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| 1 | Successful use of adalimumab for treating fistulizing Crohn's disease with pyoderma gangrenosum:Two birds with one stone显示文摘Crohn's disease(CD) is a chronic relapsing and remitting autoinflammatory disorder of the gastrointestinal tract that has many intestinal and extraintestinal complications.The purpose of treatment is long-term remission,reduction of complications,and improvement of patients' quality of life.In many cases,this can be quite challenging and it is necessary to have a well thought out management strategy.We present the case of a 38-year-old woman with fistulizing CD that manifested as diffuse abdominal pain and bloody diarrhea accompanied by arthralgia.In addition,there were ulcerative lesions surrounded by cutaneous inflammation and erythema on her extremities,indicative of pyoderma gangrenosum.The patient was treated with high doses of parenteral methylprednisolone without any improvement and was started on adalimumab.A positive response to adalimumab therapy was observed:after 2 mo of therapy,the ulcerative skin lesion healed completely and the enterogastric fistula was closed after 5 mo adalimumab treatment.Adalimumab might be a suitable initial as well as maintenance therapy in patients with complicated CD. | Eva Zold Arpad Nagy Katalin Devenyi Margit Zeher Zsolt Barta | 2009 | World Journal of Gastroenterology2009，15，18： | 4 |
| 2 | Vitamin D deficiency in undifferentiated connective tissue disease显示文摘 | Eva Zold Peter Szodoray Janos Gaal | 2008 | Arthritis Res Ther2008，10，5： | 1 |
| 3 | Vitamin D deficiency in undifferentiated connective tissue disease 显示文摘 | Eva Zold Peter Szedoray Janos Gaal | 2008 | Arthritis Res Ther2008，10，5： | 1 |
| 4 | Vitamin D deficiency in undifferentiated connective tissue disease 显示文摘 | Eva Zold Peter Szodoray Janos Gaal | 2008 | Arthritis Res Ther2008，10，5： | 1 |
| 5 | Celiac disease and microscopic colitis:A report of 4 cases显示文摘Celiac disease (CD) is an autoimmune disorder of the small intestine that occurs in genetically predisposed people at all ages.However,it can be associated also to other immunopathological disorders,and may be associated with abnormal histology in segments of the gut other than the small bowel including colonic inflammation.While guidelines for endoscopic investigation of the jejunum are well defined,no indication is defined for colonic investigation.We describe four cases of concurrent CD and microscopic colitis (MC) diagnosed at our department over a 10-year period and analyzed the main features and outcomes of CD in this setting.The symptoms of these patients were improved initially by a gluten-free diet before the onset of MC symptoms.Two of the patients were siblings and had an atypical form of CD.The other two patients with CD and MC also presented with fibrosing alveolitis and were anti-Saccharomyces cerevisiae antibody positive.The co-existence of immune-mediated small bowel and colonic inflammatory and pulmonary diseases are not well-known,and no systematic approach has been used to identify the lifelong patterns of these immune-based diseases.Patients can develop,or present with CD at any stage in life,which can co-exist with other gastrointestinal diseases of (auto-) immune origin.In addition,the fa-milial co-existence and prevalence of MC in patients with a prior diagnosis of CD are unclear.Clinicians managing celiac disease should be aware of these associations and understand when to consider colon investigation. | Zsolt Barta Eva Zold Arpad Nagy Margit Zeher Istvan Csipo | 2011 | World Journal of Gastroenterology2011，17，16： | 0 |
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