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| 1 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 2 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 3 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 4 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 2 |
| 5 | Exploratory bioavailability and pharmacokinetic studies of sulphadime-thoxine and ormetoprim in the penaeid shrimp, Penaeus vannamei 显示文摘 | Eric D P Donald V L Nicholas M | 1995 | Aquaculture1995，130，： | 1 |
| 6 | A content analy- sis of the comprehensive income exposure draft comment letters 显示文摘 | Yen A C Eric Hirst D Hopkins P E | 2007 | Research in Accounting Regulation2007，19，： | 1 |
| 7 | Regulation of freezing tolerance, flowering in temperate cereals: the VRN-1 connection显示文摘 | Taniya D Stephen P P Eric J S | 2010 | Plant Physiology2010，153，4： | 1 |
| 8 | Genetic diversity among witchhazel cultivars based on Randomly Amplified Polymorphic DNA markers显示文摘 | Robert D Marquard Eric P Davis Emily L Stowe | 1997 | J Amer Soc Hort Sci1997，122，4： | 1 |
| 9 | Azide and Cyanide Displacements via Hypervalent Silicate Intermediates 显示文摘 | ERIC D S AMY S M MICHAEL C P | 1999 | J Org Chem1999，64，： | 1 |
| 10 | Fluorinated Copolymer-oxide Hybrids 显示文摘 | Eric P B Atif N John D M | 2004 | J Sol-Gel Sci Technol2004，32，13： | 1 |
| 11 | Long- range oxidation of guanine by Ru (111) in duplex DNA 显示文摘 | Michelle R A Eric D A S Sabine C P | 1997 | Chem Biol1997，4，： | 1 |
| 12 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 1 |
| 13 | Low diagnostic yield of elective coronary angiography显示文摘 | Manesh P Eric DP David D | 2010 | N Engl J Med2010，362，10： | 1 |
| 14 | Thermal Analysis of Automotive Lamps Using the ADINA-F Coupled Specular Radiation and Natural Convection Model显示文摘 | William I M Eric S D Christopher R P | 1999 | Computers & Structures1999，72，1： | 1 |
| 15 | Determination of dissolved organic nitrogen in natural waters using high-temperature catalytic oxidation显示文摘 | E1-Sayed A B Eric P A Alan D T | 2003 | Trends in analytical chemistry2003，22，11： | 1 |
| 16 | Nickel and cobalt sorption on anaerobic granular sludges:kinetic and equilibrium studies显示文摘 | Hullebusch Eric D V Zandvoort M H Lens P N L | 2004 | Journal of Chemical Technology and Biotechnology2004，79，： | 1 |
| 17 | Development and evaluation of autotuning and adaptive PID controller显示文摘 | Andre D | 1996 | Automatica1996，32，1： | 1 |
| 18 | GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap显示文摘 | ERIC G ISABELLE D MICHAEL P | 2002 | European Journal of Neuroscience2002，15，4： | 1 |
| 19 | Caspases and programmed cell death in the hypersensitive response of plants to pathogens显示文摘 | OLGA D P ERIC L | 1998 | Current Biology1998，8，： | 1 |
| 20 | Explorato- ry bioavailability and pharmacokinetie studies of sulph- adimethoxine and ormetoprim in the penaeid shrimp, Penaens vannamei 显示文摘 | Eric D P Donald V L Nicholas M | 1995 | Aquaculture1995，130，2： | 1 |
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