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| 1 | E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome显示文摘瞄准:调查在颜色在转移的进程期间发生在 E-cadherin 表示的变化表面的癌症。方法:E-cadherin 表示被免疫组织化学检测,表示的二个索引是计算的它反映了表示和地点(膜和细胞质) 的水平。Univariate 并且多,变量幸存分析被用来作为两个的预言者估计这二个 E-cadherin 索引的价值没有疾病(DFS ) 并且疾病特定(决策支持系统) 幸存。结果:E-cadherin 膜索引(MI ) ,然而并非细胞质的索引(CI ) ,比他们的转移在原发性瘤是显著地更高的(P = 0.0001 ) 。而且,原发性瘤 MI 和 CI 在开发了随后的转移的病人之中是更高的(P = 0.022 并且 P = 0.007,分别地) 。有趣地,两个索引在与另外的解剖地点相比的肝转移是更高的(MI, P = 0.034 并且 CI, P = 0.022 ) 。原发性瘤的 CI 是 DFS 的一个重要预言者(P = 0.042, univariate 分析) ,与在 CI 和 DFS 之间的强壮的反的关联(P = 0.006,多变量分析) 。最后,原发性瘤的 MI 证明了是决策支持系统的一个重要独立预言者,与与更有利的结果被联系的更高的索引(P = 0.016 ) 。结论:在颜色的 E-cadherin 表示和分发的检查表面的肿瘤能在预言是极其珍贵的疾病复发。E-cadherin 的异常细胞质的表示能预言疾病复发为病人和临床医生显然是很重要的,并且显著地有关病人的治疗和管理影响决定的观察。 | Adam Elzagheid Annika lgars Riyad Bendardaf Hanan Lamlum Raija Ristamaki Yrjo Collan Kari Syrjanen Seppo Pyrhonen | 2006 | World Journal of Gastroenterology2006，12，27： | 17 |
| 2 | Nuclear β-catenin expression as a prognostic factor in advanced colorectal carcinoma显示文摘AIM: To investigate the changing pattern of β-catenin expression and its prognostic value in advanced colorectal cancer (CRC). METHODS: Archival tumor samples were analyzed for β-catenin using immunohistochemistry (IHC) in 95 patients with advanced CRC. RESULTS: Membranous β-catenin expression was found in the normal colorectal epithelium. Almost 100% of CRC cases showed membranous and cytoplasmic expression,and 55 (58%) cases showed nuclear expression. In univariate (Kaplan-Meier) survival analysis,only the nuclear index (NI) was a signifi cant predictor of disease-free survival (DFS) (P = 0.023; n = 35),with a NI above the median associated with longer DFS (34.2 mo) than those with a NI below the median (15.5 mo) (P = 0.045,ANOVA). The other indices were not significant predictors of DFS,and none of the three tested indices (for membranous,cytoplasmic,or nuclear expression) predicted disease-specific survival (DSS). However,when dichotomized as positive or negative nuclear expression,the former was a signifi cant predictor of more favorable DFS (P = 0.041) and DSS (P = 0.046). CONCLUSION: Nuclear β-catenin expression provides additional information in predicting patient outcome in advanced CRC. | Adam Elzagheid Abdelbaset Buhmeida Eija Korkeila Yrj Collan Kari Syrjnen Seppo Pyrhnen | 2008 | World Journal of Gastroenterology2008，14，24： | 13 |
| 3 | Loss of MUC2 expression predicts disease recurrence and poor outcome in colorectal carcinoma显示文摘 | Adam Elzagheid Fatma Emaetig Abdelbaset Buhmeida Matti Laato Omran El-Faitori Kari Syrj?nen Yrj? Collan Seppo Pyrh?nen | 2013 | Tumor Biology2013，，2： | 2 |
| 4 | E - eadherin, CD44s and CD44v6correlate with tumour differentiation in eoloreetal cancer 显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | OncolRep2005，13，5： | 1 |
| 5 | Up-regulation of α-catenin is associated with increased lymph node involvement in colorectal cancer显示文摘AIM: To investigate the changing pattern of α-catenin expression and its relationship to clinical and pathological features of colorectal cancer (CRC) patients. METHODS: Archival tumor samples were analyzed using immunohistochemistry (IHC) for α-catenin in 91 patients with advanced CRC. RESULTS: The values of α-catenin membrane index (MI) and cytoplasmic index (CI) were significantly related to the depth of tumor invasion (P = 0.027, P = 0.020, respectively), high indices being associated with increased depth of the primary tumor invasion (T3 and T4). Similarly, patients with high α-catenin expression had a signifi cantly increased risk of lymph node metastasis (32/39 vs 37/52 for MI and 37/45 vs 32/46 for CI) (P = 0.001, P = 0.0001, respectively, for LNN status). An altered expression (i.e., cytoplasmic pattern) was also related (P = 0.047) to the response to chemotherapy; patients with low CI were more responsive (CR: 7/46) than patients with high CI values (CR: 0/45). There was a marginal effect on survival in patients time with metastases (SWM) (P = 0.087); patients with low CI showing slightly longerSWM, but no such effect on disease free survival (DFS) or disease specifi c survival (DSS). As to co-expression with another member of the adhesion complex (β-catenin), high α-catenin/β-catenin MI index was of marginal signifi cance in predicting longer DSS (P = 0.063, log-rank). CONCLUSION: The results implicate that high α-catenin expression is intimately involved in the key regulatory mechanisms leading to invasive phenotype, lymph node metastases, and progressive disease in CRC. | Adam Elzagheid Abdelbaset Buhmeida Eija Korkeila Yrj Collan Kari Syrjnen Seppo Pyrhnen | 2008 | World Journal of Gastroenterology2008，14，31： | 1 |
| 6 | E - cadherin,CD44 and CD44v6 correlate with tumour differentiation in colorectal cancer显示文摘 | Bendantaf B Elzagheid A Lamlum H | 2005 | Oncol - Rep2005，13，5： | 1 |
| 7 | E-cadherin, CD44S and CD44V6 correlate with tumor differentiation in colorectalcancer显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | OncolRep2005，13，5： | 1 |
| 8 | E-cadherin,CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | Oncol Rep2005，13，5： | 1 |
| 9 | E-cadherin,CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer显示文摘 | Bendardaf R Elzagheid A | 2005 | Oncol Rep2005，13，5： | 1 |
| 10 | E - cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer 显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | Oncol- Rep2005，13，5： | 1 |
| 11 | E-cadherin, CD44S and CD44V6 correlate with tumor differentiation in colorectal cancer显示文摘 | BENDARDAF R ELZAGHEID A LAMLUM H | 2005 | Oncol Rep2005，13，5： | 1 |
| 12 | High cyclooxygenase-2 expression is associated with advanced stages in colorectal cancer 显示文摘 | ELZAGHEID A EMAETIG F ALKIKHIA L | 2013 | Anticancer Res2013，33，8： | 1 |
| 13 | Comparison of CD44 expression in primary tumors and metastases of colorectal cancer显示文摘 | Bendardaf R Algars A Elzagheid A | 2006 | Oncology Reports2006，16，4： | 1 |
| 14 | Comparison of CD44 expression in primary tumours and metastases of colorectal cancer显示文摘 | Bendardaf R A lgars A Elzagheid A | 2006 | Oncol Rep2006，16，4： | 1 |
| 15 | Ecadherin,CD44s and CD44v6 correlate with tumour differentiati on in colorectal cancer显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2009 | Oncol Rep2009，13，5： | 1 |
| 16 | E-cadherin, CD44s and CD44V6 correlate with tumourd ifferentiation in colorectal cancer显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | Oncol Reo2005，13，5： | 1 |
| 17 | Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer显示文摘 | Elzagheid A Korkeila E Bendardaf R | 2008 | Hum Pathol2008，39，12： | 1 |
| 18 | Ecadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer 显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | Oncol Rep2005，13，5： | 1 |
| 19 | Intense cytoplas- mic ezrin immunoreactivity predicts poor survival in colorectal cancer 显示文摘 | Elzagheid A Korkeila E Bendardaf R | 2008 | Hum Pathol2008，39，12： | 1 |
| 20 | E-cadherin,CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer显示文摘 | Bendardaf R Elzagheid A Lamlum H | 2005 | Oncol Rep2005，13，5： | 1 |
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