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| 1 | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma显示文摘Pancreatic cancer(Pa C) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease. | Esther Llop Pedro E Guerrero AdriàDuran Sílvia Barrabés Anna Massaguer María JoséFerri Maite Albiol-Quer Rafael de Llorens Rosa Peracaula | 2018 | World Journal of Gastroenterology2018，24，24： | 4 |
| 2 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 4 |
| 3 | Autoimmune hepatitis in childhood: The role of genetic and immune factors显示文摘Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population. | Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues Ferreira Ana Cristina Simoes e Silva | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 4 | Diagnostic criteria for autoimmune hepatitis in children: A challenge for pediatric hepatologists显示文摘Autoimmune hepatitis (AIH) is a progressive inflammatory liver disorder that is rare in children and adolescents. AIH has a broad clinical spectrum and a quick response to treatment with corticosteroids and immunosuppressive medication. The available diagnosis criteria have limitations and should be evaluated in pediatric populations. Recently, some studies reported that the 2008 simplified diagnostic criteria for AIH could be used in children with high sensibility and specificity. In addition, the authors reported that globulin and immunoglobulin G levels can be used interchangeably for diagnostic purposes. They also demonstrated that the 2008 simplified criteria fail in identifying patients with fulminant hepatic failure. Here, we discuss the limitations of the use of these criteria in pediatric patients and the requirement of more studies to improve the diagnosis of AIH in children. | Priscila Menezes Ferri Alexandre Rodrigues Ferreira Débora Marques Miranda Ana Cristina Sim■es e Silva | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 5 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 2 |
| 6 | Differential Effectiveness of Candidate IM Tactics on Employment Interview Decisions显示文摘 | Kacmar K M Delery J E Ferris G R | 1992 | Journal of Applied Social Psychology1992，22，： | 1 |
| 7 | Adenoviral Delivery of Human and Viral IL-10 in Murine Sepsis显示文摘 | Minter R M Ferry M A Murday M E | 2001 | J Immunol2001，167，： | 1 |
| 8 | Hepatitis C virus infection in patients with non-Hodgkin's lymphoma 显示文摘 | Ferri C Caraciolo E Zignego A | 1994 | Br J Haematol1994，88，： | 1 |
| 9 | Distributed Fault- Tolerance for Event Detection Using Heterogeneous Wireless Sensor Networks 显示文摘 | Ould-Ahmed-Vall E Heck Ferri B Riley G | 2012 | Mobile Computing IEEE Transaction on2012，11，12： | 1 |
| 10 | Displacement-dependent dry friction damping of a beam-like structure显示文摘 | Whiteman W E Ferri A A | 1996 | Journal of Sound and Vibration1996，198，3： | 1 |
| 11 | Fasting and post-methioninehomocysteine levels in Alzheimers disease And vascu]ar dementia显示文摘 | Viiia P Bosco P Ferri E | 2009 | Int J Vitam Nutr ges2009，9，3： | 1 |
| 12 | Terms of engagement: Political boundaries of work engagement-work outcomes relationships 显示文摘 | Kane-Frieder R E Hochwarter W A Ferris G R | 2014 | Human Relations2014，67，3： | 1 |
| 13 | Frequency domain solutions to multi-degree of freedom, dry friction damped systems显示文摘 | Ferri A A McDowell E H | 1988 | J Sound Vib1988，124，2： | 1 |
| 14 | Influence of talc physical properties on the fire retarding behaviour of (ethylenevinyl acetate copolymer/magnesium hydroxide/talc) composites显示文摘 | Clerc L Ferry L Leroy E | 2005 | Polymer Degradation and Stability2005，88，： | 1 |
| 15 | Influence of talc physicalproperties on the fire retarding behaviour of (ethylene-vinyl acetatecopolymer / magnesium hydroxide / talc) composites显示文摘 | Cl ere L Ferry L Leroy E | 2005 | PolymerDegradation and Stability2005，88，3： | 1 |
| 16 | Value of indirect hem agglutination and coagglutiation test for serotyping Haemophilus parasuis显示文摘 | Del Rio M L Gut ierrez B C Rodriguez Ferri E F | 2003 | Clin Microbio 12003，41，2： | 1 |
| 17 | Hypertonic saline resuscitation of hemorrhagic shock diminishes PMN rolling and adherence to endothelium and reduces in vivo vascular leakage显示文摘 | Pascual J L Ferri L E Seely A J | 2002 | Ann Surg2002，236，5： | 1 |
| 18 | The zebrafish bcl-2 homologue Nrz controls development during somitogenesis and gastrulation via apoptosis-dependent and-independent mechanisms显示文摘 | Arnaud E Ferri KF Thibaut J | 2006 | Cell Death Differ2006，13，7： | 1 |
| 19 | Where is my bus? impact of mobile real time information on the perceived and actual waite time of transit riders 显示文摘 | Watkins K E Ferris B Borning A | 2011 | Transportation Research Part A2011，45，： | 1 |
| 20 | Core SelbEvaluations: A Review and Evaluation of the Literature 显示文摘 | FERRIS D L JOHNSON R E ROSEN C C | 2012 | Journal of Management2012，38，1： | 1 |
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