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| 1 | Iron and liver fibrosis: Mechanistic and clinical aspects显示文摘Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts normal liver functionality. It is a pathological stage in several untreated chronic liver diseases such as the iron overload syndrome hereditary haemochromatosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and diabetes. Interestingly, regardless of the aetiology, iron-loading is frequently observed in chronic liver diseases. Excess iron can feed the Fenton reaction to generate unquenchable amounts of free radicals that cause grave cellular and tissue damage and thereby contribute to fibrosis. Moreover, excess iron can induce fibrosis-promoting signals in the parenchymal and non-parenchymal cells, which accelerate disease progression and exacerbate liver pathology. Fibrosis regression is achievable following treatment, but if untreated or unsuccessful, it can progress to the irreversible cirrhotic stage leading to organ failure and hepatocellular carcinoma, where resection or transplantation remain the only curative options. Therefore,understanding the role of iron in liver fibrosis is extremely essential as it can help in formulating iron-related diagnostic, prognostic and treatment strategies. These can be implemented in isolation or in combination with the current approaches to prepone detection, and halt or decelerate fibrosis progression before it reaches the irreparable stage. Thus, this review narrates the role of iron in liver fibrosis. It examines the underlying mechanisms by which excess iron can facilitate fibrotic responses. It describes the role of iron in various clinical pathologies and lastly,highlights the significance and potential of iron-related proteins in the diagnosis and therapeutics of liver fibrosis. | Kosha J Mehta Sebastien Je Farnaud Paul A Sharp | 2019 | World Journal of Gastroenterology2019，25，5： | 39 |
| 2 | Lactoferrin-a muLtifunctionaL protein with antimicrobial properties显示文摘 | Sebbastien Farnaud Robert W Evans | 2003 | Molecular Immunology2003，40，： | 1 |
| 3 | Hepatocyte growth factor (HGF/SF) is expressed in human epithelial cells during embryonic development, studies by in situ hybridisation and northern blot analysis显示文摘 | Wang Y Selden C Farnaud S | 1994 | J Anat1994，185，： | 1 |
| 4 | Lactoferrin: a multifunctional protein with antimicrobial properties显示文摘 | FARNAUD S EVANS R W | 2003 | Molecular Immunology2003，40，： | 1 |
| 5 | Lactoferrin-a multifunctional protein with antimicrobial properties显示文摘 | Evans R W | 2003 | Mol Immunol2003，40，7： | 1 |
| 6 | Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity显示文摘 | Farnaud S Spiller C Moriarty L C | 2004 | FEMS Microbiol Lett2004，233，： | 1 |
| 7 | Lactoferrin a multifunctional protein with antimicrobial properties显示文摘 | Farnaud S Evans R W | 2003 | Mol Immunol2003，40，7： | 1 |
| 8 | Lactoferrin-a rnultifunctional protein with antimicrobial properties 显示文摘 | Farnaud S Evans R W | 2003 | Molecular Immunology2003，40，7： | 1 |
| 9 | Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity显示文摘 | Farnaud S Spiller C Moriarty LC | 2004 | FEMS Microbiol Lett2004，233，： | 1 |
| 10 | Laetoferrin-a multifunctional protein with antimicrobial properties显示文摘 | Farnaud S Evans RW | 2003 | Mol Immunol2003，40，7： | 1 |
| 11 | Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae显示文摘 | Peter J. Sargent Sebastien Farnaud Richard Cammack Heinz M. P. Zoller Robert W. Evans | 2006 | BioMetals2006，，5： | 1 |
| 12 | Evans,Lactoferrin-a multifunctional protein with antimicrobial properties显示文摘 | FARNAUD S R W | | 0，，07： | 1 |
| 13 | Lactoferrin--a multifunctional protein with antimicrobial properties 显示文摘 | Farnaud S Evans KW | 2003 | Mol Immunol2003，40，7： | 1 |
| 14 | Lactoferrin-a multifunctional protein with antimierobial properties 显示文摘 | Farnaud S Evans R W | 2003 | Molecular Immunology2003，40，7： | 1 |
| 15 | Lactoferrin: a multifunctional protein with antimicrobial properties显示文摘 | FARNAUD S EVANS R W | 2003 | Mol Immunol2003，40，7： | 1 |
| 16 | Saliva: physiology and diagnostic potential in health and disease显示文摘 | Farnaud SJ Kosti O Getting SJ | 2010 | Scientific World Journal2010，10，： | 1 |
| 17 | Lactoferrin -A multifunctional protein with antimicrubial properties显示文摘 | Farnaud S Evans R W | 2003 | Molecular Immunology2003，40，7： | 1 |
| 18 | Structure/function o- verview of proteins involved in iron storage and transport 显示文摘 | Sargent PJ Farnaud S Evans RW | 2005 | Curr Med Chem2005，12，2： | 1 |
| 19 | Lactoferrin-a multifunctional protein with antimicrobial properties 显示文摘 | Farnaud S Evans RW | 2003 | Molecular Immunology2003，40，7： | 1 |
| 20 | Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modeling显示文摘 | FARNAUD S PATEL A ODELL E W | 2004 | FEMS Microbiology Letters2004，238，1： | 1 |
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