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| 1 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 2 | A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China显示文摘Matrix metalloproteinase 2(MMP2) has been shown to play an important role in several steps of cancer development.The-1306C/T polymorphism of the MMP2 gene displays a strikingly lower promoter activity than the T allele,and the CC genotype in the MMP2 promoter has been reported to associate with the development of several cancers.To assess the contribution of the MMP2-1306C/T polymorphism to the risk of nasopharyngeal carcinoma(NPC),we conducted a case-control study and analyzed MMP2 genotypes in 370 patients with NPC and 390 frequency-matched controls using real-time PCR-based TaqMan allele analysis.We found that subjects with the CC genotype had an increased risk(OR = 1.55,95% CI = 1.05-2.27) of developing NPC compared to those with the CT or TT genotypes.Furthermore,we found that the risk of NPC was markedly increased in subjects who were smokers(OR = 15.04,95% CI = 6.65-33.99),heavy smokers who smoked ≥20 pack-years(OR = 18.66,95% CI = 7.67-45.38),or young(<60 years) at diagnosis(OR = 1.52,95% CI = 1.01-2.29).Our results provide molecular epidemiological evidence that the MMP2-1306C/T promoter polymorphism is associated with NPC risk,and this association is especially noteworthy in heavy smokers. | Jian-Yong Shao Yun Cao Xiao-Ping Miao Ma-Yan Huang Ling Deng Jian-Jun Hao Xiao-Man Liang Li-Fu Hu Ingemar Ernberg Dong-Xin Lin Yi-Xin Zeng | 2011 | Chinese Journal of Cancer2011，30，9： | 4 |
| 3 | Effect of peripheral NMDA receptor blockade with ketamine on chronic myofascial pain in temporomandibular disorder patients: a randomized, double- blinded, placebo-controlled trial 显示文摘 | Castrillon E E Cairns B E Ernberg M | 2008 | J Orofac Pain2008，22，2： | 1 |
| 4 | Gene expression perturbation in vitro—A growing case for three-dimensional (3D) culture systems显示文摘 | Anna Birgersdotter Rickard Sandberg Ingemar Ernberg | 2005 | Seminars in Cancer Biology2005，，5： | 1 |
| 5 | Radiographic evaluation of the acromioclavicular and sternoclavicular joint显示文摘 | Ernberg LA Potter HG | 2003 | Clin Sports Med2003，22，2： | 1 |
| 6 | Expression of Epstein-Barr virus-encoded membrane proteins in nasopharyngeal carcinoma显示文摘 | Fahraeus R Hu LF Ernberg I | 1988 | Int J Cancer1988，42，： | 1 |
| 7 | Expression of Epstein-Barr virus-encoded membrane proteins in nasopharyngeal carcinoma显示文摘 | Fahraeus R Hu LF Ernberg I | 1988 | Int J Cancer1988，42，3： | 1 |
| 8 | Radiographic evaluation of the acromiocla- vieular and stemoclavieular joints 显示文摘 | Ernberg LA Potter HG | 2003 | Clin Sports Med2003，22，： | 1 |
| 9 | Presence of orofacial pain and tempormandibular disorder in fibromyalgia a study by questionnaire 显示文摘 | Hedenberg MB Ernberg M Kopp S | 1999 | Swed Dent J1999，23，5： | 1 |
| 10 | Epstein-Barr virus: adaptation to a life within the immune system显示文摘 | MASUCCI M G ERNBERG 1 | 1994 | Trends Microbio!''1994，2，4： | 1 |
| 11 | Gene expression perturbation in vitro-a growing case for three-dimensional (3D) culture systems显示文摘 | Birgersdotter A Sandberg R Ernberg I | | 0，，05： | 1 |
| 12 | N-terminal pro- brain natriuretic peptide in relation to inflammation,myo- cardial necrosis, and the effect of an invasive strategy in unstable coronary artery disease显示文摘 | J ernberg T Lindahl B Siegbahn A | 2003 | J Am Coll Cardiol2003，42，11： | 1 |
| 13 | Presence of orofacial pain and temporomandibular disorder in fibromyalgia a study by questionnaire显示文摘 | Hedenberg MB Ernberg M Kopp S | 1999 | Swed Dent J1999，23，5： | 1 |
| 14 | A statistical-based sequential method for fast online detection of fault-induced voltage dips显示文摘 | GU I Y H ERNBERG N STYVAKTAKIS E | 2004 | IEEE Trans Power Delivery2004，19，2： | 1 |
| 15 | Raji revisited : cytogenetics of the original Burkitt's lymphoma cell line显示文摘 | KARPOVA M B SCHOUMANS J ERNBERG I | 2005 | Leukemia2005，19，1： | 1 |
| 16 | A biomechanical evaluation of the long stem intermedullery hip screw显示文摘 | Lyden JP Ernberg JJ | 1995 | J Orthop Trauma1995，9，： | 1 |
| 17 | Epstein-Barr virus:adaptation to a life within the immune system显示文摘 | MASUCCI M G ERNBERG I | 1994 | Trends Microbiol1994，2，4： | 1 |
| 18 | Cancellous bone screw thead design and holding power显示文摘 | Asnis SE Ernberg JJ Bostro= MP | 1996 | J Orthop Trauma1996，10，： | 1 |
| 19 | Epstein - Barr virus LMP1 status in relation to apoptosis, p53 expression and leucocyte infiltration in nasopharyngeal carcinoma显示文摘 | Shao J Y Ernberg I Biberfeld P | 2004 | Anticancer Res2004，24，4： | 1 |
| 20 | Presence of orofacial pain and tempormandibular disorder in fibromyalgia A study by questionnaire显示文摘 | Hedenberg M B Ernberg M Kopp S | 1999 | Swed D J1999，23，5： | 1 |
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