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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 3 | Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis显示文摘 | Palendira U Kamath A T Feng C G | | Infect Immun0，20，： | 2 |
| 4 | Influence of PbF2 doping on scintillation properties of PbWO4 single crystals显示文摘 | Liu X C Feng X Q Hu G Q | 2002 | Phys Status Solidi (A)2002，190，1： | 2 |
| 5 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 6 | Moving element method for train-track dynamics显示文摘 | Koh C G Ong J S Y Chua D K H Feng J | 2003 | International Journal for Numerical Methods in Engineering2003，56，： | 1 |
| 7 | Co-occurrence of magnetic and structural transitions in the Heusler alloy Ni53Mn25Ga22显示文摘 | Jiang C B Feng G Xu H B | 2002 | Applied Physics Letters2002，80，9： | 1 |
| 8 | Preliminary design for a China ITER test blanket module 显示文摘 | Feng K M Pan C H Zhang G S | 2006 | Fusion Engineering and Design2006，81，814： | 1 |
| 9 | The structural and magnetic properties of Mn2 xFexNiGa Heusler alloys显示文摘 | LUO H Z MENG F B FENG Z Q LI Y X ZHU W WU G H ZHU X X JIANG C B XU H B | 2010 | J Appl Phys2010，107，01： | 1 |
| 10 | Ki67 and TP53 expressions predict recurrence of non-muscle-invasive bladder cancer 显示文摘 | Wang L Feng C Ding G | 2014 | Tumour Biot2014，35，4： | 1 |
| 11 | The effect of lead exposure on brain iron homeostasis and the expression of DMT1/FP1 in the brain in developing and aged rats显示文摘 | Zhu G Fan G Feng C | 2013 | Toxicol Lett2013，216，23： | 1 |
| 12 | Selection of nutrients for prevention or amelioration of lead-induced learning and memory impairment in rats显示文摘 | Fan G Feng C Li Y | 2009 | Ann Occup Hyg2009，53，4： | 1 |
| 13 | The biology of Ku and its potential oncogenic role in cancer显示文摘 | Gullo C Au M Feng G | 2006 | Biochim Biophys Acta2006，1765，2： | 1 |
| 14 | Priming by DNA immunization augments protective efficacy of Mycobacterium bovis bacille Calmette - Guerin against tuberculosis 显示文摘 | Feng C G alendira U Demangel C | 2001 | Ini-ction and Immunity2001，69，6： | 1 |
| 15 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small cell lung cancer (OPTIMAL, CTONG-0802):a multicentre open-label, randomised, phase 3 study显示文摘 | Zhou C Wu Y L Chen G Y Feng J Liu X Q Wang C | 2011 | Lancet Oncol2011，12，： | 1 |
| 16 | 查看详情显示文摘 | Feng M G Chen C Chen B | | 0，，： | 1 |
| 17 | Relationship of TP53 and Ki67 expression in bladder cancer under WHO 2004 classification 显示文摘 | Wang L Feng C Ding G | 2013 | J BUON2013，18，2： | 1 |
| 18 | Treatment of three- and four-part proximal humeral fractures with locking proximal humerus plate显示文摘 | Sun J C Li Y L Ning G Z Wu Q Feng S Q | 2013 | Eur J Orthop Surg Traumatol2013，23，： | 1 |
| 19 | Synthesis and characterization of PVC/Montmorillonite nanocomposite显示文摘 | F L GONG C G ZHAO M FENG | 2004 | Materials Science2004，，39： | 1 |
| 20 | TLR9 regulates Thl re- sponses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis 显示文摘 | Bafica A Scanga C A Feng C G | 2005 | J Exp Med2005，202，12： | 1 |
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