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| 1 | Clustering Seismic Activities Using Linear and Nonlinear Discriminant Analysis显示文摘Identification and classification of different seismo-tectonic events with similar characteristics in a region of interest is one of the most important subjects in seismic hazard studies.In this study,linear and nonlinear discriminant analyses have been applied to classify seismic events in the vicinity of Istanbul.The vertical components of the digital velocity seismograms are used for seismic events with magnitude(Md)between 1.8 and 3.0 that occurred between 2001 and 2004.Two,time dependent parameters,complexity and S/P peak amplitude ratio are selected as predictands.Linear,quadratic,diaglinear and diagquadratic discriminant functions are investigated.Accuracy of methods with an additional adjusted quadratic models are 96.6%,96.6%,95.5%,96.6%,and 97.6%,respectively with a various misclassified rate for each class.The performances of models are justified with cross validation and resubstitution error.Although all models remarkably well performed,adjusted quadratic function achieved the best success rate with just 4 misclassified events out of 179,even better compared to complex methods such as,self organizing method,k-means,Gaussion mixture models that applied to same dataset in literature. | H Serdar Kuyuk Eray Yildirim Emrah Dogan Gunduz Horasan | 2014 | Journal of Earth Science2014，25，1： | 4 |
| 2 | Cytoprotective effects of amifostine,ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats显示文摘AIM:To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine(NAC),amifostine(AMF)and ascorbic acid(ASC)in methotrexate(MTX)-induced hepatotoxicity.METHODS:An MTX-induced hepatotoxicity model was established in 44 male Sprague Dawley rats by administration of a single intraperitoneal injection of20 mg/kg MTX.Eleven of the rats were left untreated(Model group;n=11),and the remaining rats were treated with a 7-d course of 50 mg/kg per day NAC (MTX+NAC group;n=11),50 mg/kg per single dose AMF(MTX+AMF group;n=11),or 10 mg/kg per day ASC(MTX+ASC group;n=11).Eleven rats that received no MTX and no treatments served as the negative control group.Structural and functional changes related to MTX-and the various treatments were assessed by histopathological analysis of liver tissues and biochemical assays of malondialdehyde(MDA),superoxide dismutase(SOD),catalase,glutathione(GSH)and xanthine oxidase activities and of serum levels of aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase and total bilirubin.RESULTS:Exposure to MTX caused structural and functional hepatotoxicity,as evidenced by significantly worse histopathological scores[median(range)injury score:control group:1(0-3)vs 7(6-9),P=0.001]and significantly higher MDA activity[409(352-466)nmol/g vs 455.5(419-516)nmol/g,P<0.05].The extent of MTX-induced perturbation of both parameters was reduced by all three cytoprotective agents,but only the reduction in hepatotoxicity scores reached statistical significance[4(3-6)for NAC,4.5(3-5)for AMF and 6(5-6)for ASC;P=0.001,P=0.001 and P<0.005vs model group respectively].Exposure to MTX also caused a significant reduction in the activities of GSH and SOD antioxidants in liver tissues[control group:3.02(2.85-3.43)μmol/g and 71.78(61.88-97.81)U/g vs model group:2.52(2.07-3.34)μmol/g and 61.46(58.27-67.75)U/g,P<0.05];however,only the NAC treatment provided significant increases in these antioxidant enzyme activities[3.22(2.54-3.62)μmol/g and 69.22(61.13-100.88)U/g,P<0.05 and P<0.01vs model group respectively].CONCLUSION:MTX-induced structural and functional damage to hepatic tissues in rats may involve oxidative stress,and cytoprotective agents(NAC>AMF>ASC)may alleviate MTX hepatotoxicity. | Sami Akbulut Hulya Elbe Cengiz Eris Zumrut Dogan Gulten Toprak Emrah Otan Erman Erdemli Yusuf Turkoz | 2014 | World Journal of Gastroenterology2014，20，29： | 3 |
| 3 | Atrial fibrillation may be a hidden factor for the development of cognitive impairment in patients with heart failure显示文摘 | Omer Yiginer Alptug Tokatli Mehmet Dogan Emrah Erdal | 2015 | Journal of Geriatric Cardiology2015，12，5： | 2 |
| 4 | Application of artificial neural networks to estimate wastewater treatment plant inlet biochemical oxygen demand显示文摘 | ATES ASUDE YILMAZ ECECEREN EREN BEYTULLAH | 2008 | Environmental Progress2008，27，4： | 1 |
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