|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog显示文摘Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 10 |
| 2 | Mesenchymal stromal cells' role in tumor microenvironment:involvement of signaling pathways显示文摘Mesenchymal stromal cells(MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like 'wounds that do not heal.' In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 4 |
| 3 | The Lebesgue integral as a Riemann integral显示文摘 | Gonzale-Velasco Erique A | 1987 | 1987，，40： | 1 |
| 4 | Up-regulated expression of ADAM17 in human colon carcinoma:co-expression with EGFR in neoplastic and endothelial cells显示文摘 | Fr'ed'erique Blanchot-Jossic Anne Jarry Damien Masson | 2005 | J Pathol2005，207，： | 1 |
| 5 | Voriconazole, Combined with Amphotericin B, in the Treatment for Pulmonary Cryptococcosis Caused by C. neoformans (Serotype A) in Mice with Severe Combined Immunodeficiency (SCID)显示文摘 | Eriques Silva Claudete Paula Francisco Assis Baroni Walderez Gambale | 2012 | Mycopathologia2012，，5： | 1 |
| 6 | May-Thurner syndrome : di- agnosis and management显示文摘 | Nicholas F Harlan B Erique G | 2013 | Vasa2013，42，2： | 1 |
| 7 | Archaeological Evidence for the Emergence of Language,Symbolism,and Music-An Alternative Multidisciplinary Perspective显示文摘 | Francesco d'Errico Christopher Henshilwood Graeme Lawson Marian Vanhaeren Anne-Marie Tillier Marie Soressi Fred erique Bresson Bruno Maureille April Nowell Joseba Lakarra Lucinda Backwell Michele Julien | 2003 | Journal of World Prehistory2003，，17： | 1 |
| 8 | New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers显示文摘Breast cancer is the most frequent female malignancy worldwide. Current strategies in breast cancer therapy,including classical chemotherapy, hormone therapy, and targeted therapies, are usually associated with chemoresistance and serious adverse effects. Advances in our understanding of changes affecting the interactome in advanced and chemoresistant breast tumors have provided novel therapeutic targets, including, cyclin dependent kinases, mammalian target of rapamycin,Notch, Wnt and Shh. Inhibitors of these molecules recently entered clinical trials in mono- and combination therapy in metastatic and chemo-resistant breast cancers. Anticancer epigenetic drugs, mainly histone deacetylase inhibitors and DNA methyltransferase inhibitors, also entered clinical trials. Because of the complexity and heterogeneity of breast cancer, the future in therapy lies in the application of individualized tailored regimens. Emerging therapeutic targets and the implications for personalized-based therapy development in breast cancer are herein discussed. | Armel Hervé Nwabo Kamdje Paul Faustin Seke Etet Lorella Vecchio Richard Simo Tagne Jeremie Mbo Amvene Jean-Marc Muller Mauro Krampera Kiven Erique Lukong | 2014 | World Journal of Clinical Cases2014，2，12： | 1 |
| 9 | Intrasellar Chondroid Chordoma: A Case Report显示文摘 | Renata M. Hirosawa Antonio B. A. Santos Mariana M. Fran?a Viciany Erique Fabris Ana Valéria B. Castro Marco A. Zanini Vania S. Nunes A. De Bellis J. A. Rillema O. Serri | 2011 | ISRN Endocrinology2011，，： | 1 |
| 10 | Emerging data supporting stromal cell therapeutic potential in cancer:reprogramming stromal cells of the tumor microenvironment for anti-cancer effects显示文摘After more than a decade of controversy on the role of stromal cells in the tumor microenvironment,the emerging data shed light on pro-tumorigenic and potential anti-cancer factors,as well as on the roots of the discrepancies.We discuss the pro-tumorigenic effects of stromal cells,considering the effects of tumor drivers like hypoxia and tumor stiffness on these cells,as well as stromal cell-mediated adiposity and immunosuppression in the tumor microenvironment,and cancer initiating cells'cellular senescence and adaptive metabolism.We summarize the emerging data supporting stromal cell therapeutic potential in cancer,discuss the possibility to reprogram stromal cells of the tumor microenvironment for anti-cancer effects,and explore some causes of discrepancies on the roles of stromal cells in cancer in the available literature. | Armel H.Nwabo Kamdje Paul F.Seke Etet Richard Tagne Simo Lorella Vecchio Kiven Erique Lukong Mauro Krampera | 2020 | Cancer Biology & Medicine2020，17，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员