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| 1 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 2 | Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and Bcl-2 during left ventricular adaptations to chronic pressure overload in the rat显示文摘 | Gianluigi C Carmine M Giorgio S Antonella N Felicia F Giuseppe S | 1999 | Circulation1999，99，： | 1 |
| 3 | Prediction of T-cell epitopes using biosupport vector machines显示文摘 | Zheng R Y Felicia C J | 2005 | J Chem lnfModel2005，45，： | 1 |
| 4 | Coal mine methane:a review ofcapture and utilization practices with benefits to mining safety and togreenhouse gas reduction greenhouse gas reduction显示文摘 | Ozgen Karacan C Felicia A Ruiz | 2011 | InternationalJournal of Coal Geology2011，86，： | 1 |
| 5 | Prediction of T-Cell epitopes using biosupport vector machines显示文摘 | Yang Z R Felicia C J | 2005 | J Chem Inf Model2005，45，5： | 1 |
| 6 | Anatomical study of variations in the blood supply of kidneys显示文摘 | Aristotle S Sundarapandian Felicia C | 2013 | J Clin Diagn Res2013，7，8： | 1 |
| 7 | Genetic linkage mapping of zebrafish genes and ESTs 显示文摘 | Peter DK Felicia C Ian GW | 2000 | Gen Res2000，10，： | 1 |
| 8 | Coal mine methane:A review of capture and utilization practices with benefits to mining safety and to greenhouse gas reduction 显示文摘 | C Ozgen Karacan Felicia A Ruiz Michael Cote | 2011 | In- ternational Journal of Coal Geology2011，86，23： | 1 |
| 9 | A 3-D dielectro phoretic filter chip显示文摘 | CIPRIAN I XU G L FELICIA C | 2007 | Electrophoresis2007，28，7： | 1 |
| 10 | Montoya Finite Element Modeling of Wind Turbine Blades显示文摘 | Daniel L Laid Felicia C | 2005 | 43rd AIAA Aerospace Sciences Meeting and Exhibit2005，，6： | 1 |
| 11 | Variability in anticancer lignan levels in flaxseed 显示文摘 | LILIAN U T SHARON E R FELICIA C | 1997 | Nutr Cancer1997，27，1： | 1 |
| 12 | Nocturnal blood pressure fall as predictor of diabetic nephropathy in hypertensive patients with type 2 diabetes显示文摘 | Felicia J S de Souza A C Kohlmann N | 2010 | Cardiovasc Diabetol2010，9，12： | 1 |
| 13 | 儿童期哮喘病史与青年期无症状动脉硬化的关系:Bogalusa心脏研究显示文摘哮喘与各种心血管病风险相关。目前尚不清楚儿童期哮喘病史是否会导致成年动脉硬化(心血管事件的一种无创性替代指标)。为此,Dianjianyi对年龄20~51岁有儿童期哮喘病史的Bogalusa心脏研究参与者1746人进行前瞻性分析。 | 刘青 叶鹏 Dianjianyi S Xiang L Yoriko H Hoirun N Xiaoyun S Felicia R Tanika K Emily H Shengxu L Jiang H Lydia B Wei C Lu Q | 2018 | 中华高血压杂志2018，26，6： | 0 |
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