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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 3 | Anisotropic damage model under continuum slip crystal plasticity theory for single crystals显示文摘 | Feng L Zhang K S Zhang G Yu H D | 2002 | International Journal of Solids and Structures2002，39，： | 2 |
| 4 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 5 | Studies on solid-solid phase transition of polyols by infrared spectroscopy 显示文摘 | Feng H Y Liu X D He S M | 2000 | Thermochim Acta2000，348，： | 2 |
| 6 | Moving element method for train-track dynamics显示文摘 | Koh C G Ong J S Y Chua D K H Feng J | 2003 | International Journal for Numerical Methods in Engineering2003，56，： | 1 |
| 7 | Preliminary design for a China ITER test blanket module 显示文摘 | Feng K M Pan C H Zhang G S | 2006 | Fusion Engineering and Design2006，81，814： | 1 |
| 8 | Multipesticide residue method for fruits and vegetables:California Department of Food and Agriculture显示文摘 | LEE S M PAPATHAKIS M L FENG H M | 1991 | Fresenius J Anal Chem1991，339，： | 1 |
| 9 | Association between bone loss and promoter polymorphism in the IL-6 gene in elderly Japanese women with hip fracture 显示文摘 | Feng D Ishibashi H Yamamoto S | 2003 | J Bone Miner Metab2003，21，： | 1 |
| 10 | Alpha-amylase inhibition of insect and human alpha-amylases显示文摘 | FENG G H RICHARDSON M CHEN M S | 1996 | Biochem Mol Biol1996，26，： | 1 |
| 11 | Kinetically restraining aggrega- tion of ZnS nanocrystals and the effect on photocatalysis 显示文摘 | Feng S A Zhao J H Zhu Z P | 2008 | Materi- als Science and Engineering: B Solid-State Materials for Ad- vanced Technology2008，150，2： | 1 |
| 12 | One-pot synthesis of donor-acceptor rotaxanes based on cryptand-pa- raquat recognition motif 显示文摘 | Xu Z K Jiang L S Feng Y H | 2011 | Organic & Biomolecular Chemistry2011，9，： | 1 |
| 13 | Changes in micro-RNA profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes显示文摘 | Ling H Y Ou H S Feng S D | | 0，，09： | 1 |
| 14 | Thermomechanical properties of brazed wire-woven bulk Kagome cellular metals for multifunctional applications显示文摘 | FENG S S LI M Z JOO J H | 2012 | Journal of Thermophysics and Heat Transfer2012，26，1： | 1 |
| 15 | Improving availability of RAID structured storage systems by workload outsourcing显示文摘 | Wu S Jiang H Feng D | 2011 | IEEE Transactions on Computers2011，60，1： | 1 |
| 16 | Effect of Bi203 on physical, optical and structural properties of boron silicon bismuthate glasses 显示文摘 | GAO G HU L L FAN H Y WANG G N LI K F FENG S Y FAN S J CHEN H Y | 2009 | Optical Materials2009，32，： | 1 |
| 17 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 18 | Fragility analysis of bridges under ground motion with spatial variation显示文摘 | Kim S H Feng M Q | 2003 | International Journal of Non-lineas Mechanics2003，38，： | 1 |
| 19 | A Soft Chemistry Route for the Synthesis of Nano Solid Electrolytes (CeO2)1-xBixO2-x/2 显示文摘 | FENG S H XU W | 2000 | Materials Research Bulletin2000，，35： | 1 |
| 20 | Ambient salinity modulates the expression of sodium pumps in branchial mitochondria-fich cells of Mozambique tilapia,Oreochromis mossambicus 显示文摘 | LEE T H FENG S HILIN C H | | Zool Sci0，20，： | 1 |
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