|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in hepatitis C virus/human immunodeficiency virus co-infected patients显示文摘AIM To evaluate the safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in patients with hepatitis C virus(HCV)/human immunodeficiency virus(HIV) co-infection in an urban HIV clinic.METHODS A retrospective cohort study of 40 subjects co-infected with HIV-1 and HCV treated with the fixed-dose combination of ledipasvir and sofosbuvir for 12 wk from 2014 to 2016.All patients included were receiving antiretroviral therapy(ART) with HIV RNA values of 100 copies/m L or fewer regardless of baseline HCV RNA level.The primary end point was a sustained virologic response of HCV at 12 wk(SVR12) after the end of therapy.RESULTS Of the 40 patients enrolled,55% were black,22.5% had been previously treated for HCV,and 25% hadcirrhosis.The patients were on a wide range of ART.Overall,39 patients(97.5%) had a SVR 12 after the end of therapy,including rates of 97.1% in patients with HCV genotype 1 a and 100% in those with HCV genotype 1 b.One patient with HCV genotype 3 a was included and achieved SVR12.Rates of SVR12 were similar regardless of previous treatment or the presence of compensated cirrhosis.Only 1 patient experienced relapse at week 12 following treatment and deep sequencing didn't reveal any resistance associated mutation in the NS5A or NS5B region.Interestingly,7(17.5%) patients who were adherent to ART experienced HIV viral breakthrough which resolved after continuing the same ART regimen.Two(5%) patients experienced HIV-1 virologic rebound due to noncompliance with HIV therapy,which resolved after resuming the same ART regimen.No severe adverse events were observed and no patient discontinued treatment because of adverse events.The most common adverse events included headache(12.5%),fatigue(10%),and diarrhea(2.5%).CONCLUSION This retrospective study demonstrated the high rates of SVR12 of ledipasvir/sofosbuvir on HCV eradication in patients co-infected with HCV and HIV,regardless of HCV baseline levels,HCV treatment history or cirrhosis condition.The oral combination of ledipasvir/sofosbuvir represents a safe and well tolerated HCV treatment option that does not require modification for many of the common HIV ART.Occasional HIV virologic rebound occurred but later resolved without the need to change ART. | Xiaoping He Lynne Hopkins George Everett Willie M Carter Cynthia SchroppDyce Khalid Abusaada Vincent Hsu | 2017 | World Journal of Hepatology2017，9，30： | 2 |
| 2 | Designing flexible manipulators with the lowest natural frequency nearly in- dependent of position 显示文摘 | Everett L J Tang J Compere M | 1999 | IEEE Transactions on Robotics and Automation1999，15，4： | 1 |
| 3 | Reducing the number of unknowns in a constrained minimization problem-an applicationto material balances显示文摘 | Simpson D E Everett M G | 1988 | Appl Math Modelling1988，，： | 1 |
| 4 | Dimensions of Parasocial Interaction by Letter-writers to a Popular Entertainment-education Soap Opera in India 显示文摘 | Sood Suruchi^Rogers Everett M | 2000 | Journal of Broadcasting & Electronic Media2000，，： | 1 |
| 5 | Expression of CPI - 17 and myosin phosphatase correlates with Ca^2+ sensitivity of protein kinase C - induced contraction in rabbit smooth muscle 显示文摘 | Woodsome T P Eto M Everett A | 2001 | J Physiol2001，535，2： | 1 |
| 6 | A randomized clinical trial of progressive addition lenses versus single vision lenses on the progression of myopia in chil-dren显示文摘 | Gwiazda J Hyman L Hussein M Everett D Norton TT Kurtz D | 2003 | Invest Ophthalmol Vis Sciy2003，44，4： | 1 |
| 7 | Short course of omeprazole: a better first diagnostic approach to noncardiac chest pain than endoscopy, manometry, or 24-hour esophageal pH monitoring 显示文摘 | Pandak W M Arezo S Everett S | 2002 | J Clin Gastroenterol2002，35，4： | 1 |
| 8 | Angiographic-guided embolization of metastatic invasive mole显示文摘 | Method MW Hirschfield M Everette HE | 1996 | Gynecol Oncol1996，61，3： | 1 |
| 9 | Knowledge Ransfer Within Japanese Multinationals:Building a Theory显示文摘 | Pavel Strach Andre M Everett | 2006 | Journal of Knowledge Management2006，，4： | 1 |
| 10 | A comparative study of heavy metal concentration and distribution in deposited street dusts in a large and a small urban area: Birmingham and Coventry, West Midlands, UK 显示文摘 | Charlesworth S Everett M McCarthy R | 2003 | Environ Int2003，29，5： | 1 |
| 11 | Models of core/periphery struc- tures 显示文摘 | Borgatti S P Everett M G | 1999 | Social Networks1999，21，4： | 1 |
| 12 | Delayed consecutive exotropia following 7-milimeter bilateral medial rectus recssion for congenital esotropia显示文摘 | Stager DR Weakley DR Jr Everette M | 1994 | J Pediatr Ophthalmol Strabismus1994，31，3： | 1 |
| 13 | An Assessment of Uhra-capacitors as the Power Cache in Toyata THS- H, GM-Allision AHS-2 and Ford FHS Hybrid Propulsion Systems 显示文摘 | John M Miller Michael Everett | 2005 | IEEE2005，，05： | 1 |
| 14 | A concept for a hybrid solar water purification and photovohaic system 显示文摘 | Vivar M Skryabin I Everett V A | 2010 | Solar Energy Materials and Solar Cells2010，94，10： | 1 |
| 15 | Angiographic-guided embolization of metastatic invasive mole 显示文摘 | Method MW Hirschfield M Everette HE | 1996 | Gynecol Oncol1996，61，3： | 1 |
| 16 | Short Course of Omeprazole: a Better First Diagnostic Approach to Noncardiac Chest Pain than Endoscopy, Manometry, or 24 Hour Esophageal pH Monitoring显示文摘 | Pandak W M Arezo S Everett S | 2002 | J Clin Gastroenterol2002，35，4： | 1 |
| 17 | A comparative study of heavy metal concentration and distribution in deposited street dusts in a large and a small urban area: Birmingham and Coventry, West Midlands, UK 显示文摘 | Charlesworth S Everett M McCarthy R | 2003 | Environment International2003，29，5： | 1 |
| 18 | Non-invasive diagnosis of early caries with polarization sensitive optical coherence tomography显示文摘 | Everett M Colston B W Sathyam U S | 1999 | SPIE1999，3593，： | 1 |
| 19 | Threedimensional reconstruction of tetraploid-diploid chimaereic mouse balstocysts 显示文摘 | EVERETT C A STARK M H WEST J D | 2000 | J Anat2000，196，3： | 1 |
| 20 | A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein 显示文摘 | Everett RD Meredith M Orr A | 1997 | The EMBO Journal1997，16，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员