in MBBR systems.However,the DNB were not more abundant in high SSA crriers.The diversity of AOB,NOB,and DNB was fairly similar in different carriers.Nitrosomonas sp.dominated over Nitrosospira sp.while denitrifying bacteria included Rhodobacter sp.,Sulfuritalea sp.,.Rubrivivax sp:Paracoccus sp..and Pseudomonas sp.The results from this work suggest that high SRT,high.COD:N ratio,low DO concentration in anoxic tanks,and carriers with greater surface area may be recommended for high COD,BOD and TN removal in WRRFs with IFAS and MBBR systerms. | Supaporn Phanwilai Naluporn Kangwannarakul Pongsak(Lek)Noophan Tamao Kasahara Akihiko Terada Junko Munakata-Marr Linda Ann Figueroa | 2020 | Frontiers of Environmental Science & Engineering2020，14，6： | 2 |
| 12 | Diversity, frequency, and geographic distribution of facultative bacterial endosymbionts in introduced aphid pests显示文摘在昆虫的容许的细菌的 endosymbionts 在最后年期间在强烈学习下面。Endosymbionts 能修改昆虫显型,授与在环境应力下面的适应优点。,这为一组全球农业的蚜虫害虫似乎特别地相关 endosymbionts 修改关键健康相关的特点包括主人植物使用,对生来的敌人和热忍耐的保护。试图在介绍蚜虫害虫,分发和许多的成功上理解容许的 endosymbionts 的角色 5 容许的 endosymbionts ( Hamiltonella defensa , Regiella insecticola , Serratia symbiotica ,立克次休属微生物和 Spiroplasma )在 4 个谷物蚜虫被学习并且比较( Sitobion avenae , Diuraphis noxia , Metopolophium dirhodum 和 Schizaphis graminium )并且在从在智利的 2 个 agroclimatic 地区的豌豆蚜虫 Acyrthosiphon pisum 建筑群。总的来说,有容许的 endosymbionts 的感染展出了取决于蚜虫种类 / 主人赛跑和地理地区的一个高度可变、典型的模式,它能在他们的介绍以后解释蚜虫害虫人口的成功。当时 S。symbiotica 和 H。defensa 是 A 带的最经常的 endosymbionts。pisum 豌豆赛跑和 A。分别地,最经常的容许的 endosymbiont 由所有谷物蚜虫带了的 pisum 苜蓿赛跑蚜虫是 R。insecticola。有趣地, endosymbionts 的一篇高度可变的作文由 S 带了。avenae 也在 agroclimatic 地区之间被观察,建议 endosymbionts 正在回答到不能生活的变量(温度和猛冲) 的差别。另外,我们的调查结果在以前没屏蔽的谷物蚜虫种类组成细菌的 endosymbionts 的第一份报告,并且也,第一在智利蚜虫 endosymbionts 报导。 | Daniela A. Sepulvedat Francisca Zepeda-Paulo Claudio C. Ramfrez Bias Lavandero Christian C. Figueroa | 2017 | Insect Science2017，24，3： | 2 |
| 13 | Use of spiral computerized tomography in lieu of angiography for preoperative assessment of living renal donors显示文摘 | KAYAN AM ROZENBLIT AM FIGUEROA KI | 1999 | J Urol1999，161，6： | 1 |
| 14 | Effects of light intensity,CO2 and nitrogen supply on lipid class composition of Dunaliella viridis 显示文摘 | Gordillo F J L Goutx M Figueroa F L | 1998 | Applied Phycology1998，10，： | 1 |
| 15 | Evaluation of amniotic fluid cytokines in preterm labor and intact membranes 显示文摘 | Figueroa R Garry D Elimian A | 2005 | J Matern Fetal Neonatal Med2005，18，3： | 1 |
| 16 | Modeling tetracycline antibiotic sorption to clays显示文摘 | Figueroa R A Leonard A MacKay A A | 2003 | Environmental Science & Technology2003，38，2： | 1 |
| 17 | Expression of voltage-gated potassium channels in human and rhesus pancreatic islets 显示文摘 | LIZHEN YAN DAVID J FIGUEROA CHRISTOPHER P | 2004 | Diabetes2004，，53： | 1 |
| 18 | Gap-junction channelsdysfunction in deafness and hearing loss显示文摘 | Martínez AD Acua R Figueroa V | 2009 | Antioxid Redox Sig-nal2009，11，2： | 1 |
| 19 | Tectonic geomorphology of the southern sierra nevada mountains (California) : evidence for uplift and basin formation显示文摘 | FIGUEROA A M KNOTT J R | 2010 | Geomorphology2010，123，12： | 1 |
| 20 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy显示文摘 | Cerchietti Leandro C Hatzi Katerina Caldas-Lopes Eloisi Yang Shao Ning Figueroa Maria E Morin Ryan D Hirst Martin Mendez Lourdes Shaknovich Rita Cole Philip A Bhalla Kapil Gascoyne Randy D Marra Marco Chiosis Gabriela Melnick Ari | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
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