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| 1 | drug-induced autoimmune liver disease:a diagnostic dilemma of an increasingly reported disease显示文摘The aetiology of autoimmune hepatitis(AIH) is uncer-tain but the disease can be triggered in susceptible patients by external factors such as viruses or drugs.AIH usually develops in individuals with a genetic back-ground mainly consisting of some risk alleles of the major histocompatibility complex(HLA).Many drugs have been linked to AIH phenotypes,which sometimes persist after drug discontinuation,suggesting that they awaken latent autoimmunity.At least three clini-cal scenarios have been proposed that refers to drug- induced autoimmune liver disease(DIAILD):AIH with drug-induced liver injury(DILI); drug induced-AIH(DI-AIH); and immune mediated DILI(IM-DILI).In addi-tion,there are instances showing mixed features of DI-AIH and IM-DILI,as well as DILI cases with positive autoantibodies.Histologically distinguishing DILI from AIH remains a challenge.Even more challenging is the differentiation of AIH from DI-AIH mainly relying in histological features; however,a detailed standard-ised histologic evaluation of large cohorts of AIH and DI-AIH patients would probably render more subtle features that could be of help in the differential diag-nosis between both entities.Growing information on the relationship of drugs and AIH is being available,being drugs like statins and biologic agents more fre-quently involved in cases of DIAILD.In addition,there is some evidence on the fact that patients diagnosed with DIAILD may have had a previous episode of hepa-totoxicity.Further collaborative studies in DIAILD will strengthen the knowledge and understanding of this intriguing and complex disorder which might represent different phenotypes across the spectrum of | Agustin Castiella Eva Zapata M Isabel Lucena Raúl J Andrade | 2014 | World Journal of Hepatology2014，6，4： | 13 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | l -Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer显示文摘 | Sílvia Busquets Roberto Serpe Míriam Toledo Angélica Betancourt Enrica Marmonti Marcel Orpí Fabrizio Pin Eva Capdevila Clelia Madeddu Francisco J. López-Soriano Giovanni Mantovani Antonio Macciò Josep M. Argilés | 2012 | Clinical Nutrition2012，，6： | 2 |
| 4 | Alphali- poic acid is e{fective in prevention and treatment of experimental autoimmune encephalomyelitis显示文摘 | Morini M Roccatagliata L Dell Eva R | 2004 | Journal of Euroirnmunology2004，148，12： | 1 |
| 5 | Synthesis and immunomodulating activity of new amino acid derivatives of glycyrrhizic acid and its methyl ester显示文摘 | Baltina L A Vasil' eva E V | 2004 | Bioorg Khim2004，30，2： | 1 |
| 6 | Mortality attributable totobacco use in Canada and its regions,1998显示文摘 | Makomaski L Eva M Kaiserman MJ | 2004 | Can J PublicHealth2004，95，1： | 1 |
| 7 | Osteoporosis in ankytosing spondylitis - prevalence, risk factors and methods of assessment 显示文摘 | Eva K Mattias L Dan M | 2012 | Arthritis Res Ther2012，14，3： | 1 |
| 8 | Granulocyte Macrophage Colony Stimulation and Steer Factor Induce Phosphorylation of both Unique and Overlapping Signal Transduction Intermediastes in a Human Factor Dependent Hematopoietic Cell Line显示文摘 | Michee H Brain D Eva M L | 1992 | Cell Physiol1992，153，227： | 1 |
| 9 | Placing Food Color Experimentation into a Valid Consumer Context显示文摘 | Lawrence L Garber Eva M Hyatt Richard G Starr | 2001 | Journal of Food Products Marketing2001，7，3： | 1 |
| 10 | Failed res-cue therapy with rapamycin after paraquat intoxication显示文摘 | JOHAN M L EVA S CARSTEN H | 2010 | Clinical Toxicology2010，48，： | 1 |
| 11 | Trends in the Structure and Bonding of Noble Metal Clusters 显示文摘 | Eva M F Jose M S M Ignacio L G | 2004 | Phys Rev B2004，70，16： | 1 |
| 12 | A new method to make dye-sensitized nanocrystalline solar cells at room temperature显示文摘 | ANNA H EVA M | 2001 | Journal of Photochemistry and Photobiology A:Chemistry2001，145，： | 1 |
| 13 | Vaccines against cervical cancer显示文摘 | Rogers L J Eva L J Luesley D M | 2008 | Curr Opin Oncol2008，20，5： | 1 |
| 14 | Changes in contrast thresholds with mean Luminance for chromatic and luminance gratings: A re-examin- ation of the transition fi'om the DeVries-Rose to Weber regions 显示文摘 | Eva M V Juan L N Jose A G | 2004 | Colour research and application2004，29，3： | 1 |
| 15 | GLP-2 Administration Results in Increased Proliferation but Paradoxically an Adverse Outcome in a Juvenile Piglet Model of Short Bowel Syndrome显示文摘 | Prue M Pereira-Fantini Eva S Nagy Sarah L Thomas Russell G Taylor Magdy Sourial Monique CJ Paris Jens J Holst Peter J Fuller Julie E Bines | 2008 | Journal of Pediatric Gastroenterology and Nutrition2008，，1： | 1 |
| 16 | A review of bioohars ' potential role in the remediation,revegeta-tion and restoration of contaminated soils 显示文摘 | Luke B Eduardo M J Jose L G Eva H Brett R Tom S | 2011 | Environmental Pollution2011，，159： | 1 |
| 17 | Scintigraphic Assessment of Regionalized Defects in Myocardial Sympathetic Innervation and Blood Flow Regulation in Diabetic Patients With Autonomic Neuropathy显示文摘 | Martin J Stevens Firat Dayanikli David M Raffel Kevin C Allman Tracy Sandford Eva L Feldman Donald M Wieland James Corbett Marcus Schwaiger | 1998 | Journal of the American College of Cardiology1998，，7： | 1 |
| 18 | Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis显示文摘 | Morini M Roccatagliata L Dell Eva R | 2004 | Neuroimmunol2004，148，2： | 1 |
| 19 | The development and current status of perennial rhizomatous grasses as energy crops in the US and Europe显示文摘 | Iris L Jonathan M O S Eva L | 2003 | Biomass and Bioenergy2003，25，： | 1 |
| 20 | Early results of stent-grafting to treat diffuse aortoiliac occlusive disease显示文摘 | Eva M Rzucidlo Richard J Powell Robert M Zwolak Mark F Fillinger Daniel B Walsh Marc L Schermerhorn Jack L Cronenwett | 2003 | Journal of Vascular Surgery2003，，6： | 1 |
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