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| 1 | PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13显示文摘脉管的光滑的肌肉房间(VSMC ) 被将生物的活组织移植于培养基中培养方法从男 SpragueDawley 老鼠的胸的主动脉准备经由 3 kinase (PI3K )/Akt 发信号 transduction 小径由 apelin-13 导致了的 phosphoinositide 观察 VSMC 增长。PI3K, phospho-PI3K, phospho-Akt, ERK1/2, phospho-ERK1/2 和 cyclin D1 的表示被西方的污点分析检测。结果证明 apelin-13 在剂量依赖者和时间依赖者举止支持了 phospho-PI3K 和 phospho-Akt 的表示。PI3K 禁止者 LY294002 显著地减少了 phospho-PI3K, phospho-Akt, phospho-ERK1/2,和 cyclin D1 的表示由 apelin-13 导致了。Akt 禁止者 1701-1 显著地减少了 phospho-Akt, phospho-ERK1/2,和 cyclin D1 的表示由 apelin-13 刺激了。MTT 试金结果证明 PI3K 禁止者 LY294002 和 Akt 禁止者 1701-1 显著地禁止了 apelin-13 导致的 VSMC 增长。Apelin-13 通过表明 transduction 小径的 PI3K/Akt 支持了 VSMC 增长。 | Changhui Liu Tao Su Fang Li Lanfang Li Xuping Qin Weinan Pan Fen Feng Feng Chen Duanfang Liao Linxi Chen | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 41 |
| 2 | A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway显示文摘这研究被设计调查 APJ 受体是否在静态的导致压力的 cardiomyocyte hypertrophyand 充当一个传感器调查 PI3K-autophagy 小径的机制。左室的肥大老鼠模型是腹的主动脉的确定的 bycoarctation。H9c2 老鼠 cardiomyocytes 面对被给 bya 的静态的压力是有教养的定做的压力孵卵器。结果表明 apelin/APJ 系统, PI3K, Akt 和他们的 phosphorylationwere 的表达式显著地在操作组增加了。静态的压力起来调整在 cardiomyocytes 的 APJ 表示, PI3K phosphorylation, Akt phosphorylation, LC3-II/I 和 beclin-1 表示。APJ shRNA pGPU6/Neo-rat-399, PI3K 禁止者 LY294002, Akt 禁止者 1701-1 分别地堵住了 APJ, PI3K phosphorylation, Akt phosphorylation, LC3-II/I 和 beclin-1 表示的起来规定。而且,静态的压力增加了直径,体积,房间的蛋白质内容,和这些能是 reversedwhen 房间分别地与 pGPU6/Neo-rat-399, LY294002,和 autophagy 禁止者 3-methyladenine 被对待。Theseresults 建议了那静态的压力起来调整 APJ 表情由 PI3K-autophagypathway 支持 cardiomyocyte 肥大。 | Feng Xiei Wei Liu Fen Feng Xin Li Li Yang Deguan Lv Xuping Qin Lanfang Li Linxi Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 10 |
| 3 | Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy显示文摘Apelin 高度在左室的肥大 Sprague Dawley 老鼠建模的老鼠被表示,并且它在心血管的系统起一个关键作用。这研究是澄清 apelin-13 是否在 H9c2 老鼠 cardiomyocytes 支持肥大并且调查它的内在的机制的目的。cardiomyocyte 肥大被测量 H9c2 房间的直径,体积,和蛋白质内容观察。autophagy 的激活被由传播电子显微镜学观察 autophagosomes 的形态学评估,观察由轻显微镜学的 LC3 的 subcellular 本地化,并且由西方的污点分析检测 LC3 的联系膜的形式。表明小径的 phosphatidylinositol 3-kinase (PI3K ) 被识别,蛋白质表示用西方的污点分析被检测。结果表明 apelin-13 增加了 H9c2 房间的直径,体积,和蛋白质内容并且支持了 PI3K, Akt, ERK1/2,和 p70S6K 的 phosphorylation。Apelin-13 激活 PI3K-Akt-ERK1/2-p70S6K 小径。PI3K 禁止者 LY294002, Akt 禁止者 1701-1, ERK1/2 禁止者 PD98059 稀释了房间直径的增加,体积,蛋白质内容由 apelin-13 导致了。Apelin-13 增加了 autophagosomes 并且起来调整 beclin 的表情 1 并且 LC3-II/I 短暂地并且稳定地。autophagy 禁止者 3MA 改善了被 apelin-13 导致的房间直径,体积,和蛋白质内容的增加。这些结果建议 apelin-13 经由 PI3K-Akt-ERK1/2-p70S6K 和导致 PI3K 的 autophagy 支持 H9c2 老鼠 cardiomyocyte 肥大。 | Feng Xie Wei Liu Fen Feng Xin Li Lu He Deguan Lv Xuping Qin Lifang Li Lanfang Li Linxi Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 9 |
| 4 | Mn3O4 nanoparticles@reduced graphene oxide composite:An efficient electrocatalyst for artificial N2 fixation to NH3 at ambient conditions显示文摘Currently,industrial-scale NH3 production almost relies on energy-intensive Haber-Bosch process from atmospheric N2 with large amount of CO2 emission,while low-cost and high-efficient catalysts are demanded for the N2 reduction reaction (NRR).In this study,Mn3O4 nanoparticles@reduced graphene oxide (Mn3O4@rGO) composite is reported as an efficient NRR electrocatalyst with excellent selectivity for NH3 formation.In 0.1 M Na2SO4 solution,such catalyst obtains a NH3 yield of 17.4 μg·h^-1·mg^-1cat.and a Faradaic efficiency of 3.52% at-0.85 V vs.reversible hydrogen electrode.Notably,it also shows high electrochemical stability during electrolysis process.Density functional theory (DFT) calculations also demonstrate that the (112) planes of Mn3O4 possess superior NRR activity. | Hong Huang Feng Gong Yuan Wang Huanbo Wang Xiufeng Wu Wenbo Lu Runbo Zhao Hongyu Chen Xifeng Shi Abdullah M.Asiri Tingshuai Li Qian Liu Xuping Sun | 2019 | Nano Research2019，12，5： | 8 |
| 5 | Development of Fully-Distributed Fiber Sensors Based on Brillouin Scattering显示文摘Brillouin scattering based optical fiber sensors(BOFS)have the unique advantages over other sensors such as long distance,fully distributed,and multi-parameter sensing.The progresses on the development of BOFS technology in Nanjing University are reviewed.The key technologies to make BOFS with ultra-long distance,high spatial resolution,and fast measuring speed are discussed and realized. | Xuping ZHANG Yuangang LU Feng WANG Hao LIANG Yixin ZHANG | 2011 | Photonic Sensors2011，1，1： | 7 |
| 6 | Co3(hexahydroxytriphenylene)2:A conductive metal-organic framework for ambient electrocatalytic N2 reduction to NH3显示文摘As a carbon-neutral alternative to the Haber-Bosch process,electrochemical N2 reduction enables environment-friendly NH3 synthesis at ambient conditions but needs active electrocatalysts for the N2 reduction reaction.Here,we report that conductive metal-organic framework CO3(hexahydroxytriphenylene)2(Co3 HHTP2)nanoparticles act as an efficient catalyst for ambient electrochemical N2-to-NH3 fixation.When tested in 0.5 M LiClO4,such Co3 HHTP2 achieves a large NH3 yield of 22.14μg·h^-1·mg^-1 cat.with a faradaic efficiency of 3.34%at-0.40 V versus the reversible hydrogen electrode.This catalyst also shows high electrochemical stability and excellent selectivity toward NH3 synthesis. | Wei Xiong Xin Cheng Ting Wang Yongsong Luo Jing Feng Siyu Lu Abdullah M.Asiri Wei Li Zhenju Jiang Xuping Sun | 2020 | Nano Research2020，13，4： | 7 |
| 7 | Active Source Seismic Identification and Automatic Picking of the P-wave First Arrival Using a Convolutional Neural Network显示文摘In seismic data processing,picking of the P-wave first arrivals takes up plenty of time and labor,and its accuracy plays a key role in imaging seismic structures.Based on the convolution neural network(CNN),we propose a new method to pick up the P-wave first arrivals automatically.Emitted from MINI28 vibroseis in the Jingdezhen seismic experiment,the vertical component of seismic waveforms recorded by EPS 32-bit portable seismometers are used for manually picking up the first arrivals(a total of 7242).Based on these arrivals,we establish the training and testing sets,including 25,290 event samples and 710,616 noise samples(length of each sample:2 s).After 3,000 steps of training,we obtain a convergent CNN model,which can automatically classify seismic events and noise samples with high accuracy(>99%).With the trained CNN model,we scan continuous seismic records and take the maximum output(probability of a seismic event)as the P-wave first arrival time.Compared with STA/LTA(short time average/long time average),our method shows higher precision and stronger anti-noise ability,especially with the low SNR seismic data.This CNN method is of great significance for promoting the intellectualization of seismic data processing,improving the resolution of seismic imaging,and promoting the joint inversion of active and passive sources. | XU Zhen WANG Tao XU Shanhui WANG Baoshan FENG Xuping SHI Jing YANG Minghan | 2019 | Earthquake Research in China2019，33，2： | 3 |
| 8 | Significant sensing performance of an all-silicon terahertz metasurface chip for Bacillus thuringiensis Cry1Ac protein显示文摘The promising prospect of a terahertz metasurface in sensing and detection applications has attracted increasing attention because of its ability to overcome the classical diffraction limit and the enhancement of field intensity.In this work,a novel scheme based on an all-silicon terahertz plasmon metasurface is proposed and experimentally demonstrated to be a highly sensitive biosensor for the Bacillus thuringiensis Cry1Ac toxin.The regression coefficients between Bacillus thuringiensis protein concentrations and the spectral resonance intensity and frequency were 0.8988 and 0.9238,respectively.The resonance amplitude variation and frequency shift of the metasurface were investigated in terms of both thickness and permittivity change of the analyte,which reflected the protein residue in the actual process.Moreover,the reliability and stability of the metasurface chip were verified by time period,temperature,and humidity control.These results promise the ability of the proposed metasurface chip as a Bacillus thuringiensis protein sensor with high sensitivity and stability.In addition,this novel device strategy provides opportunities for the advancement of terahertz functional applications in the fields of biochemical sensing and detection. | Zijian Cui Yue Wang Yongqiang Shi Yongqiang Zhu Dachi Zhang Zhiqi Hong Xuping Feng | 2022 | Photonics Research2022，10，3： | 2 |
| 9 | Spontaneous rupture of hepatocellular carcinoma trans-arterial embolization or hepatectomy?显示文摘Spontaneous rupture and hemorrhage of hepatocellular carcinoma(HCC)is one of the serious complications leading to death in patients with primary liver cancer.Approximately 9-10%of those patients with liver cancer die of from spontaneous rupture and hemorrhage,which is often accompanied by abdominal metastasis and seriously affects their prognosis(1). | Qingbo Feng Xiaoyin Liu Xuping Feng Chuwen Chen Jiaxin Li Yong Zeng | 2022 | Hepatobiliary Surgery and Nutrition2022，11，6： | 1 |
| 10 | FeP nanorod array:A high-efficiency catalyst for electroreduction of NO to NH3 under ambient conditions显示文摘Sustainable mitigation of the continuously rising concentration of NO contaminants is among the most urgent issues of this century.Ambient electrocatalytic conversion of NO into useful NH_(3)offers an attractive path toward achieving sustainable NO abatement and NH_(3)production simultaneously.However,its efficiency is challenged by the intense competition from hydrogen evolution reaction and relatively high energy barriers of NO activation.It is thus highly desirable to explore active electrocatalyst for NO reduction reaction and investigate the mechanisms on relevant surfaces.Herein,we introduce an FeP nanorod array on carbon cloth as a high-efficiency catalyst for NO electroreduction to NH3.In 0.2 M phosphate-buffered solution,this catalyst exhibits a low onset potential of-0.014 V.Moreover,it achieves a remarkable Faradaic efficiency of 88.49%and a large NH_(3)yield of 85.62μmol·h^(-1)cm^(-2),with durability for stable NO conversion over 12 h of electrolysis.The catalytic mechanism on FeP is investigated further by theoretical calculations. | Jie Liang Qiang Zhou Ting Mou Hongyu Chen Luchao Yue Yongsong Luo Qian Liu Mohamed S.Hamdy Abdulmohsen Ali Alshehri Feng Gong Xuping Sun | 2022 | Nano Research2022，15，5： | 1 |
| 11 | A Training Set Selection Strategy for a Universal Near Infrared Quanti- tative Model 显示文摘 | Jia Yanhua Liu Xuping Feng Yanchun | 2011 | AAPS PharmSciTech2011，12，2： | 1 |
| 12 | Detection of multiple vibration points using fundamental frequency mad harmonic progressions in response speclra of POTDR显示文摘 | Chen Mengmeng Wang Feng Zhang Xuping | 2013 | Optik -International Journal for Light and Electron Optics2013，124，21： | 1 |
| 13 | Influence of optical pulse width on the perturbation detection performance of polarization-optical time domain reflectometer显示文摘 | Wang Feng Wang Xiangchuan Zhang Xuping | 2012 | Applied Optics2012，51，35： | 1 |
| 14 | Earthquake Disaster Simulation for an Urban Area, with GIS, CAD, FEA, and VR Integration显示文摘 | Feng Xu Xuping Chen Aizhu Ren Xinzheng Lu | 2008 | Tsinghua Science & Technology2008，，： | 1 |
| 15 | Fe-doped Co_(3)O_(4) nanowire strutted 3D pinewood-derived carbon: A highly selective electrocatalyst for ammonia production via nitrate reduction显示文摘Nitrate(NO_(3)^(-)),a nitrogen-containing pollutant,is prevalent in aqueous solutions,contributing to a range of environmental and health-related issues.The electrocatalytic reduction of NO_(3)^(-)holds promise as a sustainable approach to both eliminating NO_(3)^(-)and generating valuable ammonia(NH_(3)).Nevertheless,the reduction reaction of NO_(3)^(-)(NO_(3)^(-)RR),involving 8-electron transfer process,is intricate,necessitating highly efficient electrocatalysts to facilitate the conversion of NO_(3)^(-)to NH_(3).In this study,Fe-doped Co_(3)O_(4) nanowire strutted three-dimensional(3D)pinewood-derived carbon(Fe-Co_(3)O_(4)/PC)is proposed as a high-efficiency NO_(3)^(-)RR electrocatalyst for NH_(3) production.Operating within 0.1 M NaOH containing NO_(3)^(-),Fe-Co_(3)O_(4)/PC demonstrates exceptional performance,obtain an impressively large NH_(3) yield of 0.55 mmol·h^(-1)·cm^(-2) and an exceptionally high Faradaic efficiency of 96.5%at-0.5 V,superior to its Co_(3)O_(4)/PC counterpart(0.2 mmol·h^(-1)·cm^(-2),73.3%).Furthermore,the study delves into the reaction mechanism of Fe-Co_(3)O_(4) for NO_(3)^(-)RR through theoretical calculations. | Xuwei Liu Chaozhen Liu Xun He Zhengwei Cai Kai Dong Jun Li Xiaoya Fan Ting Xie Xiya Yang Yonglan Luo Dongdong Zheng Shengjun Sun Sulaiman Alfaifi Feng Gong Xuping Sun | 2024 | Nano Research2024，17，4： | 0 |
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