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	题名	作者	年代	出处	被引量
1	Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.	Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong	2017	World Journal of Gastroenterology2017，23，6：	2
2	Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis 显示文摘	Ercan B Ayaz L Cicek D	2008	CellBioehemFunct2008，26，30：	1
3	Novel mutant-selective EGFR kinase inhibitors against EGFR T790M显示文摘	Zhou W Ercan D Chen L	2009	Nature2009，462，7276：	1
4	Novel mutant-selective EGFR kinase inhibitors against EGFR T790M显示文摘	Zhou W Ercan D Chen L		0，，：	1
5	Novel mutant-selective EGFR kinase inhibitors against EGFR T790M 显示文摘	Zhou W Ercan D Chert L	2009	Nature2009，462，7276：	1
6	Amplification of EGFR T790M causes resistance to an erreversible EGFR inhibitor显示文摘	Ercan D Zejnullahu K Yonesaka K	2010	Oncogene2010，29，：	1
7	Association of plasma viscosity with cardiovascular risk factors in obesity: an old marker, a new insight显示文摘	Ercan M Konukoglu D Erdem Yeim T	2006	Clin Hemorheol Microcirc2006，35，4：	1
8	The relationship between plasma viscostity and cholesterol in postmenopausal women on hornone replacement therapy显示文摘	Konukoglu D Serin O Ercan M	2000	Clin Hemorheol Microcirc2000，22，3：	1
9	The relationship between plasma viscosity and cholesterol in postmenopausal women on hormone replacement therapy显示文摘	Konukoglu D Sserin O Ercan M et a1	2000	Clin Hemorheol Microcirc2000，22，：	1
10	Weight gain associated with valproate in children显示文摘	Sabiha A	2000	Pediatric neurologe2000，22，：	1
11	The relationship between plasma viscostity and cholesterol in postmenopausal women on hormone replacement therapy显示文摘	Konukoglu D Serin O Ercan M	2000	Clin Hemorheol Microcirc2000，22，3：	1
12	Novel mutant-selec-tive EGFR kinase inhibitors against EGFR T790M显示文摘	Zhou W Ercan D Chen L	2009	Nature2009，462，：	1
13	Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors 显示文摘	Ercan D Xu C Yanagita M	2012	Cancer Discov2012，2，10：	1
14	Relationship between plasma leptin and zinc levels and the effect of insuline and oxidative stress on leptin levels in obese diabetic patients 显示文摘	Konukoglu D Turban MS Ercan M	2004	J Nutr Biochem2004，15，12：	1
15	Prognostic significance of lymph node metastasis found during pulmonary metastasectomy for extrapulmonary carcinoma显示文摘	Sina Ercan Francis C Nichols Victor F Trastek Claude Deschamps Mark S Allen Daniel L Miller Cathy D Schleck Peter C Pairolero	2004	The Annals of Thoracic Surgery2004，，5：	1
16	Novel mutant-selective EGFR ki- nase inhibitors against EGFR T790M 显示文摘	Zhou W Ercan D Chen L	2009	Nature2009，462，7276：	1
17	The relationship between plasma viscostity and cholesterol in postmenopausal women on hornone replacement therapy显示文摘	Konukoglu D Serin O Ercan M	2000	Clin Hemorheol Microcirc2000，22，3：	1
18	Production of human lysozyme in biofilm reactor and optimization of growth parameters of Kluyveromyces lactis K7 显示文摘	Ercan D Demirei A	2013	Appl Microbiol Biotechnol2013，97，14：	1
19	Growth performance of juvenile Russian sturgeon(Acipenser gueldenstaedtii Brandt & Ratzen- burg, 1833) at two stocking densities in net cages显示文摘	Celikkale M S Memis D Ercan E	2005	J Appl Ich- thyol2005，21，：	1
20	EGFR Mutations and resistance to irreversible pyrimidine-based EGFR inhibitors显示文摘	Ercan D Choi H G Yun C H	2015	Clinical Cancer Research2015，21，17：	1

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