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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 3 | Spatial differences in rock uplift rates inferred from channel steepness indices along the northern flank of the Qilian Mountain,northeast Tibetan Plateau显示文摘The rate and distribution of deformation along the Qilian Mountain,on the northeastern Tibetan Plateau,is needed to understand the evolution of high topography associated with the plateau.Recently,a number of empirical studies have provided support for the contention,common to most models of fluvial incision,that rock uplift rate exerts a first-order control on the gradient of longitudinal river profiles.Along the northern Qilian Mountain,this method is used to extract information about the spatial patterns of differential rock uplift.Analysis of the longitudinal profiles of bedrock channels reveals systematic differences in the channel steepness index along the trend of the frontal ranges.Local comparisons of channel steepness reveal that lithology and precipitation have limited influence on channel steepness.Similarly,there is little evidence suggesting that channel steepness is influenced by differences in the sediment loads.We argue that the distribution of channel steepness in the Qilian Mountain is mostly the result of differential rates of rock uplift.Thus,channel steepness indices reveal a lower rock uplift rate in the eastern portion of the Qilian Mountain and a higher rate in the middle and west.The highest rates appear to occur in the middle-west portions of the range,just to the west of the Yumu Shan. | HU XlaoFei PAN BaoTian KIRBY Eric LI QingYang GENG HaoPeng CHEN JiFeng | 2010 | Chinese Science Bulletin2010，55，27： | 35 |
| 4 | Amyloid beta: structure, biology and structure-based therapeutic development显示文摘淀粉的贝它肽(A) 通过 transmembrane 蛋白质的解朊的处理被生产,淀粉的先锋蛋白质(应用软件) ,由 - 并且 -secretases。在大脑的累积被建议是在 Alzheimers 疾病的致病的一个早有毒的事件,它是在大脑与匾和混乱联系的痴呆的最普通的形式。当前, A 的生理、病理学的形式是什么,是不清楚的并且由由什么机制, A 引起痴呆。而且,没有有效的药停止或逆行 Alzheimers 的前进疾病。在这份报纸,我们考察 A 的结构,生物功能,和 neurotoxicity 角色。我们也讨论与 A 交往并且调停的潜在的受体吸入,清理,和新陈代谢。另外,我们为治疗 Alzheimers 疾病总结治疗学的开发和不同策略的最近的进展。最后,我们将在象为 Alzheimers 疾病的治疗答应策略选择一样寻找新奇、潜在地有效的代理人在进步上报导。这些前景包括对 A,它的受体和字形物蛋白质起作用的代理人,例如对 A 的小分子,疫苗和抗体;禁止者或调节的人 - 并且 -secretase;降级 A 的朊酶;字形物蛋白质禁止者和疫苗;淀粉的染料和 microRNAs。 | Guo-fang CHEN Ting-hai XU Yan YAN Yu-ren ZHOU Yi JIANG Karsten MELCHER H Eric XU | 2017 | Acta Pharmacologica Sinica2017，38，9： | 39 |
| 5 | Laparoscopic liver resection under hemihepatic vascular inflow occlusion using the lowering of hilar plate approach显示文摘BACKGROUND: With advances in technology, laparoscopic liver resection is widely accepted. Laparoscopic liver resection under hemihepatic vascular inflow occlusion has advantages over the conventional total hepatic inflow occlusion using the Pringle's maneuver, especially in patients with cirrhosis.METHOD: From November 2011 to August 2012, eight consecutive patients underwent laparoscopic liver resection under hemihepatic vascular inflow occlusion using the lowering of hilar plate approach with biliary bougie assistance.RESULTS: The types of liver resection included right hepatectomy(n1), right posterior sectionectomy(n1), left hepatectomy and common bile duct exploration(n1), segment 4b resection(n1), left lateral sectionectomy(n2), and wedge resection(n2). Four patients underwent right and 4 left hemihepatic vascular inflow occlusion. Four patients had cirrhosis. The mean operation time was 176.3 minutes. The mean time taken to achieve hemihepatic vascular inflow occlusion was 24.3minutes. The mean duration of vascular inflow occlusion was54.5 minutes. The mean intraoperative blood loss was 361 mL.No patient required blood transfusion. Postoperatively, one patient developed bile leak which healed with conservative treatment. No postoperative liver failure and mortality occurred. The mean hospital stay of the patients was 7 days.CONCLUSION: Our technique of hemihepatic vascular inflow vascular occlusion using the lowering of hilar plate approachwas safe, and it improved laparoscopic liver resection by minimizing blood loss during liver parenchymal transection. | Ying-Jun Chen Zuo-Jun Zhen Huan-Wei Chen Eric CH Lai Fei-Wen Deng Qing-Han Li Wan Yee Lau | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，5： | 23 |
| 6 | Wheat, maize and sunflower cropping systems selectively influence bacteria community structure and diversity in their and succeeding crop's rhizosphere显示文摘Wheat and maize are increasingly used as alternative crops to sunflower monocultures that dominate the Hetao Irrigation District in China.Shifts from sunflower monocultures to alternate cropping systems may have significant effects on belowground microbial communities which control nutrient cycling and influence plant productivity.In this research,rhizosphere bacterial communities were compared among sunflower,wheat and maize cropping systems by 454 pyrosequencing.These cropping systems included 2 years wheat(cultivar Yongliang 4) and maize(cultivar Sidan 19) monoculture,more than 20 years sunflower(cultivar 5009) monoculture,and wheat-sunflower and maize-sunflower rotation.In addition,we investigated rhizosphere bacterial communities of healthy and diseased plants at maturity to determine the relationship between plant health and rotation effect.The results revealed taxonomic information about the overall bacterial community.And significant differences in bacterial community structure were detected among these cropping systems.Eight of the most abundant groups including Proteobacteria,Bacteroidetes,Acidobacteria,Gemmatimonadetes,Chloroflexi,Actinobacteria,Planctomycetes and Firmicutes accounted for more than 85%of the sequences in each treatment.The wheat-wheat rhizosphere had the highest proportion of Acidobacteria,Bacteroidetes and the lowest proportion of unclassified bacteria.Wheat-sunflower cropping system showed more abundant Acidobacteria than maize-sunflower and sunflower monoculture,exhibiting some influences of wheat on the succeeding crop.Maize-maize rhizosphere had the highest proportion of γ-Proteobacteria,Pseudomonadales and the lowest proportion of Acidobacteria.Sunflower rotation with wheat and maize could increase the relative abundance of the Acidobacteria while decrease the relative abundance of the unclassified phyla,as was similar with the health plants.This suggests some positive impacts of rotation with wheat and maize on the bacterial communities within a single field.These results demonstrate that different crop rotation systems can have significant effects on rhizosphere microbiomes that potentially alter plant productivities in agricultural systems. | WEN Xin-ya Eric Dubinsky WU Yao YU Rong CHEN Fu | 2016 | Journal of Integrative Agriculture2016，15，8： | 18 |
| 7 | Site effects on earthquake ground motion based on microtremor measurements for metropolitan Beijing显示文摘A campaign of microtremor measurements was conducted in summer 2007 for assessing local site effects of seismic strong ground motion in metropolitan Beijing. Using the measurements from over 600 sites with approximately 1―2 km spacing covering the entire area inside Beijing’s 5th Beltway, we present the analysis results in the form of contours of the predominant resonant frequency, the thick- ness of the uppermost soft sediments, and the ground motion amplification factor. The microtremor- derived soft sediment thickness is generally in agreement with previous results based on much sparser borehole data, with the revealing of more short-wavelength undulations, which coincide with major geomorphological and neotectonic expressions in metropolitan Beijing. This study provides additional valuable information to the earthquake-resistant design of civil infrastructures and seismic hazard response in metropolitan Beijing. It also provides a feasible geophysical approaching to explore the 3-D structure beneath metropolitan cities. | CHEN QiFu LIU LanBo WANG WeiJun ROHRBACH Eric | 2009 | Chinese Science Bulletin2009，54，2： | 15 |
| 8 | The endless tale of non-homologous end-joining显示文摘脱氧核糖核酸双海滨裂缝(DSB ) 被离子辐射和反应的氧种类在房间介绍。另外,他们通常在 V (D) J 再结合期间被产生,发展中的免疫系统的一个必要方面。有效地修理这些 DSB 的失败能在更高的脊椎动物的免疫系统导致染色体破裂,房间死亡,癌症的发作,和缺点。幸好,所有哺乳动物的房间拥有调停的二条酶的小径 DSB 的修理:相应再结合并且非相应加入结束(NHEJ ) 。NHEJ 过程利用捕获破脱氧核糖核酸分子的两结束,在 synaptic DNA 蛋白质建筑群一起带他们,并且最后修理脱氧核糖核酸裂缝的酶。在这评论,在 NHEJ 过程起一个作用的所有已知的酶被讨论,为这些酶的合作的一个工作模型在 DSB 修理期间被介绍。 | Eric Weterings David J Chen | 2008 | Cell Research2008，18，1： | 13 |
| 9 | Influence of Garlic Intercropping or Active Emitted Volatiles in Releasers on Aphid and Related Beneficial in Wheat Fields in China显示文摘In order to develop biological control of aphids by a 'push-pull'approach, intercropping using repellent emitting plants was developed in different crop and associated plant models. Garlic is one of the potential plant that could be inserted in crops to decrease the pest occurrence in neighboring crop plots. In this study, field works were conducted in wheat fields in Langfang Experimental Station, Hebei Province in China from October 2009 to July 2010 during wheat developmental season. The effect of wheat intercropping with garlic but also the volatiles emission on the incidence of the English grain aphid, Sitobion avenae Fabricius (Homoptera: Aphididae) was assessed. Natural beneficial occurrence and global yields in two winter wheat varieties that were susceptible or resistant to cereal aphid were also determined comparing to control plots without the use of garlic plant intercrop nor semiochemical releaser in the fields. S. avenae was found to be lower in garlic oil blend treatment (GOB), diallyl disulfide treatment (DD) and wheat-garlic intercropping treatment (WGI) when compared to the control plots for both two varieties (P<0.01). Both intercropping and application of volatile chemicals emitted by garlic could improve the population densities of natural enemies of cereal aphid, including ladybeetles and mummified aphids. Ladybeetle population density in WGI, GOB and mummified aphids densities in WGI, DD were significantly higher than those in control fields for both two varieties (P<0.05). There were significant interactions between cultivars and treatments to the population densities of S. avenae. The 1 000-grain weight and yield of wheat were also increased compared to the control. Due to their potential alternatives as a biological control agent against cereal aphid, garlic intercropping and related emitted volatiles are expected to contribute to the further improvement of integrated pest management systems and to potentially reduce the amount of traditional synthetic pesticides applied in wheat fields. | ZHOU Hai-bo CHEN Ju-lian LIU Yong Frédéric Francis Eric Haubruge Claude Bragard SUN Jing-rui CHENG Deng-fa | 2013 | Journal of Integrative Agriculture2013，12，3： | 12 |
| 10 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 11 | Stem Cell Regulation by Arabidopsis WOX Genes显示文摘功能的多样化跟随的基因扩大是在进化的主要力量。这的一个典型例子在 WUSCHEL 相关的 HOMEOBOX (WOX ) 基因家庭被看见,依照 Arabidopsis 干细胞管理者 WUSCHEL 命名。这里,我们在 WOX 基因家庭分析功能的分叉。除了形成层干细胞管理者 WOX4, WUS clade 的成员能在射击和花的干细胞维护代替 WUS 功能到不同的度。WUS 的干细胞功能要求正规 WUS 盒子,为和 TPL/TPR 合作抑压者的相互作用必要,而压抑的耳朵领域是非必需的,酸的领域仅仅似乎为女富饶被要求。与 WUS clade 相对照,古老的 WOX13 和 WOX9 clades 的成员不能支持干细胞维护。尽管 homeodomains 在 WUS 和 WOX9 clade 成员之间是可互换的,和正规 WUS 盒子的 WUS 兼容的 homeodomain 不为干细胞维护是足够的。我们的结果建议在射击和 Arabidopsis 的花的分裂组织的那个 WOX 函数被限制为现代 WUS clade,建议干细胞控制是一个导出的函数。除了 homeodomain 和 WUS 盒子的然而未被发现的功能的领域为这功能是必要的。 | Alicja Dolzblasz Judith Nardmann Elena Clerici Barry Causier Eric van der Graaff Jinhui Chen Brendan Davies Wolfgang Werr Thomas Laux | 2016 | Molecular Plant2016，9，7： | 11 |
| 12 | Recently duplicated sesterterpene(C25) gene clusters in Arabidopsis thaliana modulate root microbiota显示文摘Land plants co-speciate with a diversity of continually expanding plant specialized metabolites(PSMs) and root microbial communities(microbiota).Homeostatic interactions between plants and root microbiota are essential for plant survival in natural environments.A growing appreciation of microbiota for plant health is fuelling rapid advances in genetic mechanisms of controlling microbiota by host plants.PSMs have long been proposed to mediate plant and single microbe interactions.However,the effects of PSMs,especially those evolutionarily new PSMs,on root microbiota at community level remain to be elucidated.Here,we discovered sesterterpenes in Arabidopsis thaliana,produced by recently duplicated prenyltransferase-terpene synthase(PT-TPS) gene clusters,with neo-functionalization.A single-residue substitution played a critical role in the acquisition of sesterterpene synthase(sesterTPS) activity in Brassicaceae plants.Moreover,we found that the absence of two root-specific sesterterpenoids,with similar chemical structure,significantly affected root microbiota assembly in similar patterns.Our results not only demonstrate the sensitivity of plant microbiota to PSMs but also establish a complete framework of host plants to control root microbiota composition through evolutionarily dynamic PSMs. | Qingwen Chen Ting Jiang Yong-Xin Liu Haili Liu Tao Zhao Zhixi Liu Xiangchao Gan Asis Hallab Xuemei Wang Juan He Yihua Ma Fengxia Zhang Tao Jin M. Eric Schranz Yong Wang Yang Bai Guodong Wang | 2019 | Science China(Life Sciences)2019，62，7： | 11 |
| 13 | The mucosal immune system in the oral cavity——an orchestra of T cell diversity显示文摘The mucosal immune system defends against a vast array of pathogens, yet it exhibits limited responses to commensal microorganisms under healthy conditions. The oral-pharyngeal cavity, the gateway for both the gastrointestinal and respiratory tracts, is composed of complex anatomical structures and is constantly challenged by antigens from air and food. The mucosal immune system of the oral-pharyngeal cavity must prevent pathogen entry while maintaining immune homeostasis, which is achieved via a range of mechanisms that are similar or different to those utilized by the gastrointestinal immune system. In this review, we summarize the features of the mucosal immune system,focusing on T cell subsets and their functions. We also discuss our current understanding of the oral-pharyngeal mucosal immune system. | Rui-Qing Wu Dun-Fang Zhang Eric Tu Qian-Ming Chen WanJun Chen | 2014 | International Journal of Oral Science2014，6，3： | 10 |
| 14 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 15 | Genomic Analyses Yield Markers for Identifying Agronomically Important Genes in Potato显示文摘野土豆种类有实质的 phenotypic 和生理的差异。这里,我们基于茄属节 Petota 的 201 就职的 genomic 分析报导对野、栽培的土豆种类的一个全面评价。我们定序这 201 就职的染色体并且识别了 6 ? 487 ? 从在 clade 的 167 就职的 006 高质量的单个核苷酸多型性(SNP ) 4 茄属节 Petota,包括 146 野并且有宽广地理分布的 21 栽培双土豆就职。染色体宽的基因变化分析比栽培土豆,和在农学地重要的疾病抵抗的高得多的基因差异,基因在野土豆被观察的证明野土豆的差异高。由关于已知的量的特点 loci (QTL ) 利用信息,而且,我们在选择下面识别了 609 基因,包括那些在 tubers 与痛苦的损失相关,那些在 tuberization 包含了,土豆的二个主要驯养的特点。种系发生的分析在 clade 揭示了所有种类的一个纵贯的部门 4,不是就那些在 S.? brevicaule 建筑群,和进一步支持的 S。是的 candolleanum 栽培土豆和在南部的秘鲁的栽培土豆的 monophyletic 起源的祖先。另外,我们分析了 S. 的染色体 ? candolleanum 并且鉴别 529 基因在栽培土豆输了。一起,在这研究产生的分子的标记为为土豆繁殖有用的农学地重要的基因的鉴定提供一个珍贵资源。 | Yangping Li Christophe Colleoni Junjie Zhang Qiqi Liang Yufeng Hu Holly Ruess Reinhard Simon Yinghong Liu Hanmei Liu Guowu Yu Eric Schmitt Ghloe Ponitzki Guangjian Liu Huanhuan Huang Feilong Zhan Lin Chen Yubi Huang David Spooner Binquan Huang | 2018 | Molecular Plant2018，11，3： | 8 |
| 16 | New frontiers for the materials genome initiative显示文摘The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and experiment.Along with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the MGI.In May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and theory.This article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts. | Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao | 2019 | npj Computational Materials2019，，1： | 7 |
| 17 | Ambient noise as the new source for urban engineering seismology and earthquake engineering: a case study from Beijing metropolitan area显示文摘In highly populated urban centers, traditional seismic survey sources can no longer be properly applied due to restrictions in modern civilian life styles. The ambient vibration noise, including both microseisms and microtremor, though are generally weak but available anywhere and anytime, can be an ideal supplementary source for conducting seismic surveys for engineering seismology and earthquake engineering. This is fundamentally supported by advanced digital signal processing techniques for effectively extracting the useful information out from the noise. Thus, it can be essentially regarded as a passive seismic method. In this paper we first make a brief survey of the ambient vibration noise, followed by a quick summary of digital signal processing for passive seismic surveys. Then the applications of ambient noise in engineering seismology and earthquake engineering for urban settings are illustrated with examples from Beijing metropolitan area. For engineering seismology the example is the assessment of site effect in a large area via microtremor observations. For earthquake engineering the example is for structural characterization of a typical reinforced concrete high-rise building using background vibration noise.By showing these examples we argue that the ambient noise can be treated as a new source that is economical, practical, and particularly valuable to engineering seismology and earthquake engineering projects for seismic hazard mitigation in urban areas. | Lanbo Liu Qi-fu Chen Weijun Wang Eric Rohrbach | 2014 | Earthquake Science2014，27，1： | 7 |
| 18 | Hepatoid adenocarcinoma of the colon in a patient with inflammatory bowel disease显示文摘A case is presented of a 36-year-old male with primary sclerosing cholangitis-associated inflammatory bowel disease(PSC-IBD) and two synchronous stage 1 adenocarcinomata of the colon,who was initially treated with a subtotal colectomy with ileostomy.One year later,the patient presented with extensive intra-abdominal lymphadenopathy and peritoneal carcinomatosis,as well as a markedly elevated serum level of alpha-fetoprotein(AFP).Fine needle aspiration biopsy of a porta hepatis lymph node revealed a metastatic hepatoid adenocarcinoma.Subsequent review of the previous colectomy specimen showed that one of the previously identified adenocarcinomata had features suggestive of a hepatoid colonic adenocarcinoma.The patient was subsequently treated with a cytotoxic regimen of FOLFOX(oxaliplatin,leucovorin,5-fluorouracil) and bevacizumab,with stable results being achieved after six months.This case presents the first known report of PSC-IBD associated with synchronous typical and hepatoid adenocarcinomata of the colon and highlights the importance of considering hepatoid adenocarcinoma as a differential diagnosis in patients with an increasing serum AFP level. | Yuanyuan Chen David F Schaeffer Eric M Yoshida | 2014 | World Journal of Gastroenterology2014，20，35： | 6 |
| 19 | Coupled alkali feldspar dissolution and secondary mineral precipitation in batch systems: 5. Results of K-feldspar hydrolysis experiments显示文摘This paper explores how dissolution and precipitation reactions are coupled in batch reactor experimental systems at elevated temperatures. This is the fifth paper in our series of ‘‘Coupled Alkali Feldspar Dissolution and Secondary Mineral Precipitation in Batch Systems.'' In the previous four papers we presented batch experiments of alkali-feldspar hydrolysis and explored the coupling of dissolution and precipitation reactions(Fu et al. in Chem Geol91:955–964, 2009; Zhu and Lu in Geochim Cosmochim Acta 73:3171–3200, 2009; Zhu et al.in Geochim Cosmochim Acta 74:3963–3983, 2010; Lu et al. in Appl Geochem30:75–90, 2013). Here, we present the results of additionalK-rich feldspar hydrolysis experiments at 150 °C. Our solution chemistry measurements have constrained feldspar dissolution rates, and our high resolution transmission electron microscopy work has identified boehmite precipitation. Reaction path modeling of K-feldspar dissolution and boehmite precipitation simulated the coupled reactions, but only with forced changes of boehmite rate law in the middle of experimental duration. The results which are reported in this article lend further support to our hypothesis that slow secondary mineral precipitation explains part of the wellknown apparent discrepancy between lab measured and field estimated feldspar dissolution rates(Zhu et al. in Water–rock interaction, 2004). | Peng Lu Hiromi Konishi Eric Oelkers Chen Zhu | 2015 | Chinese Journal Of Geochemistry2015，34，1： | 5 |
| 20 | High Potential Columnar Nanocrystalline AlN Films Deposited by RF Reactive Magnetron Sputtering显示文摘Columnar nanocrystalline aluminum nitride(cnc-AlN) thin films with(002) orientation and uniform texture have been deposited successfully on large silicon wafers by RF reactive magnetron sputtering.At the optimum sputtering parameters, the deposited cnc-AlN thin films show a c-axis preferred orientation with a crystallite size of about 28 nm and surface roughness(RMS) of about 1.29 nm. The cnc-AlN thin films were well transparent with an optical band gap about 4.8 e V, and the residual compressive stress and the defect density in the film have been revealed by Ramon spectroscopy. Moreover, piezoelectric performances of the cnc-AlN thin films executed effectively in a film bulk acoustic resonator structure. | Chengzhang Han Da Chen Yaozhong Zhang Dong Xu Yijian Liu Eric Siu-Wai Kong Yafei Zhang | 2012 | Nano-Micro Letters2012，4，1： | 4 |
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