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| 1 | Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization显示文摘甾醇规章的元素绑定蛋白质(SREBP ) 抄写因素是在哺乳动物和在真菌的 hypoxic 改编的氧应答的管理者的细胞的类脂化合物动态平衡的主人管理者。SREBP C 终点绑在 SREBP 激活劈开的蛋白质(SCAP ) 的 WD40 领域,它由在 Golgi 控制到激活的朊酶的 SREBP-SCAP 建筑群和存取的 ER-to-Golgi 运输授与甾醇规定。这里,我们生物化学地并且在结构上表演 Sre1 和 Scp1,分裂酵母 SREBP 和 SCAP 的 carboxyl 终端域(CTD ) ,形成功能的 4:4 oligomer 和 Sre1-CTD 形式一 dimers 更暗淡。在 3.5 Å 的 Sre1-CTD 的水晶结构;并且在 5.4 Å 的建筑群的 cryo 他们结构;和在 vitro 生物化学的证据阐明在为 Scp1 绑定, Sre1-CTD dimerization 和 tetrameric 要求的 Sre1-CTD 的三个不同区域形成。最后,这些在结构上鉴别领域在细胞的上下文被验证,证明合适的 4:4 oligomeric 建筑群形成为 Sre1 激活被要求。 | Xin Gong Hongwu Qian Wei Shao Jingxian Li Jianping Wu Jun-Jie Liu Wenqi Li Hong-Wei Wang Peter Espenshade Nieng Yan | 2016 | Cell Research2016，26，11： | 6 |
| 2 | Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition显示文摘 | Xin Gong Jingxian Li Wei Shao Jianping Wu Hongwu Qian Ruobing Ren Peter Espenshade Nieng Yan | 2015 | Cell Research2015，25，4： | 3 |
| 3 | SREBPs:sterol-regulated transcription factors显示文摘 | Espenshade P J | 2006 | J Cell Sci2006，119，6： | 1 |
| 4 | Regulation of ste- rol synthesis in eukaryotes 显示文摘 | ESPENSHADE P J HUGHES A L | 2007 | Genetics2007，41，： | 1 |
| 5 | Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast显示文摘 | Hughes BT Nwosu CC Espenshade PJ | 2009 | J Biol Chem2009，284，20： | 1 |
| 6 | SREBPs: sterol-regulated transcription factors显示文摘 | Espenshade PJ | 2006 | J Cell8012006，119，6： | 1 |
| 7 | Regulation of lipid metabolism:a tale of two yeasts显示文摘 | Raychaudhuri S Young B P Espenshade P J Loewen C J | | 0，，04： | 1 |
| 8 | Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins显示文摘 | Espenshade PJ Cheng D Goldstein JL | | 0，，32： | 1 |
| 9 | Crucial step in cholesterol homeostasis:Sterols promote binding of SCAP to INSIG-1,a membrane protein that facilitates retention of SREBPs in ER显示文摘 | Yang T Espenshade P J Wright M E | | 0，，04： | 1 |
| 10 | Regulation of HMG-CoA reductase in mammals and yeast显示文摘 | John S. Burg Peter J. Espenshade | 2011 | Progress in Lipid Research2011，，4： | 1 |
| 11 | Eosinophilfibroblast interactions induce fibroblast IL-6 secretion and extracellular matrix gene expression:implications in fibrogenesis显示文摘 | Gomes I Mathur SK Espenshade BM | 2005 | J Allergy Clin Immunol2005，116，1： | 1 |
| 12 | Crucial step in cholesterol homeostasis, sterols promote binding of SCAP to INSIG-1,a membrane protein that facilitates retention of SREBPs in ER显示文摘 | YANG T ESPENSHADE P WRIGHT M | 2000 | Cell2000，，110： | 1 |
| 13 | Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been 显示文摘 | Osborne TF Espenshade PJ | 2009 | Genes DEV2009，23，22： | 1 |
| 14 | Crucial Step in Cholesterol Homeostasis显示文摘 | Tong Yang Peter J. Espenshade Michael E. Wright Daisuke Yabe Yi Gong Ruedi Aebersold Joseph L. Goldstein Michael S. Brown | 2002 | Cell2002，，4： | 1 |
| 15 | SREBPs: sterol-regulated transcription factors 显示文摘 | Espenshade P J | 2006 | J Cell Sei2006，119，6： | 1 |
| 16 | Crucial step in choles- terol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER显示文摘 | Yang T Espenshade PJ Wright ME | 2002 | Cell2002，110，4： | 1 |
| 17 | Immigration and the Stable Population Theory 显示文摘 | Espenshade T J Bouvier L F Arthur B W | 1982 | Demography1982，19，1： | 1 |
| 18 | Sterols block binding of COPII proteins to SCAP,thereby controlling SCAP sorting in ER显示文摘 | Espenshade PJ Li WP Yabe D | 2002 | Proc Natl Acad Sci U S A2002，99，11： | 1 |
| 19 | Self-Efficacy, Stress, and Academic Success in College显示文摘 | Anna Zajacova Scott M. Lynch Thomas J. Espenshade | 2005 | Research in Higher Education2005，，6： | 1 |
| 20 | SREBPs: sterol- regulated transcription factors 显示文摘 | Espenshade PJ | 2006 | J Cell Sci2006，119，： | 1 |
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